Curr Allergy Asthma Rep (2014) 14:447 DOI 10.1007/s11882-014-0447-3

OTITIS (DP SKONER, SECTION EDITOR)

What Does Tympanostomy Tube Placement in Children Teach Us About the Association Between Atopic Conditions and Otitis Media? Young J. Juhn & Chung-Il Wi

# Springer Science+Business Media New York 2014

Abstract Otitis media is the most common infection second only to viral upper respiratory infection in the outpatient setting. Tympanostomy tube insertion (TTI) is the most common ambulatory surgical procedure in the USA. While many risk factors for otitis media have been identified, atopic conditions have been underrecognized as risk factors for recurrent and persistent otitis media. Given that asthma and other atopic conditions are the most common chronic conditions during childhood, it is worth examining the association between atopic conditions and risk of otitis media, which can provide insight into how atopic conditions influence the risk of microbial infections. This paper focuses its discussion on otitis media; however, it is important that the association between atopic conditions and risk of otitis media be interpreted in the context of the association of atopic conditions with increased risks of various microbial infections.

CVID HIV HR ICS IPD OR PAR% PBMC PCV7 PPV23 RR Th1 Th2

Common variable immunodeficiency Human immunodeficiency virus Hazard ratios Inhaled corticosteroid Invasive pneumococcal disease Odds ratios Population attributable risk percent Peripheral blood mononuclear cells 7-Valent pneumococcal conjugate vaccine 23-Valent pneumococcal polysaccharide vaccine Risk ratios T helper 1 cells T helper 2 cells

Introduction KEYWORDS Tympanostomy tube . Children . Pediatrics . Otitis media . Adaptive immunity . Allergic rhinitis . Asthma . Atopic dermatitis . Epidemiology . Immune dysfunction . Immune incompetence . Infection . Innate immunity . Phenotype . Risk . Susceptibility ABBREVIATIONS 95 % CI 95 % confidence interval CMI Cell-mediated immunity

This article is part of the Topical Collection on Otitis Y. J. Juhn (*) : C.

What does tympanostomy tube placement in children teach us about the association between atopic conditions and otitis media?

Otitis media is the most common infection second only to viral upper respiratory infection in the outpatient setting. Tympanostomy tube insertion (TTI...
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