HHS Public Access Author manuscript Author Manuscript
Int J Cardiol. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: Int J Cardiol. 2016 October 1; 220: 890–894. doi:10.1016/j.ijcard.2016.06.091.
WHAT IS THE ASSOCIATION OF LIPID LEVELS AND INCIDENT STROKE? Stephen P. Glasser, MD*, Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA, [email protected]
Author Manuscript
Aleena Mosher, MS*, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA, [email protected] Maciej Banach, MD*, and Department of Hypertension, Medical University of Lodz, Lodz, Poland, [email protected] George Howard, DrPH* Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA, [email protected]
Abstract Author Manuscript
Background—The association between lipid levels and stroke rates is less than lipid levels and coronary heart disease (CHD) Objective—To assess if there are geographic, racial, and ethnic differences in total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol(HDL-C) and triglyceride levels with incident stroke. Methods—From The REasons for Geographic AndRacial Differences in Stroke (REGARDS) study we evaluated baseline levels of LDL-C, HCL-C, TC, Non-HDL-C (Total - HDL-C) and triglycerides in participants free of prevalent stroke at baseline. Cox Proportional-Hazard models were the main analytical tool used to examine the association between incident stroke and lipids.
Author Manuscript
Corresponding Author: Stephen P. Glasser, MD, 1717 11th Avenue South, MT 638, Birmingham, AL 35294-4410, 205-975-7125, 205-934-7959 (fax), [email protected]. *These authors contributed equally to the manuscript. Aleena Mosher, MS, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA, conducted the statistical analysis. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Authors contributions to this manuscript: Stephen P. Glasser, MD, Aleena Mosher, MS, Maciej Banach, MD, George Howard, DrPH, Dr. Stephen P. Glasser, Dr. Maciej Banach, Dr. George Howard, and Aleena Mosher report no disclosures.
Glasser et al.
Page 2
Author Manuscript
For each adjusted lipid measure (LDL-C, HDL-C, triglycerides, TC, and non-HDL-C) we calculated a series of incremental models. Results—The analysis cohort was 23,867 participants with a mean follow-up time of 7.5 +/− 2.9 years, and 1031 centrally adjudicated strokes (874 ischemic and 77 hemorrhagic strokes). HDL-C baseline level was associated with an overall unadjusted 13% risk reduction (HR 0.87, 95% confidence interval [CI]: 0.81–0.93; p
Int J Cardiol. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: Int J Cardiol. 2016 October 1; 220: 890–894. doi:10.1016/j.ijcard.2016.06.091.
WHAT IS THE ASSOCIATION OF LIPID LEVELS AND INCIDENT STROKE? Stephen P. Glasser, MD*, Department of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA, [email protected]
Author Manuscript
Aleena Mosher, MS*, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA, [email protected] Maciej Banach, MD*, and Department of Hypertension, Medical University of Lodz, Lodz, Poland, [email protected] George Howard, DrPH* Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA, [email protected]
Abstract Author Manuscript
Background—The association between lipid levels and stroke rates is less than lipid levels and coronary heart disease (CHD) Objective—To assess if there are geographic, racial, and ethnic differences in total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol(HDL-C) and triglyceride levels with incident stroke. Methods—From The REasons for Geographic AndRacial Differences in Stroke (REGARDS) study we evaluated baseline levels of LDL-C, HCL-C, TC, Non-HDL-C (Total - HDL-C) and triglycerides in participants free of prevalent stroke at baseline. Cox Proportional-Hazard models were the main analytical tool used to examine the association between incident stroke and lipids.
Author Manuscript
Corresponding Author: Stephen P. Glasser, MD, 1717 11th Avenue South, MT 638, Birmingham, AL 35294-4410, 205-975-7125, 205-934-7959 (fax), [email protected]. *These authors contributed equally to the manuscript. Aleena Mosher, MS, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA, conducted the statistical analysis. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Authors contributions to this manuscript: Stephen P. Glasser, MD, Aleena Mosher, MS, Maciej Banach, MD, George Howard, DrPH, Dr. Stephen P. Glasser, Dr. Maciej Banach, Dr. George Howard, and Aleena Mosher report no disclosures.
Glasser et al.
Page 2
Author Manuscript
For each adjusted lipid measure (LDL-C, HDL-C, triglycerides, TC, and non-HDL-C) we calculated a series of incremental models. Results—The analysis cohort was 23,867 participants with a mean follow-up time of 7.5 +/− 2.9 years, and 1031 centrally adjudicated strokes (874 ischemic and 77 hemorrhagic strokes). HDL-C baseline level was associated with an overall unadjusted 13% risk reduction (HR 0.87, 95% confidence interval [CI]: 0.81–0.93; p
