Oncotarget, Vol. 7, No. 34
www.impactjournals.com/oncotarget/
Research Paper
White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study Xuan-yu Li1,*, Zhen-chao Tang3,*, Yu Sun1, Jie Tian2, Zhen-yu Liu2, Ying Han1,4 1
Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, 100053, China
2
Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China
3
School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai, Shandong Province, 264209, China
4
Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China
*
These authors contributed equally to this work and should be considered co-first authors
Correspondence to: Ying Han, email: [email protected] Zhen-yu Liu, email: [email protected] Keywords: subjective cognitive decline, diffusion tensor imaging, preclinical Alzheimer’s disease, white matter, tract-based spatial statistics Received: November 09, 2015 Accepted: May 17, 2016 Published: June 15, 2016
ABSTRACT Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer’s disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3±8.0), 35 aMCI (age=69.2±8.6) and 25 AD patients (age=68.3±9.4) and 37 normal controls (NC) (age=65.1±6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p
www.impactjournals.com/oncotarget/
Research Paper
White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study Xuan-yu Li1,*, Zhen-chao Tang3,*, Yu Sun1, Jie Tian2, Zhen-yu Liu2, Ying Han1,4 1
Department of Neurology, XuanWu Hospital of Capital Medical University, Beijing, 100053, China
2
Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China
3
School of Mechanical, Electrical & Information Engineering, Shandong University, Weihai, Shandong Province, 264209, China
4
Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China
*
These authors contributed equally to this work and should be considered co-first authors
Correspondence to: Ying Han, email: [email protected] Zhen-yu Liu, email: [email protected] Keywords: subjective cognitive decline, diffusion tensor imaging, preclinical Alzheimer’s disease, white matter, tract-based spatial statistics Received: November 09, 2015 Accepted: May 17, 2016 Published: June 15, 2016
ABSTRACT Subjective cognitive decline (SCD) may be an at-risk stage of Alzheimer’s disease (AD) occurring prior to amnestic mild cognitive impairment (aMCI). To examine white matter (WM) defects in SCD, diffusion images from 27 SCD (age=65.3±8.0), 35 aMCI (age=69.2±8.6) and 25 AD patients (age=68.3±9.4) and 37 normal controls (NC) (age=65.1±6.8) were compared using Tract-Based Spatial Statistics (TBSS). WM impairments common to the three patient groups were extracted, and fractional anisotropy (FA) values were averaged in each group. As compared to NC subjects, SCD patients displayed widespread WM alterations represented by decreased FA (p
