RESEARCH ARTICLE
Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants Hidehiko Maruyama1, Naohiro Yonemoto2*, Yumi Kono3, Satoshi Kusuda4, Masanori Fujimura5, Neonatal Research Network of Japan¶ 1 Department of Pediatrics, Kochi Health Sciences Center, Kochi, Kochi, Japan, 2 Department of Neuropsychopharmacology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan, 3 Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan, 4 Department of Neonatology, Maternal and Perinatal Center, Tokyo Women's Medical University, Tokyo, Japan, 5 Department of Neonatology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan ¶ Membership of the Neonatal Research Network of Japan is listed in the Acknowledgments. * [email protected]
OPEN ACCESS Citation: Maruyama H, Yonemoto N, Kono Y, Kusuda S, Fujimura M, Neonatal Research Network of Japan (2015) Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants. PLoS ONE 10(9): e0139014. doi:10.1371/journal.pone.0139014
Abstract Introduction This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs).
Editor: Olivier Baud, Hôpital Robert Debré, FRANCE Received: May 13, 2015 Accepted: September 7, 2015 Published: September 24, 2015 Copyright: © 2015 Maruyama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Due to ethical restrictions, de-identified data are available upon request, pending approval from the ethics committee for each case. Requests may be sent to the Corresponding Author. Funding: This study was supported only by a grant from the Ministry of Health, Labour and Welfare, Japan, in 2013-2014 (H25-IRYO-SHITEI-008) (http:// www.mhlw.go.jp/stf/seisakunitsuite/bunya/hokabunya/ kenkyujigyou/). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Methods Subjects were infants who weighed 501–1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003–2007). Patel’s exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI).
Results In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4– 11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60–3.62) and 1.81 (95%CI, 1.18–2.75), respectively, relative to the reference WGV score of 10. WGV scores 8 did not predict death or NDI.
Conclusions WGV scores
Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants Hidehiko Maruyama1, Naohiro Yonemoto2*, Yumi Kono3, Satoshi Kusuda4, Masanori Fujimura5, Neonatal Research Network of Japan¶ 1 Department of Pediatrics, Kochi Health Sciences Center, Kochi, Kochi, Japan, 2 Department of Neuropsychopharmacology, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan, 3 Department of Pediatrics, Jichi Medical University, Shimotsuke, Tochigi, Japan, 4 Department of Neonatology, Maternal and Perinatal Center, Tokyo Women's Medical University, Tokyo, Japan, 5 Department of Neonatology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan ¶ Membership of the Neonatal Research Network of Japan is listed in the Acknowledgments. * [email protected]
OPEN ACCESS Citation: Maruyama H, Yonemoto N, Kono Y, Kusuda S, Fujimura M, Neonatal Research Network of Japan (2015) Weight Growth Velocity and Neurodevelopmental Outcomes in Extremely Low Birth Weight Infants. PLoS ONE 10(9): e0139014. doi:10.1371/journal.pone.0139014
Abstract Introduction This study aimed to assess whether weight growth velocity (WGV) predicts neurodevelopmental outcomes in extremely low birth weight infants (ELBWIs).
Editor: Olivier Baud, Hôpital Robert Debré, FRANCE Received: May 13, 2015 Accepted: September 7, 2015 Published: September 24, 2015 Copyright: © 2015 Maruyama et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: Due to ethical restrictions, de-identified data are available upon request, pending approval from the ethics committee for each case. Requests may be sent to the Corresponding Author. Funding: This study was supported only by a grant from the Ministry of Health, Labour and Welfare, Japan, in 2013-2014 (H25-IRYO-SHITEI-008) (http:// www.mhlw.go.jp/stf/seisakunitsuite/bunya/hokabunya/ kenkyujigyou/). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Methods Subjects were infants who weighed 501–1000 g at birth and were included in the cohort of the Neonatal Research Network of Japan (2003–2007). Patel’s exponential model (EM) method was used to calculate WGV between birth and discharge. Assessment of predictions of death or neurodevelopmental impairment (NDI) was performed at 3 years of age based on the WGV score, which was categorized by per one increase in WGV. Multivariate logistic regression analysis was used to calculate adjusted odds ratios and their 95% confidence intervals (95%CI).
Results In the 2961 ELBWIs assessed, the median WGV was 10.5 g/kg/day (interquartile, 9.4– 11.9). With the categorical approach, the adjusted odds ratios for death or NDI with WGV scores of 6 and 7 were 2.41 (95%CI, 1.60–3.62) and 1.81 (95%CI, 1.18–2.75), respectively, relative to the reference WGV score of 10. WGV scores 8 did not predict death or NDI.
Conclusions WGV scores
