BritishJournalof Plastic Surgery (1992), 45, 72-75 0 1992 The Trustees of British Association of Plastic Surgeons

Letters to the Editor Reduced thrombogenicity Sir, The thrombogenic nature of the prosthetic materials available thus far limits their use in clinical microsurgery (van der Lei et al., 1989). Actually, this thrombogenicity is just a temporary problem, since after healing of an implanted microarterial prosthesis, a natural potent anti-thrombogenic endothelial surface has formed. Recently, we have found another potent natural antithrombogenic system, i.e. adenosine phosphatase (ADPase) (Bakker et al., 1991). This antithrombogenic system seems to be of particular importance in the glomerular capillary wall, where blood is permanently in contact through the fenestiited endothelial cellsmwith the collagen of the glomerular basement membrane, which is very thrombogenic. With this anti-thrombogenic system in mind, we performed the following pilot study : ADP-ase ‘doated polyurethane (PU) prostheses and noncoated (control) PU prostheses (all microarterial prostheses: I.D. 1.5 mm, length 1.5 cm) were implanted into the carotid artery of the rabbit by means of standard microsurgical techniques (van der Lei et al., 1989) to test whether ADP-ase might function as an adequate anti-thrombogenic coating. The, prostheses were ~ evaluated after 1 hour (n = 2) and 3 weeks (n = 6). After 1 hour, there was extensive, accumulation pf thrombus on the ,innef: surface of the control microarterial PU prostheses, in contrast to the ADP-ase coated prostheses (Fig. 1). At 3 weeks, all control PU microarterial prostheses (n = 6) were’,o&decl, whereas this was the case in only 1 pf the 6 ADP-ase coated microarterial, PU prpstht~es. The patent ADP-ase coat& microarterial PU p$stheses showed already extens

Xeroderma pigmentosum.

BritishJournalof Plastic Surgery (1992), 45, 72-75 0 1992 The Trustees of British Association of Plastic Surgeons Letters to the Editor Reduced throm...
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