WCO-IOF-ESCEO MILAN 2015 W ORLD C ON GRE S S ON OS TE OPORO S IS , OS T E OA RTHRITI S AND M U SC UL OS K E LE TAL D I SE A S E S

MARCH 26-29, 2015 | MILAN ITALY MiCo - Fiera Milano Congressi

www.wco-iof-esceo.org

Organized by Sinklar Conference Management B.V.

AN INTERNATIONAL COURSE BY IOF AND ISCD

Take part in a comprehensive training course which provides the latest knowledge on densitometry, diagnosis and management of osteoporosis. u Separate tracks for clinicians and technologists. u Available to clinicians and allied health professionals worldwide. u Participants may opt to take a post-course exam in order to attain an Attestation of Achievement. Find out how to host or participate in a course near you. www.osteoporosis-essentials.org

TABLE OF CONTENTS

OSTEOPOROSIS INTERNATIONAL Vol. 26 (2015) | Supplement 1

About IOF and ESCEO . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Message from the Congress Presidents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . .

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Congress Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . .

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Sponsors and Exhibitors List . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . .

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Congress Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 Venue Map . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases: Final Programme . . . . . . . . . . . . . . . . . . . . . . . . 16 Plenary Lecture Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S29 Oral Communication Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S35 ESCEO Symposia Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S57 IOF Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S63 MTE Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S65 Poster Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S71 Satellite Symposia Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .S381 Non-Sponsored Symposia Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S387 CNS Special Plenary Session Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S397 Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S403

This supplement was not sponsored by outside commercial interests ; it was funded entirely by the society’s own resources

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BROUGHT TO YOU BY

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ABOUT ESCEO The European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) is a non-profit organization, dedicated to a close interaction between clinical scientists dealing with rheumatic disorders, pharmaceutical industry developing new compounds in this field, regulators responsible for the registration of such drugs and health policy makers, to integrate the management of Osteoporosis and Osteoarthritis within the comprehensive perspective of health resources utilization. The objective of ESCEO is to provide practitioners with the latest clinical and economic information, allowing them to organize their daily practice, in an evidence-based medicine perspective, with a cost- conscious perception. www.esceo.org

ABOUT IOF The International Osteoporosis Foundation (IOF) is a non-profit, nongovernmental organization dedicated to the worldwide fight against osteoporosis, the disease known as “the silent epidemic”. IOF’s members – committees of scientific researchers, patient, medical and research societies and industry representatives from around the world – share a common vision of a world without osteoporotic fractures. IOF now represents 230 societies in 97 locations around the world. www.iofbonehealth.org Mission - increase awareness and understanding of osteoporosis. - motivate people to take action to prevent, diagnose and treat osteoporosis. - support national osteoporosis societies in order to maximize their effectiveness.

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IOF

CAPTURE the

FRACTURE

CAPTURE the FRACTURE

®

DOES YOUR FRACTURE LIAISON SERVICE DESERVE GOLD-STAR RECOGNITION? GET MAPPED Submit your service and be part of an internationally recognized FLS network on www.capturethefracture.org

A global campaign facilitating the implementation of Fracture Liaison Services (FLS) for secondary fracture prevention u Providing internationally endorsed standards for best practice u Facilitating change at a national level u Raising awareness among health professionals and the general public

www.capture-the-fracture.org

MESSAGE FROM THE CONGRESS PRESIDENTS Dear Colleagues, It is with great pleasure that we welcome you to Milan and the 2015 IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases. The Congress’ scientific programme has been developed by a team consisting of members of the Committee of Scientific Advisors of the International Osteoporosis Foundation (IOF) and the Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). We would like to thank the Scientific Chairs, Professors Cyrus Cooper and René Rizzoli, for taking the lead in setting up an exciting and comprehensive programme that brings together the world’s best in the bone field, and takes advantage of the synergies and combined expertise of our two organisations. We are all meeting in Milan with a common aim - to gather new knowledge, skills and tools in the prevention and treatment of osteoporosis and osteoarthritis, the two most disabling conditions in elderly people. It is our hope that this Congress will move the field one step forward on all fronts; from new understanding of bone metabolism and pathology, to new strategies and options in prevention, diagnosis and treatment. The core scientific programme consists of 8 plenary lectures by renowned speakers and 50 oral communications selected from the very best of hundreds of submitted abstracts, and 18 oral presentations of selected posters. In addition, participants can choose among 10 different Meet-The-Expert sessions and 16 special sessions and symposia on issues of clinical importance. We also encourage you to attend many of the scheduled poster sessions. 9 industry sponsored satellite symposia and to visit the large commercial exhibition presented by the leading companies in the bone field. We expect that you will also take the opportunity to enjoy the exquisite cultural treasures of Milan, or simply savour “la bella vita” in this wonderful city! Thank you for your participation. We will do our best to ensure that this meeting is a memorable, enriching experience for all.

Jean-Yves Reginster ESCEO President

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John A. Kanis IOF President

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CONGRESS ORGANIZATION Congress Chairmen

Scientific Advisory Board & Abstract Reviewers

Jean-Yves REGINSTER ESCEO President John A. KANIS IOF President

Cyrus COOPER (Chair, IOF Scientific Committee) René RIZZOLI (Chair, ESCEO Scientific Committee)

Scientific Committee Cyrus COOPER Chair, IOF Committee Scientifc Advisors (CSA) René RIZZOLI Chair, ESCEO Scientific Advisory Board (SAB) Jean-Yves REGINSTER ESCEO President John A. KANIS IOF President

Donato AGNUSDEI, Kristina AKESSON, Maurice AUDRAN, Emanuela BAIO DOSSI, Maria Luisa BIANCHI, Jean-Jacques BODY, Mary BOUXSEIN, Maria-Luisa BRANDI, Olivier BRUYERE, Nansa BURLET, Etienne CAVALIER, Paolo CHERUBINO, Claus CHRISTIANSEN, Juliet COMPSTON, Cyrus COOPER, Bernard CORTET, Gaetano CREPALDI, Claudio CRICELLI, Maurizio CUTOLO, Jean-Pierre DEVOGELAER, Andrea GASPARIK, Andrea GENAZZANI, Nicholas HARVEY, Mickaël HILIGSMANN,

Giancarlo ISAIA, John A. KANIS, Jean-Marc KAUFMAN, Andrea LENZI, Paul LIPS, Roman LORENC, George LYRITIS, Stefania MAGGI, Johanne MARTEL-PELLETIER, Marco MATUCCI-CERINIC, Eugene McCLOSKEY, Roberto MESSINA, Ranuccio NUTI, Sergio ORTOLANI, Socrates PAPAPOULOS, Karel PAVELKA, Jean-Pierre PELLETIER, Jean-Yves REGINSTER, Johann RINGE, René RIZZOLI, Christian ROUX, Pavel SZULC, Thierry THOMAS

Local organizing committee Maria-Luisa BRANDI Chair, Local Organizing Committee (LOC) Emanuela BAIO DOSSI, Maria Luisa BIANCHI, Paolo CHERUBINO, Gaetano CREPALDI, Claudio CRICELLI, Maurizio CUTOLO, Andrea GENAZZANI, Giancarlo ISAIA, Andrea LENZI, Stefania MAGGI, Marco MATUCCI-CERINIC, Roberto MESSINA, Ranuccio NUTI, Sergio ORTOLANI

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CONGRESS ORGANIZATION Congress Organizer SINKLAR Conference Management B.V. Email: [email protected] Hogehilweg 7K 1101CA Amsterdam Zuidoost Netherlands

Sponsors and Exhibitors List DIAMOND SPONSORS

Secretariat Yolande Piette Communication Email: [email protected] Bd G. Kleyer, 108 B-4000 Liège, Belgium Tel: +32 (0)4 254 12 25 Fax: +32 (0)4 254 12 90 Website: www.piettecommunication.com

PLATINUM SPONSOR

Registration and Hotel Booking AIM Group INTERNATIONAL Registration: [email protected] Tel: +39 06 33 053 308 Fax: +39 06 33 053 229 Hotel Booking: [email protected] Tel: +39 02 56 60 11 Fax: +39 02 56 60 90 43

GOLD SPONSOR

SILVER SPONSOR

Abstract Submission Yolande Piette Communication Email: [email protected] Bd G. Kleyer, 108 B-4000 Liège, Belgium Tel: +32 (0)4 254 12 25

Sponsorship Opportunities / Exhibition Yolande Piette Communication Email: [email protected] Bd G. Kleyer, 108 B-4000 Liège, Belgium Tel: +32 (0)4 254 12 25 Fax: +32 (0)4 254 12 90

Congress website www.wco-iof-esceo.org

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GENERAL SPONSORS AgNovos Healthcare Alexion BioPharma Services Inc. BoneIndex Danone Echolight GE Healthcare Medical Systems Hologic Lilly Medi Medimaps Group Novamedical Oscare Medical Takeda Wisepress

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CONGRESS INFORMATION Congress Venue (27-29 March) MiCo – Fiera Milano Congressi Via Gattamelata 5 Entrance Gate 14 20149 Milan, Italy Tel : +39 02 4997 6275 Fax : +39 02 4801 0265 Website: www.micomilano.it

Congress Venue on Thursday 26 March 2015 Fondazione delle Stelline Corso Magenta, 61, 20123 Milano, Italy Tel: +39 02 4546 2411 Website: www.stelline.it

BY TRAIN

>Central Station – Garibaldi Station Take the Metro Green Line 2 (Abbiategrasso direction) and get off at “Cadorna”. There take the Metro Red Line 1 (Rho Fiera Milano direction). for the “piazzale Carlo Magno / via Gattamelata” entrance: get off at the “Cadorna” stop, exit the subway and go to the railroad station above : take the first train departing and get off at the “Domodossola” stop – just 600m away from the Congress Centre. >Stazione Cadorna Take the Metro Red Line 1 (Rho Fiera Milano direction). For the “piazzale Carlo Magno / via Gattamelata” entrance: get off at the “Cadorna” stop, exit the subway and go to the railroad station above : take the first train departing and get off at the “Domodossola” stop – just 600m away from the Congress Centre.

BY CAR

Operating Dates and Hours Congress Opening Hours: Location : Fondazione delle Stelline 15.30-21.05 Thursday, March 26, 2015 Location : MiCo – Fiera Milano Congressi Friday March 27, 2015 07.30-18.30 07.30-18.30 Saturday March 28, 2015 07.30-12.10 Sunday March 29, 2015 Registration Desks Opening Hours: Location : MiCo – Fiera Milano Congressi 07.30-18.30 Friday March 27, 2015 07.30-18.30 Saturday March 28, 2015 07.30-12.10 Sunday March 29, 2015 Congress Exhibition Hours: Location : MiCo – Fiera Milano Congressi 08.00-18.30 Friday March 27, 2015 08.00-18.30 Saturday March 28, 2015 08.00-12.10 Sunday March 29, 2015

Poster Viewing Poster Session I (P101-P400) Friday March 27, 2015

14.00-15.00

Poster Session II (P401-P800) Saturday March 28, 2015

14:00-15:00

Oral Presentation of Selected Posters 14.00-15.00 Friday March 27, 2015 14.00-15.00 Saturday March 28, 2015

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How to Reach the Congress Center?

From any of the ring roads circling Milan follows the signs to Fieramilanocity, or to any of the large Park & Ride car parks located close to these Metro stops: Cascina Gobba (1800 cars). Green Line San Donato (1800 cars). Yellow Line Famagosta (3000 cars). Green Line Bisceglie (1900 cars). Red Line Lampugnano (2000 cars). Red Line

PUBLIC TRANSPORT

>Buses & Trams For the “piazzale Carlo Magno / via Gattamelata” entrance: Bus no. 78 – get off at Colleoni/Gattamelata Tram no. 27 - get off at Piazza 6 Febbraio >Metro Red Line 1: for the “piazzale Carlo Magno / via Gattamelata” entrance: get off at the “Cadorna” stop, exit the subway and go to the railroad station above : take the first train departing and get off at the “Domodossola” stop – just 600m away from the Congress Centre. Green Line 2: get off at “Cadorna”. For the “piazzale Carlo Magno / via Gattamelata” entrance: exit the subway and go to the railroad station above: take the first train departing and get off at the “Domodossola” stop – just 600m away from the Congress Centre. Yellow Line 3: Get off at “Duomo”, switch to the Red Line 1 (RHO Fiera Milano direction). For the “piazzale Carlo Magno / via Gattamelata” entrance: get off at the “Cadorna” stop, exit the subway and go to the railroad station above : take the first train departing and get off at the “Domodossola” stop – just 600m away from the Congress Centre. SPECIAL SERVICES - Navetta circolare On request, you can use a shuttle bus that links the Metro Red Line 1, “Amendola” stop (Porta Metropolitana) with the entrance to the Congress Centre.

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CONGRESS INFORMATION Accreditation

Lunches, coffee and refreshments

European Accreditation The WCO-IOF-ESCEO 2015 Congress was granted 15 European CME credits (ECMEC) by the European Accreditation Council for Continuing Medical Education (EACCME - www.eaccme.eu)

In order to comply with international compliance rules, no official lunches or coffee breaks will be provided. Coffee, beverages and snacks can be purchased from the cafeteria located in the exhibition area and opened during Congress hours.

Belgian Accreditation (in process)

Badges For registered participants, personalized badges will be requested for entry to all scientific programmes and to access the exhibition and posters areas. Blank badges are prohibited. Lost badges : 65 euros fee/badge

Certificate of Attendance A certificate of attendance may be printed at the self-printing stations available in the Registration Area on Saturday March 28, 2015. This system will issue your certificate with date from the barcode printed on your badge. Please ensure that you have your badge with you.

Cloakroom A cloackroom service for clothing and reasonably sized items is available during the opening hours of the Congress. It is located next to the registration desk. Items of value should not be left in the cloakroom. Please make sure to collect all belongings at the end of each day.

Hotel Information Desk The Hotel Desk is located in the Registration Area during Registration opening hours.

Internet Access Courtesy of ESCEO A free Wireless internet connexion is available in the Congress Center. An Internet Corner with computers will be also available to all delegates at level +1 during the Congress Exhibition Hours.

Congress Bags

Media The WCO-IOF-ESCEO 2015 Congress will not provide any Media Centre, however Media representatives are free to use the Internet Corner available durng Congress hours.

Notebook and Pen Courtesy of Abiogen A notebook and a pen are included in the congress bag.

Pocket Programme A Pocket programme is included with your badge.

Tourist Information www.visitamilano.it

General Emergency Number European Telephone Number : 112

Welcome Cocktail Courtesy of Meda AB All WCO-IOF-ESCEO 2015 participants are invited to the Welcome Cocktail on Thursday March 26th, 2015 Venue : Fondazione delle Stelline Corso Magenta, 61, 20123 Milano, Italy

Future Meeting 2016 – WORLD CONGRESS ON OSTEOPOROSIS, OSTEOARTHRITIS AND MUSCULOSKELETAL DISEASES WCO-IOF-ESCEO 2016 Malaga – Spain April 14-17, 2016

Courtesy of Abiogen

Language

Abstract Usb Key

English will be the official language of the Congress. No translation is provided.

Courtesy of MSD

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CONGRESS VENUE - FLOOR PLAN - LEVEL +1

MEETING ROOM (Blue Hall 1)

MEETING ROOM (Yellow Hall 1)

MEETING ROOM (Yellow Hall 2)

AUDITORIUM B (Red Hall)

CLOAKROOM

MEETING ROOM (Blue Hall 2) MEETING ROOM (Yellow Hall 3)

B A

22 23

ACCESS LEVEL +2

AUDITORIUM A

25

21

15 14

E

BAR

8

10

C

1

ENTRANCE EXIT

18 17 16

6 5

11

13

REGISTRATION

20

19

9 EXHIBITION AREA D

4

3

2

REGISTRATION

7

24

BAGS DELIVERY

POSTER AREA

A B C D E

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CONGRESS VENUE - FLOOR PLAN - LEVEL -1

MEETING ROOM (Green Room 2)

MEETING ROOM (Green Room 3)

MEETING ROOM 6

CONGRESS VENUE - FLOOR PLAN - LEVEL +2 ACCESS LEVEL +1

MEETING ROOM (White Room 1)

AUDITORIUM A (Silver Hall)

MEETING ROOM (White Room 2)

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3 RD WORLD CONGRESS on Controversies, Debates & Consensus

BMJD

in

Bone, Muscle & Joint Diseases

Montreal, Canada April 23-26, 2015

Under the auspices of the IOF and ESCEO

More opportunities to learn • Interact with experts from all areas of rheumatology in one location • Acquire updates at one congress that would otherwise require attendance at many congresses • Consensus on controversial issues in the field

More opportunities to connect

• Meet with colleagues and experts in various sub-disciplines

More opportunities to share

• Numerous presentations by bone, muscle and joint disease experts from all over the world, via lectures, oral and poster presentations • Young scientists competition for best abstract presenters

Join experts from all fields of Osteoporosis, Osteoarthritis, Rheumatoid Arthritis & Muscle Diseases

www.congressmed.com/bmjd

Powered by MCI Group

c/o MCI Geneva | 75 Rue de Lyon | C.P. 502 CH-1211 | Geneva 13 | Switzerland Tel. +41 22 33 99 985 | Fax. +972 3 725 6266 | www.facebook.com/BMJDCongress

www.congressmed.com/bmjd [email protected]

FINAL PROGRAMME

THURSDAY MARCH 26, 2015 15.30-17.30 Fondazione Stelline Italian Session jointly organized by F.I.R.M.O. and E.S.C.E.O. Chairpersons: Maria‑Luisa Brandi, Bruno Rusticali - Introduction - Maria‑Luisa Brandi - AGENAS Guidelines on Osteoporosis: Methodology and Goals - Bruno Rusticali - The Reimbursement Policy for Osteoporosis Drugs in Italy - Ranuccio Nuti - Osteoporosis: The Challenges for the General Practitioner - Claudio Cricelli - Osteoarticular Disorders: The Multidimentional Approach of the “Società Italiana di Ortopedia e Traumatologia” (SIOT) - Umberto Tarantino - The Contribution of the “Società Italiana di Reumatologia”(SIR) in the Fight against Osteoarticular Disorders - Marco Matucci Cerinic - The Projects of the “Società Italiana dell’Osteoporosi e del Metabolismo Minerale e delle Malattie dello Scheletro” (SIOMMMS) in Osteoporosis - Giancarlo Isaia - Definition and Evaluation of Sarcopenia: The Italian Vision of the Geriatrician Stefania Maggi - The Integrated Approach to Prevent refracture: The Fracture Unit Project of the OrtoMed Scientific Society - Luisella Cianferotti 17.30-18.30 Best clinical papers published in 2014 René Rizzoli

Fondazione Stelline

18.30-20.05 WCO-IOF-ESCEO - OPENING CEREMONY Chairpersons: John A. Kanis, Jean‑Yves Reginster

Fondazione Stelline

18.30-18.45 Population ageing and health: the importance of policies to tackle musculoskeletal diseases Islene Araujo de Carvalho (World Health Organization – Geneva)

Fondazione Stelline

18.45-18.50 Opening of the meeting John A. Kanis

Fondazione Stelline

18.50-19.50 IOF-ESCEO-SERVIER HONORARY LECTURE - Historical genetics of wine grapes - José Vouillamoz

Fondazione Stelline

19.50-20.00 Presentation of the ESCEO-IOF Servier Pierre D. Delmas Prize John A. Kanis

Fondazione Stelline

20.00-20.05 Presentation of the ESCEO-IOF Herbert Fleisch Medal Bess Dawson‑Hughes

Fondazione Stelline

20.05-21.05 INDUSTRY-SPONSORED WELCOME COCKTAIL

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Fondazione Stelline

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FINAL PROGRAMME

FRIDAY MARCH 27, 2015 08.00-09.00 NON-SPONSORED SYMPOSIUM

Application of Shape and Appearance Models in Blue 1 Osteoporosis and Osteoarthritis Chairperson: John Sheperd - Introduction to Statistical Appearance Modeling for Bone Applications - Tim Cootes - 3D to 2D and back again: registration and modeling of 3D bone from 2D images for osteoporosis applications - Kenneth Poole - 3D Shape Characteristics of Arthritic Bone - Tuhina Neogi - 3D femur shape and appearance for fracture prediction - Is it ready for clinical applications? - Oleg Museyko Targeting Osteosarcopenia: a practical approach for the Blue 2 prevention of falls and osteoporotic fractures Chairperson: Neil Binkley - Introduction - Neil Binkley - Pathophysiology of osteosarcopenia: Common mechanisms and pathways - Gustavo Duque - How to diagnose osteosarcopenia? - Bjoern Buering - Therapeutic interventions for osteosarcopenia - Christina Alonso Yellow 1 The personal and societal burden of Osteoarthritis: observations from EPOSA Chairperson: Elaine M. Dennison - Introduction - Elaine M. Dennison - Osteoarthritis and comorbidities as determinants of disability in older populations - Stefania Maggi - Physical performance in later life and its relationship with Osteoarthritis - Mark H. Edwards - Frailty syndrome prevalence and slow walk speed in Osteoarthritis Angel Otero - The neighbourhood environment and use of neighbourhood resources in older people with and without Osteoarthritis - Erik Timmermans NOF WORKSHOP Yellow 2 Calcium Supplementation: Does Protecting Against Fracture Risk Increase the Risk of Cardio-vascular Diseases? Chairperson: Taylor C. Wallace - Calcium Supplementation and the Risk of Cardiovascular Events Andrea Singer - The Role of Calcium Supplementation in Coronary Artery Disease: What is the Evidence? - Stephen Kopecky 08.30-09.00 SPECIAL EDUCATIONAL LECTURE - Unexpected non bone effects of vitamin D - Maurizio Cutolo 09.00-10.20 SCIENTIFIC SESSION I Chairpersons: John A. Kanis, Jean‑Yves Reginster

White 1

Auditorium A

09.00-09.30 Auditorium A Plenary Lecture 1 - Osteoporosis and Sarcopenia: two disorders or one? - Roger Fielding 09.30-10.20 Oral communications selected from abstracts

Auditorium A

09.30-09.40 Auditorium A OC1 ODANACATIB ANTIFRACTURE EFFICACY AND SAFETY IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS: RESULTS FROM THE PHASE III LONG-TERM ODANACATIB FRACTURE TRIAL (LOFT) Presenting author: M. R. McClung Authors: B. L. Langdahl, S. Papapoulos, K. G. Saag, S. Adami, H. G. Bone, T. De Villiers, D. P. Kiel, A. Kung, P. Kumar KM, S. K. Lim, X. Ling, K. Lippuner, C. Mautalen, T. Nakamura, J.‑Y. Reginster, I. R. Reid, J. A. Rodriguez Portales, C. Roux, J. Walliser, N. B. Watts, J. R. Zanchetta, C. A. F. Zerbini, A. Rybak‑Feiglin, D. Cohn, C. A. DaSilva, R. Massaad, A. C. Santora, B. B. Scott, K. D. Kaufman, N. Verbruggen, A. Leung, A. Lombardi

ABSTRACT BOOK

09.40-09.50 Auditorium A OC2 THE BMD RESPONSE TO BLOSOZUMAB IS INDEPENDENT OF INITIAL AGE, BODY MASS INDEX, AND BMD IN POSTMENOPAUSAL WOMEN WITH LOW BMD: RESULTS OF A PHASE 2 RANDOMIZED CLINICAL TRIAL Presenting author: B. Mitlak Authors: A. Chiang, F. Marin, J. Krege, C. T. Benson 09.50-10.00 Auditorium A OC3 RESULTS OF 2 YEARS OF ROMOSOZUMAB TREATMENT FOLLOWED BY 1 YEAR OF DENOSUMAB OR PLACEBO IN POSTMENOPAUSAL WOMEN WITH LOW BONE MINERAL DENSITY Presenting author: M. R. McClung Authors: A. Chines, J. P. Brown , A. Diez‑Perez, H. Resch, J. Caminis, M. A. Bolognese, S. Goemaere, H. G. Bone, J. R. Zanchetta, J. Maddox, O. Rosen, S. Bray, A. Grauer 10.00-10.10 Auditorium A OC4 DENOSUMAB TREATMENT IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS FOR UP TO 9 YEARS: RESULTS THROUGH YEAR 6 OF THE FREEDOM EXTENSION Presenting author: S. Papapoulos Authors: C. Roux, H. G. Bone, P. Dakin, E. Czerwinski, D. Frey, D. L. Kendler, E. M. Lewiecki, J. Malouf, D. Mellström, J.‑Y. Reginster, H. Resch, N. S. Daizadeh, A. Wang, M. Gavin, R. B. Wagman, M. L. Brandi 10.10-10.20 Auditorium A OC5 THE POSITION OF STRONTIUM RANELATE IN TODAY'S MANAGEMENT OF OSTEOPOROSIS Presenting author: J.‑Y. Reginster Authors: M. L. Brandi, J. Cannata Andia, C. Cooper, B. Cortet, J. M. Feron, H. K. Genant, S. Palacios, J. D. Ringe, R. Rizzoli 10.20-11.50 SCIENTIFIC SESSION II Chairpersons: Cyrus Cooper, Jean‑Pierre Pelletier 10.20-10.50 Plenary Lecture 2 - Management of Osteoporosis in Renal Failure Marie‑Hélène Lafage‑Proust 10.50-11.00 Presentation of the ESCEO-MSD Fellowships Bess Dawson‑Hughes 11.00-11.50 Oral communications selected from abstracts

Auditorium A

Auditorium A

Auditorium A

Auditorium A

11.00-11.10 Auditorium A OC6 TRACKING OF 25-HYDROXYVITAMIN D STATUS DURING PREGNANCY Presenting author: R. J. Moon Authors: S. R. Crozier, E. M. Dennison, S. M. Robinson, H. M. Inskip, K. M. Godfrey, C. Cooper, N. C. Harvey 11.10-11.20 Auditorium A OC7 EFFECTIVENESS OF MATERNAL VITAMIN D SUPPLEMENTATION: A MULTICENTRE RANDOMISED, DOUBLE-BLIND, PLACEBO CONTROLLED TRIAL (MAVIDOS) Presenting author: C. Cooper Authors: N. C. Harvey, M. K. Javaid, N. J. Bishop, S. Kennedy, A. T. Papageorghiou, R. Fraser, S. V. Gandhi, S. D'angelo, S. R. Crozier, R. J. Moon, N. K. Arden, E. M. Dennison, K. M. Godfrey, H. M. Inskip, I. Schoenmakers, A. Prentice, Z. Mughal, R. Eastell , D. M. Reid, The Mavidos Study Group

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FRIDAY MARCH 27, 2015 11.20-11.30 OC8 Auditorium A COST EFFECTIVENESS EVALUATION OF FRACTURE LIAISON SERVICES FOR THE MANAGEMENT OF OSTEOPOROSIS IN SWEDEN Presenting author: E. Jonsson Authors: O. Ström, F. Borgström 11.30-11.40 Auditorium A OC9 CLINICAL EFFECTIVENESS OF ORTHOGERIATRIC AND FRACTURE LIAISON SERVICE MODELS OF CARE FOR HIP FRACTURE PATIENTS: CONTROLLED LONGITUDINAL STUDY Presenting author: S. Hawley Authors: M. K. Javaid, D. Prieto‑Alhambra, N. K. Arden, J. Lippett, S. Sheard, C. Cooper, A. Judge 11.40-11.50 Auditorium A OC10 META-ANALYSIS OF OBSERVATIONAL STUDIES ON THE EFFECT OF INCRETIN TREATMENT ON FRACTURE RISK Presenting author: J. H. M. Driessen Authors: F. De Vries, P. Vestergaard, H. Van Onzenoort, J. Van Den Bergh, R. Henry, N. C. Harvey 12.15-13.45 Auditorium A INDUSTRY-SPONSORED LUNCH SYMPOSIUM ESCEO Algorithm for Osteoarthritis: from treatment guidelines to real life Chairpersons: Maurizio Cutolo, Jean‑Yves Reginster - Biological and clinical effects of intra-articular hyaluronic acid: metaanalyses and real-life patient studies - Thierry Conrozier - Prevention and treatment of knee osteoarthritis with glucosamine sulfate: from clinical studies to real life. - Lucio C. Rovati - How can we help implementing ESCEO algorithm in real life Jean‑Yves Reginster 12.15-13.45 Auditorium B INDUSTRY-SPONSORED LUNCH SYMPOSIUM Calcium and vitamin D – Fact and fiction Chairperson: John A. Kanis - Welcome and introduction - John A. Kanis - Efficacy of calcium and vitamin D supplementation: Where are we now? - Cyrus Cooper - Calcium and vitamin D supplementation: Update on safety profile René Rizzoli - Bone protective therapies with and without calcium and vitamin D – Does it matter? - Bess Dawson‑Hughes - Meeting summary and close - John A. Kanis 14.00-15.03 Oral presentation of selected posters Chairperson: Johanne Martel‑Pelletier

Podium

14.00-14.07 Podium P197 TEN-YEAR RISKS OF FIRST OSTEOPOROTIC FRACTURES IN CHINESE WOMEN AND MEN Presenting author: L. Si Authors: T. M. Winzenberg, A. J. Palmer 14.07-14.14 Podium P760 PERSISTENCE LONG-TERM OF ALENDRONATE THERAPY ON OSTEOPOROTIC POPULATION IN TUSCANY REGION Presenting author: G. Marcucci Authors: L. Cianferotti, G. Gronchi, S. Parri, M. L. Brandi

ABSTRACT BOOK

14.14-14.21 Podium P268 PERCENTAGE OF WOMEN ACHIEVING NON-OSTEOPOROTIC BMD T-SCORES AT THE LUMBAR SPINE (LS) AND TOTAL HIP (TH) DURING UP TO 8 YEARS OF DENOSUMAB (DMAB) TREATMENT Presenting author: S. Ferrari Authors: C. Libanati, C. J. F. Lin, S. Adami, J. P. Brown , F. Cosman, E. Czerwinski, L. H. De Gregório, J. Malouf, J.‑Y. Reginster, N. S. Daizadeh, A. Wang, R. B. Wagman, E. M. Lewiecki, S. Cummings 14.21-14.28 Podium P274 FRAX PREDICTS INCIDENT FALLS IN ELDERLY WOMEN: FINDINGS FROM AUSTRALIA Presenting author: H. Johansson Authors: N. C. Harvey, A. Odén, E. V. McCloskey, J. A. Kanis, G. Nicholson, K. M. Sanders 14.28-14.35 Podium P638 GREATER ACCESS TO FAST FOOD OUTLETS IS ASSOCIATED WITH POORER BONE HEALTH IN YOUNG CHILDREN Presenting author: C. Vogel Authors: C. Parsons, K. M. Godfrey, S. M. Robinson, N. C. Harvey, H. M. Inskip, C. Cooper, J. Baird 14.35-14.42 Podium P485 PROLONGED HYPOVITAMINOSIS D IN ELDERLY WOMEN IS ASSOCIATED WITH LONG AND SHORT TERM MORTALITY: RESULTS FROM THE OPRA COHORT Presenting author: D. Buchebner Authors: F. E. Mcguigan, P. Gerdhem, M. Ridderstråle, K. Akesson 14.42-14.49 Podium P753 COST-EFFECTIVENESS OF DAIRY PRODUCTS SUPPLEMENTED WITH VITAMIN D IN THE PREVENTION OF OSTEOPOROTIC FRACTURES Presenting author: O. Ethgen Authors: M. Hiligsmann, O. Bruyère, J.‑Y. Reginster 14.49-14.56 Podium P279 QOL IMPROVEMENT OF OSTEOPOROTIC PATIENTS TREATED WITH ALENDRONATE ALONE OR ALENDRONATE PLUS ALFACALCIDOL THERAPY: RESULTS OF THE JAPANESE OSTEOPOROSIS INTERVENTION TRIAL (JOINT) 02 Presenting author: H. Orimo Authors: H. Ohta, M. Shiraki, T. Nakamura 14.56-15.03 Podium P763 SELF-RATED HEALTH PREDICTS HIP FRACTURES INDEPENDENT OF FRAX Presenting author: H. Lundin 14.00-15.00 Poster Viewing Session I (P101-P400)

Poster area

Auditorium B EDUCATIONAL LECTURE 1 - How to apply for a job in a pharmaceutical company - Lucio C. Rovati

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FINAL PROGRAMME

FRIDAY MARCH 27, 2015 14.00-15.00 ESCEO SYMPOSIA

15.40-16.40 Oral communications selected from abstracts

Revision of the guidelines for the registration of drugs Blue 1 to be used in the treatment of Osteoarthritis Chairpersons: Andrea Laslop, Susanne Reiter‑Niesert - Welcome and introduction - Andrea Laslop - Current regulatory requirements for registration of drugs to be used in osteoarthritis in Europe and need for clarification - Jean‑Yves Reginster - Suggested clarification by the ESCEO working group - Francis Berenbaum - Discussion - Leader: Stefania Maggi - Conclusions and wrap-up - Andrea Laslop Panel: Francis Berenbaum, Jaime Branco, Maria‑Luisa Brandi, Olivier Bruyère, Cyrus Cooper, Jean‑Pierre Devogelaer, Gabriel Herrero‑Beaumont, John A. Kanis, Andrea Laslop, Stefania Maggi, Jean‑Yves Reginster, Susanne Reiter‑Niesert, René Rizzoli

15.40-15.50 Auditorium A OC11 WANING LONG-TERM PREDICTIVE VALUE OF FALLS HISTORY FOR INCIDENT FRACTURE: MROS SWEDEN Presenting author: H. Johansson Authors: N. C. Harvey, A. Odén, M. K. Karlsson, B. Rosengren, O. Ljunggren, C. Cooper, E. V. McCloskey, J. A. Kanis, C. Ohlsson, D. Mellström

Blue 2 Improving Osteoporosis Care with Trabecular Bone Structure (TBS) Chairpersons: David L. Kendler, Claus C. Glüer - Welcome and introduction - Claus C. Glüer - TBS in fracture risk assessment - Nicholas Harvey - Other potential applications of TBS - Neil Binkley - Discussion leaders - Claus Glüer - John A. Kanis - Conclusions - John A. Kanis Panel: Neil Binkley, Maria‑Luisa Brandi, Bruno Muzzi Camargos, Cyrus Cooper, Claus C. Glüer, John A. Kanis, David L. Kendler, Olivier Lamy, Andrea Laslop, Jean‑Yves Reginster, René Rizzoli 14.00-15.00 MEET-THE-EXPERT SESSIONS

Sequential/combined therapies in Osteoporosis Serge Ferrari

Yellow 3

Management of pain in Osteoporosis Maria‑Luisa Brandi

Yellow 2

Exercise, nutrition, bone and muscles Bess Dawson‑Hughes

Yellow 1

Epidemiology and management of post-menopausal Osteoporosis in Latin America Patricia Clark

White 1

G enetic markers for the prediction of fragility fractures White 2 Fernando Rivadeneira Role of nutriceuticals in the management of Osteoarthritis Gabriel Herrero‑Beaumont

Green Room 3

Imaging of osteoarthritis in daily practice Philip Conaghan

Green Room 2

15.00-16.40 SCIENTIFIC SESSION III Chairpersons: René Rizzoli, Olivier Bruyère

Auditorium A

15.00-15.30 Auditorium A Plenary Lecture 3 - Bone anabolic therapies for Osteoporosis - Socrates Papapoulos 15.30-15.40 Presentation of the IOF President’s Awards John A. Kanis

ABSTRACT BOOK

Auditorium A

Auditorium A

15.50-16.00 Auditorium A OC12 PAINFUL KNEE BUT NOT HAND OSTEOARTHRITIS PREDICTS EXCESS MORTALITY IN A COMMUNITY-BASED COHORT OF MIDDLE-AGED WOMEN WITH 23 YEARS OF FOLLOW-UP Presenting author: S. Kluzek Authors: M. T. Sanchez‑Santos, K. M. Leyland, A. Judge, C. Cooper, J. Newton, N. K. Arden, T. D. Spector, D. Hart 16.00-16.10 Auditorium A OC13 DIACEREIN REDUCES ANTAGONISTS OF WNT ENABLING THIS SYSTEM'S ACTIVITY IN HUMAN OSTEOARTHRITIC SUBCHONDRAL BONE OSTEOBLASTS Presenting author: J. Martel‑Pelletier Authors: F. Mineau, D. Hum, J.‑P. Pelletier 16.10-16.20 Auditorium A OC14 ASSESSMENT AND DETERMINANTS OF AESTHETIC DISCOMFORT IN HAND OSTEOARTHRITIS: THE LIÈGE HAND OSTEOARTHRITIS COHORT (LIHOC) Presenting author: A. Neuprez Authors: O. Bruyère, N. Dardenne, S. Distèche, E. Maheu, N. Burlet, J.‑Y. Reginster 16.20-16.30 Auditorium A OC15 PREDICTORS OF POST-OPERATIVE MORTALITY FOLLOWING TOTAL HIP ARTHROPLASTY SURGERY: A POPULATION-BASED COHORT STUDY Presenting author: D. Prieto‑Alhambra Authors: C. Tebé, F. Pallisó, A. Judge, N. K. Arden, C. Cooper, M. Espallargues 16.30-16.40 Auditorium A OC16 BIOMARKERS OF OSTEOCHONDRAL BONE FORMATION ARE INCREASED IN PSORIASIS ARTHRITIS AND SPONDYLOARTHRITIS Presenting author: A. C. Bay‑Jensen Authors: N. S. Gudmann, H. L. Munk, A. F. Christiansen, L. Ejstrup, G. L. Sorensen, A. G. Loft, C. Christiansen, A. S. Siebuhr, P. Junker, M. K. Karsdal 17.00-18.30 Auditorium B INDUSTRY-SPONSORED SATELLITE SYMPOSIUM Evolving Strategies for Management of Osteoporosis Chairperson: Silvano Adami - Opening Remarks - Silvano Adami - The Role of Cathepsin K in Bone Homeostasis - Ego Seeman - Odanacatib Antifracture Efficacy in Postmenopausal Women; Results From the Phase 3 Long-term Odanacatib Fracture Trial (LOFT) Michael R. McClung - Safety and Tolerability of Odanacatib in Post-Menopausal Women; Interim Results From the Phase 3 Long-term Odanacatib Fracture Trial (LOFT) - Socrates Papapoulos - Closing - Panel Question and Answer - Silvano Adami

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FINAL PROGRAMME

FRIDAY MARCH 27, 2015 17.00-18.30 INDUSTRY-SPONSORED SATELLITE SYMPOSIUM Blue 1 Management of severe osteoporosis: personnalized medicine in practice Chairpersons: Maria‑Luisa Brandi, Jean‑Yves Reginster - Introduction - Maria‑Luisa Brandi - Why is severe Osteoporosis still an unmet medical need 40 years after the discovery of the first drugs? - Maria‑Luisa Brandi - Management of patients contra-indicated or not tolerant to anti-resorptive treatments - René Rizzoli - New indication and safety of strontium ranelate: a comprehensive review Cyrus Cooper - Conclusion - Jean‑Yves Reginster 18.45-19.45 Cocktail offered by IOF and ESCEO to all recipients of prizes, awards, fellowships and scholarships - by invitation only

ABSTRACT BOOK

20

FINAL PROGRAMME

SATURDAY MARCH 28, 2015 08.00-09.00 IOF WORKSHOPS

Bone and Diabetes: Diabetes and Skeletal challenges Chairpersons: Massimo Massi Benedetti, Cyrus Cooper - Epidemiology of Diabetes and Osteoporosis - Bo Abrahamsen - Pathophysiology of Diabetoporosis - Serge Ferrari - New Diabetes Treatments and Bone - Nicola Napoli

Blue 2

IMS-IOF Joint Session: MHT: Menopausal Hormone Yellow 1 Therapy revisited Chairpersons: René Rizzoli, Bess Dawson‑Hughes - Menopause: consequences and overall management - John C. Stevenson - MHT: risks and benefits from the IMS perspective - Tobie De Villiers - SERM/HRT combinations - Peyman Hadji NON-SPONSORED SYMPOSIUM Blue 1 Hands-on on DXA acquisition and analysis: artifactual pitfalls and possible escapes Chairpersons: Bruno Muzzi Camargos, Ben‑Hur Albergaria - Dual X-Ray Absorptiometry Basic Principles - Bruno Muzzi Camargos - Clinical Cases. Lumbar Spine, Femur - Bruno Muzzi Camargos - Monitoring DXA - Bruno Muzzi Camargos Yellow 2 The nutritional approach to weight management and musculoskeletal health Chairpersons: René Rizzoli, Jean‑Jacques Body - The benefits of yogurt to manage weight and metabolic diseases Arne Astrup - Dairies and sustainable musculoskeletal health - René Rizzoli 09.00-10.20 SCIENTIFIC SESSION IV Chairpersons: Maria‑Luisa Brandi, Stefania Maggi

Auditorium A

09.00-09.30 Auditorium A Plenary Lecture 4 - Can we alter the natural history of Osteoarthritis? - Marc Hochberg 09.30-09.40 Presentation of the IOF Medal of Achievement Cyrus Cooper 09.40-10.20 Oral communications selected from abstracts

Auditorium A

Auditorium A

09.40-09.50 Auditorium A OC17 BONE MICROARCHITECTURE ASSESSED BY HR-PQCT PREDICTS INCIDENT FRAGILITY FRACTURE IN POSTMENOPAUSAL WOMEN: THE OFELY STUDY Presenting author: E. Sornay‑Rendu Authors: S. Boutroy, F. Duboeuf, R. D. Chapurlat 09.50-10.00 Auditorium A OC18 A META-ANALYSIS OF TRABECULAR BONE SCORE IN FRACTURE RISK PREDICTION AND ITS INTERACTION WITH FRAX Presenting author: J. A. Kanis Authors: A. Odén, N. C. Harvey, W. D. Leslie, D. Hans, H. Johansson, R. Barkmann, S. Boutroy, J. P. Brown , R. D. Chapurlat, P. Elders, Y. Fujita, C. C. Glüer, D. Goltzman, M. Iki, M. K. Karlsson, A. Kindmark, N. Kurumatani, A. Kwok, J. Leung, K. Lippuner, O. Ljunggren, M. Lorentzon, D. Mellström, T. Merlijn, L. Oei, C. Ohlsson, J. A. Pasco, F. Rivadeneira, B. Rosengren, E. Sornay‑Rendu, P. Szulc, J. Tamaki, E. V. McCloskey

10.10-10.20 Auditorium A OC20 SENSITIVITY AND SPECIFICITY OF RADIOGRAPHIC CHARACTERISTICS OF ATYPICAL FEMORAL FRACTURES Presenting author: J. Q. Chantra Authors: A. L. Adams, F. Xue, R. M. Dell, S. M. Ott, S. Silverman, J. C. Giaconi, C. W. Critchlow 10.20-11.45 SCIENTIFIC SESSION V Chairpersons: Jean‑Marc Kaufman, Socrates Papapoulos

Auditorium A

10.20-10.50 Auditorium A Plenary Lecture 5 - Is it time to resurrect menopause hormone therapy in Osteoporosis? John C. Stevenson 10.50-11.45 Oral communications selected from abstracts

Auditorium A

10.50-11.00 Auditorium A OC21 COMPARATIVE PERFORMANCE OF CURRENT DEFINITIONS OF SARCOPENIA AGAINST THE PROSPECTIVE INCIDENCE OF FALLS AMONG COMMUNITYDWELLING SENIORS AGE 65 AND OLDER Presenting author: H. A. Bischoff‑Ferrari Authors: E. J. Orav, J. A. Kanis, R. Rizzoli, M. Schlögl, H. B. Staehelin, W. C. Willett, B. Dawson‑Hughes 11.00-11.10 Auditorium A OC22 PHASE 2 RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED TRIAL OF MYOSTATIN ANTIBODY IN OLDER FALLERS WITH LOW MUSCLE STRENGTH Presenting author: S. Ferrari Authors: C. Becker, S. R. Lord, S. Studenski, S. J. Warden, R. Fielding, C. Recknor, M. C. Hochberg, H. Blain, E. F. Binder, Y. Rolland, S. Poiraudeau, C. T. Benson, S. L. Myers, L. Hu, Q. Ahmad, K. Pacuch, E. Gomez, O. Benichou 11.10-11.20 Auditorium A OC23 CORRELATION BETWEEN MUSCLE MASS AND MUSCLE STRENGTH AND THEIR ASSOCIATION WITH PHYSICAL PERFORMANCE AND GAIT SPEED Presenting author: C. Beaudart Authors: J.‑Y. Reginster, J. L. Croisier, J. Slomian, F. Buckinx, M. Locquet, A. Quabron, O. Bruyère 11.20-11.30 Auditorium A OC24 EFFECT OF AGE AND SEX ON JUMPING MECHANOGRAPHY AND OTHER MEASURES OF MUSCLE MASS AND FUNCTION Presenting author: B. Buering Authors: E. Fidler, D. Krueger, R. E. Ward, P. Caserotti, E. S. Strotmeyer, T. B. Harris, N. Binkley 11.30-11.40 Auditorium A OC25 CRITICAL EVALUATION OF PROMISING MARKERS FOR SARCOPENIA Presenting author: E. Cavalier Authors: R. Gadisseur, S. Geboes, A.‑C. Bekaert, A. Carlisi, O. Bruyère, J.‑Y. Reginster

10.00-10.10 Auditorium A OC19 IN VIVO CORTICAL BONE INDENTATION MEASUREMENTS ARE INDEPENDENT OF AGE, BMD AND CORTICAL MORPHOLOGY IN POSTMENOPAUSAL WOMEN Presenting author: J. N. Tsai Authors: E. W. Yu, N. Derrico, A. Martinez‑Betancourt, M. L. Bouxsein

ABSTRACT BOOK

21

FINAL PROGRAMME

SATURDAY MARCH 28, 2015 12.15-13.45 INDUSTRY-SPONSORED LUNCH SYMPOSIUM Auditorium B Dairy products & bone health: turning facts and beliefs into clinical practice Chairpersons: Jean‑Yves Reginster, René Rizzoli - The acid-ash hypothesis and bone health - Tanis Fenton - Dairy consumption, prevention of osteoporosis & fractures: an update Olivier Bruyère - Dairy product facts & fiction - Jean‑Jacques Body 12.15-13.45 Auditorium A INDUSTRY-SPONSORED LUNCH SYMPOSIUM Putting the Patient First: Effective Therapeutic Strategies to Reduce the Burden of Fractures Chairperson: Maria-Luisa Brandi - Welcome & Introduction - Maria-Luisa Brandi - Bridging the Osteoporosis Care Gap: Improving Patient Outcomes with a Fracture Liaison Service - Maria-Luisa Brandi - Understanding the Fragile Patient: Identifying and Addressing the Clinical Challenge - Astrid Fahrleitner-Pammer - Preventing Secondary Osteoporosis: Anabolic vs Anti-resorptive Therapy for Improving Patient Outcomes - Erik Fink Eriksen - Question & Answer. Symposium Close - Maria-Luisa Brandi 14.00-15.03 Oral presentation of selected posters Chairperson: Johanne Martel‑Pelletier

Podium

14.00-14.07 Podium P288 ALENDRONATE IMPROVES BONE MATERIAL LEVEL PROPERTIES IN PAIRED HUMAN TRANSILIAC BONE BIOPSY SPECIMENS Presenting author: P. Ammann Author: R. Rizzoli 14.07-14.14 Podium P199 CLUSTER ANALYSIS OF HIGH RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY PARAMETERS IDENTIFIES BONE PHENOTYPES ASSOCIATED WITH HIGH RATES OF PREVALENT FRACTURE Presenting author: M. H. Edwards Authors: D.E. Robinson, C. Parsons, K. A. Ward, E. M. Dennison, C. Cooper 14.14-14.21 Podium P241 THE EFFECT OF LOCAL ANAESTHETIC INFILTRATION ON CHRONIC POSTSURGICAL PAIN AFTER TOTAL HIP AND KNEE REPLACEMENT: THE APEX RANDOMISED CONTROLLED TRIALS Presenting author: R. Gooberman‑Hill Authors: V. Wylde, E. Lenguerrand, E. Marques, S. Noble, J. Horwood, M. Pyke, P. D. Dieppe, A. W. Blom 14.21-14.28 Podium P265 GRIP FATIGUE RESISTANCE AND SELF-PERCEIVED FATIGUE IN RELATION WITH SARCOPENIA AND QUALITY OF LIFE Presenting author: C. Beaudart Authors: J.‑Y. Reginster, I. Bautmans, J. L. Croisier, J. Slomian, F. Buckinx, M. Locquet, A. Quabron, O. Bruyère 14.28-14.35 Podium P642 SCLEROSTIN ANTIBODY IMPROVES VERTEBRAE PARAMETERS IN MURINE MODEL OF SEVERE OSTEOGENESIS IMPERFECTA Presenting author: J.‑P. Devogelaer Authors: M. Cardinal, A. Dessain, D. Chappard, S. Lafont, T. Roels, M. S. Ominsky, B. Lengelé, C. Nyssen‑Behets, D.H. Manicourt 14.35-14.42 Podium P669 SUBCHONDRAL TIBIAL BONE TEXTURE ANALYSIS PREDICTS KNEE OSTEOARTHRITIS PROGRESSION: DATA FROM THE OSTEOARTHRITIS INITIATIVE Presenting author: T. Janvier Authors: H. Toumi, A. Valery, L. Delsol, R. Jennane, E. Lespessailles

ABSTRACT BOOK

14.42-14.49 Podium P133 TRABECULAR BONE SCORE IN PATIENTS WITH CHRONIC GLUCOCORTICOID OSTEOPOROSIS TREATED WITH ALENDRONATE OR TERIPARATIDE Presenting author: K. G. Saag Authors: D. Agnusdei, D. Hans, L. A. Kohlmeier, K. D. Krohn, E. S. Leib, E. J. Maclaughlin, K. See, C. Simonelli, K. A. Taylor, R. Marcus 14.49-14.56 Podium P551 RADIOGRAPHIC OSTEOARTHRITIS IS LESS STRONGLY ASSOCIATED WITH PHYSICAL PERFORMANCE THAN CLINICAL OSTEOARTHRITIS IN OLDER INDIVIDUALS Presenting author: E. M. Dennison Authors: M. H. Edwards, C. Parsons, A. E. Litwic, C. Cooper, A. Aihie Sayer 14.56-15.03 Podium P447 DROPPING THE BALL AND FALLING OFF OF THE TREATMENT WAGON: FACTORS CORRELATING WITH NONCOMPLIANCE TO SECONDARY FRACTURE PREVENTION PROGRAMS - EXPERIENCE WITH THE OSTEOPOROSIS PATIENT TARGETED AND INTEGRATED MANAGEMENT FOR ACTIVE LIVING (OPTIMAL) PROGRAM IN SINGAPORE Presenting author: M. Chandran Authors: X. F. Huang, M. Tan 14.00-15.00 Poster Viewing Session II (P401-P800)

Poster area

14.00-15.00 Blue 1 INDUSTRY-SPONSORED SATELLITE SYMPOSIUM Old and new treatments for bone diseases Chairperson: Socrates Papapoulos - Vitamin D: Its expanding role in the maintenance of bone health Maria‑Luisa Brandi - New trends in the treatment of algodystrophy - Silvano Adami - Adherence to treatment in osteoporosis: challenges and new scenarios Nicola Napoli EDUCATIONAL LECTURE 2 - How to write a grant? - Ego Seeman

Auditorium B

14.00-15.00 ESCEO SYMPOSIUM Blue 2 European perspective of the new guidelines for the management of Osteoarthritis – focus on SYSADOAs Chairpersons: Jean‑Pierre Devogelaer, Gabriel Herrero‑Beaumont - Introduction and scope of the problem - Marc Hochberg - Glucosamine and chondroitin salts in the management of osteoarthritis in Europe - Jean‑Yves Reginster - Hyaluronic acid salts in the management of Osteoarthritis in Europe Jean‑Pierre Pelletier - Discussion - Leader: Jaime Branco Panel: Jaime Branco, Maria‑Luisa Brandi, Olivier Bruyère, Cyrus Cooper, Jean‑Pierre Devogelaer, Gabriel Herrero‑Beaumont, Marc Hochberg, John A. Kanis, Emmanuel Maheu, Jean‑Pierre Pelletier, Jean‑Yves Reginster, René Rizzoli 14.00-15.00 MEET-THE-EXPERT SESSIONS

Diagnosis and treatment of sarcopenia Marjolein Visser Physical rehabilitation in Musculoskeletal conditions: which method? Olivier Bruyère

Yellow 1 White 1

Use of FRAX worldwide: current challenges and solutions John A. Kanis

Yellow 2

Epidemiology and management of post-menopausal Osteoporosis in the Middle East and Africa Leith Zakraoui

Yellow 3

22

FINAL PROGRAMME

SATURDAY MARCH 28, 2015 14.00-15.00 Monitoring of Osteoporosis treatments Jonathan D. Adachi 15.00-16.40 SCIENTIFIC SESSION VI Chairpersons: Johanne Martel‑Pelletier, Marc Hochberg

White 2

Auditorium A

15.00-15.30 Plenary Lecture 6 Auditorium A - How long should we treat osteoporotic patients? - Maria‑Luisa Brandi 15.30-16.40 Oral communications selected from abstracts

Auditorium A

15.30-15.40 Auditorium A OC26 PROFESSIONAL ACTIVITY-DEPENDENT REPEATED LOADING INFLUENCES CORTICAL BONE GEOMETRY AND STRENGTH Presenting author: E. Biver Authors: G. Perréard Lopreno, M. Hars, S. Ferrari, M. Besse, R. Rizzoli 15.40-15.50 Auditorium A OC27 HIP AXIS LENGTH IS A FRAX AND BONE DENSITY INDEPENDENT RISK FACTOR FOR HIP FRACTURE IN MEN AND WOMEN Presenting author: W. D. Leslie Authors: L. M. Lix, S. N. Morin, H. Johansson, A. Odén, E. V. McCloskey, J. A. Kanis 15.50-16.00 Auditorium A OC28 THE EFFECT OF GLUCOSE-LOAD ON BONE REMODELING MARKERS AND OSTEOBLAST FUNCTION Presenting author: I. Levinger Authors: G. Jerums, G. McConell, M. Rybchyn, S. Cassar, E. Byrnes, P. R. Ebeling, S. Selig, E. Seeman, T. Brennan‑Speranza 16.00-16.10 Auditorium A OC29 IMPAIRED TRABECULAR BONE MICROARCHITECTURE IMPROVES AFTER ONEYEAR ON GLUTEN-FREE DIET: A PROSPECTIVE LONGITUDINAL HR-PQCT STUDY IN WOMEN WITH CELIAC DISEASE Presenting author: M.B. Zanchetta Authors: J. R. Zanchetta, C. Bogado, J. C. Bai, F. Silveira, R. M. Massure, F. Costa 16.10-16.20 Auditorium A OC30 COMBINING MEASUREMENT OF CORTICAL POROSITY AT THE PROXIMAL FEMUR WITH FRAX IMPROVES THE SENSITIVITY AND MAINTAINS HIGH SPECIFICITY FOR FRACTURE Presenting author: M. Osima Authors: R. Joakimsen, R. M. Joakimsen, E. F. Eriksen , Å. Bjørnerem 16.20-16.30 Auditorium A OC31 WHAT TRIGGERS OSTEOPOROSIS THERAPY IN HIGH RISK RESIDENTS LIVING IN LONG TERM CARE (LTC) HOMES? THE GAINING OPTIMAL OSTEOPOROSIS ASSESSMENTS IN LONG-TERM CARE (GOAL) STUDY Presenting author: G. Ioannidis Authors: D. O'donnell, C. Kennedy, H. Navare, L. M. Giangregorio, A. M. Cheung, S. Marr, R. G. Crilly, S. Feldman, R. Jain, S. Jamal, R. G. Josse, S. Prasad, L. Thabane, J. D. Adachi, A. Papaioannou 16.30-16.40 Auditorium A OC32 CONCORDANCE BETWEEN MUSCLE MASS ASSESSED BY BIOELECTRICAL IMPEDANCE ANALYSIS AND BY DUAL ENERGY X-RAY ABSORPTIOMETRY AMONG ELDERLY PEOPLE: A CROSS-SECTIONAL STUDY Presenting author: F. Buckinx Authors: J.‑Y. Reginster, N. Dardenne, J. L. Croisier, J. F. Kaux, C. Beaudart, J. Slomian, O. Bruyère

ABSTRACT BOOK

15.00-16.50 COMMITTEE OF NATIONAL SOCIETIES SPECIAL PLENARY SESSION Healthy Life, Healthy Bones Chairpersons: Jean‑Yves Reginster, Judy Stenmark - Introduction - J. Stenmark

Yellow 1

15.03-15.11 Yellow 1 OCs1 HEALTHY LIFE, HEALTHY BONES Presenting author: M. Tsagareli Authors: E. Giorgadze, N. Dolidze, T. Sulikashvili, N. Jeiranashvili 15.11-15.19 Yellow 1 OCs2 A POPULATION-BASED ANALYSIS OF THE POST-FRACTURE CARE GAP IN HONG KONG: THE SITUATION IS NOT IMPROVING Presenting author: A. W. H. Ho Author: S. H. Wong 15.19-15.27 Yellow 1 OCs3 "LET'S HOLD THE BONE TOGETHER": ORTHOPEDIC-METABOLIC COLLABORATIVE MANAGEMENT FOR OSTEOPOROTIC HIP FRACTURE Presenting author: P. Rotman‑Pikielny Authors: M. Frankel, O. Tel‑Levanon, M. Tamar, E. Yakobi, D. Nabriski, D. Netzer, Y. Brin, M. Niska 15.27-15.35 Yellow 1 OCs4 HANDGRIP STRENGTH PREDICTS ABILITY TO FUNCTION IN ACTIVITIES OF DAILY LIVING: A PROSPECTIVE STUDY OF 193 WOMEN WITH HIP FRACTURE Presenting author: M. Di Monaco Authors: C. Castiglioni, E. De Toma, L. Gardin, S. Giordano, R. Tappero 15.35-15.43 Yellow 1 OCs5 RECENT TREND IN THE INCIDENCE OF HIP FRACTURE IN TOTTORI, JAPAN Presenting author: H. H. Hagino Authors: Y. T. Tsukutani, M. O. Osaki, N.H. Nagashima 15.43-15.51 Yellow 1 OCs6 ACCUMULATED ONE YEAR HEALTH UTILITY LOSS AFTER SUSTAINING A HIP FRACTURE IN MEXICO Presenting author: P. Clark Authors: L. Girant, F. Carlos, A. Svedbom, F. Borgström, J. A. Kanis 15.51-15.59 Yellow 1 OCs7 RHEUMATOID CACHEXIA, OSTEOPOROSIS AND VERTEBRAL FRACTURES Presenting author: A EL Maghraoui Authors: S. Sadni, A. Rezqi, A. Bezza, L. Achemlal, A. Mounach 15.59-16.07 Yellow 1 OCs8 PSYCHOLOGICAL WELL BEING AND QUALITY OF LIFE ASSESSMENT OF WORKING WOMEN WITH OSTEOPOROSIS VERSUS RETIRED WOMEN WITH OSTEOPOROSIS Presenting author: D. M. Farcas Authors: F. Marc, C. Suteu, A. I. Gasparik, L. Sachelarie 16.07-16.15 Yellow 1 OCs9 CAFFEINE, COFFEE AND TEA IN RELATION TO RISK OF HIP FRACTURE IN THE SINGAPORE CHINESE HEALTH STUDY Presenting author: W. P. Koh Author: Z. J. Dai 16.15-16.23 OCs10 RISK FACTOR FOR THE FIRST-INCIDENT HIP FRACTURE IN POSTMENOPAUSAL WOMEN Presenting author: F. Chen

Yellow 1

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FINAL PROGRAMME

SATURDAY MARCH 28, 2015 16.23-16.31 OCs11 Yellow 1 NATIONAL BONE HEALTH ALLIANCE: A MULTISECTOR PUBLIC-PRIVATE PARTNERSHIP WORKING TOGETHER TO IMPROVE AMERICA'S BONE HEALTH Presenting author: D. Lee 16.31-16.39 OCs12 Yellow 1 OVERWEIGHT AND OBESITY AND RISK FRACTURE STUDY IN POSTMENOPAUSAL WOMEN FROM HAVANA AND MADRID Presenting author: M. Diaz Curiel Authors: D. Navarro Despaigne, C. Prado Martinez 16.40-16.50 Presentation of the IOF Committee of National Societies Medal Jean‑Yves Reginster

Yellow 1

17.00-18.00 ESCEO-EUGMS SYMPOSIUM

Can we identify which patients should be treated in Osteoarthritis? Blue 1 Chairpersons: Johanne Martel‑Pelletier, Olivier Bruyère - Welcome and introduction - Marc Hochberg - The need for phenotyping patients in Osteoarthritis - Nigel K. Arden - Is it possible to phenotype patients in Osteoarthritis? - Olivier Bruyère - Discussion - Wrap up and conclusions - Olivier Bruyère Panel: Nigel K. Arden, Francis Berenbaum, Jaime Branco, Maria‑Luisa Brandi, Olivier Bruyère, Philip Conaghan, Cyrus Cooper, Elaine M. Dennison, Jean‑Pierre Devogelaer, Gabriel Herrero‑Beaumont, Marc Hochberg, John A. Kanis, Stefania Maggi, Johanne Martel‑Pelletier, Jean‑Pierre Pelletier, Susanne Reiter‑Niesert, Jean‑Yves Reginster, René Rizzoli IOF WORKSHOP Blue 2 ISCD-IOF Joint Session: Latest trends on secondary fracture prevention Chairpersons: Neil Binkley, Kristina Akesson - Capture the fracture -update - Cyrus Cooper - Novel diagnostic technologies - H.P. Dimai - Laboratory Work-up Post Hip Fracture Repair, What to Measure and When, the Impact of Surgery on Laboratory Results - Neil Binkley 17.00-18.30 Auditorium B INDUSTRY-SPONSORED SATELLITE SYMPOSIUM Hypophosphatasia: a rare disease with heterogeneous presentation Chairpersons: Maria‑Luisa Bianchi, Maria‑Luisa Brandi - Opening Remarks - Maria‑Luisa Brandi - Introduction - Maria‑Luisa Bianchi - Characterizing the burden of disease in patients with HPP - Thomas Weber - Clinical presentation of HPP in a family with the same mutation: heterogeneous or homogeneous phenotype? - Francesco Conti - Differentiating HPP from other musculoskeletal diseases - Christian Roux 17.00-18.30 Auditorium A INDUSTRY-SPONSORED SATELLITE SYMPOSIUM Managing Long-Term Osteoporosis: New Insights Chairpersons: Serge Ferrari, Ego Seeman - Welcome and introduction - Serge Ferrari - Efficacy and safety of long-term therapy with denosumab - Socrates Papapoulos - Target for osteoporosis therapy: Supportive evidence from the FREEDOM extension Serge Ferrari - Explaining the differences in long-term BMD gains across therapies - Ego Seeman 18.00-20.00 EUGMS ESCEO ESPEN IOF SYMPOSIUM-BY INVITATION ONLY Identifying cohorts for sarcopenia study

ABSTRACT BOOK

Room 6

24

FINAL PROGRAMME

SUNDAY MARCH 29, 2015 08.00-09.00 NON-SPONSORED SYMPOSIUM

Clinical Application of Bone Microindentation Blue 1 Chairperson: Adolfo Diez‑Perez - Introduction to in vivo Microindentation - Mary L. Bouxsein - Microindentation in diabetes and stress fractures Erik Fink Eriksen - Microindentation in patients with osteopenia and fractures and in Osteoporosis - Socrates Papapoulos Yellow 2 Osteogenic Loading, Low-Impact, High Loading stimulus for Bone Density Development Chairperson: John Jaquish - Introduction to impact forces, risks and rewards - Riku Nikander - Osteogenic loading and functional bone performance John Jaquish - Neural inhibition and safety in static loading - Lynn Freeman

Links between atherosclerosis and osteoporosis Chairpersons: Sekib Sokolovic, Roberto Jacomelli, Almira Hadzovic‑Dzuvo - Atherosclerosis: Degenerative or Inflammatory disease Dragan Lovic - Osteoporosis: Degenerative or Inflammatory disease Ülke Akarirmak - Atherosclerosis and Osteoporosis: Is there any link? Sekib Sokolovic

Blue 2

Non-holiday drug for osteoporosis. Is it possible Yellow 1 to calculate the economic impact of anti fracture efficacy versus side effect ? Chairperson: Elio Tanaka - Introduction - Elio Tanaka - The drugs for osteoporosis , past , present and future Fernanda Tanaka - The anti fracture efficacy and the adverse effects of the osteoporosis´drugs . - Claudia Totsugui Mariano - The economic impact of anti fracture efficacy versus side or adverse effects - Alexander Itria - The drug for bone event specialy in dismetabolic patients , like chronic kidney failure group of patients - Fabiana Gatti de Menezes - Questions and closing remarks - Elio Tanaka 09.00-11.10 SCIENTIFIC SESSION VII Chairpersons: Roger Fielding, Nicholas Harvey

Auditorium B

09.00-09.30 Plenary Lecture 7 - Inflammation and bone fragility - Christian Roux

Auditorium B

09.30-09.40 Presentation of the IOF Olof Johnell Science Award René Rizzoli

Auditorium B

09.40-10.40 Oral communications selected from abstracts

10.00-10.10 Auditorium B OC35 REDUCED FRACTURE RISK IN DANISH WOMEN WITH POLYCYSTIC OVARY SYNDROME: A NATIONAL REGISTER-BASED COHORT STUDY Presenting author: K. H. Rubin Authors: D. Glintborg, M. Nybo, M. Andersen, B. Abrahamsen 10.10-10.20 Auditorium B OC36 IMPACT OF HIP FRACTURE ON HOSPITAL CARE COSTS: A POPULATION BASED STUDY Presenting author: J. Leal Authors: A. M. Gray, M. K. Javaid, D. Prieto‑Alhambra, N. K. Arden, C. Cooper, A. Judge 10.20-10.30 Auditorium B OC37 A SYSTEMATIC REVIEW OF THE USE OF SPINAL ORTHOSES IN THE MANAGEMENT OF VERTEBRAL OSTEOPOROSIS AND OSTEOPOROTIC VERTEBRAL FRACTURE Presenting author: K. L. Barker Authors: C. Minns Lowe, M. Newman 10.30-10.40 Auditorium B OC38 EFFICACY STUDY OF THE TREATMENT OF OSTEOARTHRITIS-INDUCED KNEE PAIN WITH AUTOLOGOUS CONDITIONED SERUM: A COMPARATIVE, PROSPECTIVE AND RANDOMIZED STUDY Presenting author: D. W. Hang 10.40-11.10 Auditorium B Plenary Lecture 8 - Guideline diversity in glucocorticoid-induced Osteoporosis - Cyrus Cooper 11.10-12.10 ESCEO SYMPOSIUM Auditorium B G uidelines for the registration of drugs to be used in frailty and sarcopenia Chairpersons: Alfonso Cruz Jentoft, Marjolein Visser - Introduction - René Rizzoli - Who should we treat in Sarcopenia - Antonio Cherubini - How to assess diseases in Sarcopenia - Roger Fielding - Discussion leaders - Ivan Bautmans - Luc J. C. van Loon - Conclusion - Jean‑Yves Reginster Panel: Islene Araujo de Carvalho (World Health Organization – Geneva), Ivan Bautmans, Heike A. Bischoff‑Ferrari, Maria‑Luisa Brandi, Olivier Bruyère, Etienne Cavalier, Antonio Cherubini, Cyrus Cooper, Gaetano Crepaldi, Alfonso Cruz Jentoft, Roger Fielding, John A. Kanis, Alberto Pilotto, Jean‑Yves Reginster, Susanne Reiter‑Niesert, René Rizzoli, Serge Rozenberg

Auditorium B

09.40-09.50 Auditorium B OC33 SAFETY AND EFFICACY OF ODANACATIB IN THE TREATMENT OF MEN WITH OSTEOPOROSIS: A RANDOMIZED PLACEBO-CONTROLLED TRIAL Presenting author: R. D. Chapurlat Authors: E. S. Orwoll, S. Adami, N. Binkley, B. L. Langdahl, S. Doleckyj, H. Giezek, B. B. Scott, A. C. Santora 09.50-10.00 Auditorium B OC34 FRAX-BASED ASSESSMENT AND INTERVENTION THRESHOLDS: AN EXPLORATION OF THRESHOLDS IN WOMEN AGED 50 YEARS AND OLDER IN THE UK Presenting author: N. C. Harvey Authors: J. A. Kanis, H. Johansson, A. Odén, A. Cooper, C. Cooper, R. M. Francis, D. M. Reid, P. Selby, J. E. Compston, E. V. McCloskey

ABSTRACT BOOK

25

FINAL PROGRAMME

SPONSORED SATELLITE SYMPOSIA T hu r s d ay , M ar c h 2 6

Satu r d ay , M ar c h 2 8

18.50-19.50 IOF-ESCEO-SERVIER HONORARY LECTURE Fondazione Stelline - Historical genetics of wine grapes - José Vouillamoz

12.15-13.45 Auditorium B CERIN / CNIEL, EMF, GDP LUNCH SYMPOSIUM Dairy products & bone health: turning facts and beliefs into clinical practice Chairpersons: Jean‑Yves Reginster, René Rizzoli - The acid-ash hypothesis and bone health - Tanis Fenton - Dairy consumption, prevention of osteoporosis & fractures: an update Olivier Bruyère - Dairy product facts & fiction - Jean‑Jacques Body

20.05-21.05 MEDA AB WELCOME COCKTAIL

Fondazione Stelline

F r i d ay , M ar c h 2 7 12.15-13.45 MEDA AB LUNCH SYMPOSIUM Auditorium A ESCEO Algorithm for Osteoarthritis: from treatment guidelines to real life Chairpersons: Maurizio Cutolo, Jean‑Yves Reginster - Biological and clinical effects of intra-articular hyaluronic acid: metaanalyses and real-life patient studies - Thierry Conrozier - Prevention and treatment of knee osteoarthritis with glucosamine sulfate: from clinical studies to real life. - Lucio C. Rovati - How can we help implementing ESCEO algorithm in real life Jean‑Yves Reginster 12.15-13.45 Auditorium B TAKEDA LUNCH SYMPOSIUM Calcium and vitamin D – Fact and fiction Chairperson: John A. Kanis - Welcome and introduction - John A. Kanis - Efficacy of calcium and vitamin D supplementation: Where are we now? - Cyrus Cooper - Calcium and vitamin D supplementation: Update on safety profile René Rizzoli - Bone protective therapies with and without calcium and vitamin D – Does it matter? - Bess Dawson‑Hughes - Meeting summary and close - John A. Kanis 17.00-18.30 Auditorium B MSD SATELLITE SYMPOSIUM Evolving Strategies for Management of Osteoporosis Chairperson: Silvano Adami - Opening Remarks - Silvano Adami - The Role of Cathepsin K in Bone Homeostasis - Ego Seeman - Odanacatib Antifracture Efficacy in Postmenopausal Women; Results From the Phase 3 Long-term Odanacatib Fracture Trial (LOFT) Michael R. McClung - Safety and Tolerability of Odanacatib in Post-Menopausal Women; Interim Results From the Phase 3 Long-term Odanacatib Fracture Trial (LOFT) - Socrates Papapoulos - Closing - Panel Question and Answer - Silvano Adami 17.00-18.30 Blue 1 SERVIER SATELLITE SYMPOSIUM Management of severe osteoporosis: personnalized medicine in practice Chairpersons: Maria‑Luisa Brandi, Jean‑Yves Reginster - Introduction - Maria‑Luisa Brandi - Why is severe Osteoporosis still an unmet medical need 40 years after the discovery of the first drugs? - Maria‑Luisa Brandi - Management of patients contra-indicated or not tolerant to antiresorptive treatments - René Rizzoli - New indication and safety of strontium ranelate: a comprehensive review - Cyrus Cooper - Conclusion - Jean‑Yves Reginster

ABSTRACT BOOK

12.15-13.45 ELI LILLY LUNCH SYMPOSIUM Auditorium A Putting the Patient First: Effective Therapeutic Strategies to Reduce the Burden of Fractures Chairperson: Maria-Luisa Brandi - Welcome & Introduction - Maria-Luisa Brandi - Bridging the Osteoporosis Care Gap: Improving Patient Outcomes with a Fracture Liaison Service - Maria-Luisa Brandi - Understanding the Fragile Patient: Identifying and Addressing the Clinical Challenge - Astrid Fahrleitner-Pammer - Preventing Secondary Osteoporosis: Anabolic vs Anti-resorptive Therapy for Improving Patient Outcomes - Erik Fink Eriksen - Question & Answer. Symposium Close - Maria-Luisa Brandi 14.00-15.00 ABIOGEN SATELLITE SYMPOSIUM Blue 1 Old and new treatments for bone diseases Chairperson: Socrates Papapoulos - Vitamin D: Its expanding role in the maintenance of bone health Maria‑Luisa Brandi - New trends in the treatment of algodystrophy - Silvano Adami - Adherence to treatment in osteoporosis: challenges and new scenarios Nicola Napoli 17.00-18.30 Auditorium A AMGEN SATELLITE SYMPOSIUM Managing Long-Term Osteoporosis: New Insights Chairpersons: Serge Ferrari, Ego Seeman - Welcome and introduction - Serge Ferrari - Efficacy and safety of long-term therapy with denosumab Socrates Papapoulos - Target for osteoporosis therapy: Supportive evidence from the FREEDOM extension - Serge Ferrari - Explaining the differences in long-term BMD gains across therapies Ego Seeman 17.00-18.30 Auditorium B ALEXION SATELLITE SYMPOSIUM Hypophosphatasia: a rare disease with heterogeneous presentation Chairpersons: Maria‑Luisa Bianchi, Maria‑Luisa Brandi - Opening Remarks - Maria‑Luisa Brandi - Introduction - Maria‑Luisa Bianchi - Characterizing the burden of disease in patients with HPP Thomas Weber - Clinical presentation of HPP in a family with the same mutation: heterogeneous or homogeneous phenotype? - Francesco Conti - Differentiating HPP from other musculoskeletal diseases - Christian Roux

26

Bone Research Society Events BONE RESEARCH SOCIETY TRAINING COURSE

ORGANISERS

Tash Masud (Nottingham) Jon Tobias (Bristol)

OXFORD, UK 13-15 APRIL 2015 This annual 3-day residential training course provides trainees in medical specialties such as rheumatology, endocrinology, care of the elderly, gastroenterology, orthopaedics, respiratory medicine and clinical chemistry with the knowledge and understanding to manage patients with osteoporosis and other metabolic bone diseases. The course focuses on practical issues relating to patient management and is strongly recommended for any trainee who foresees that patients with these disorders will form a significant part of their workload in future. Specialist nurses in osteoporosis and falls will also find this course valuable, as well as newly qualified consultants or others wishing to update their knowledge. To join our mailing list, please contact [email protected].

SOME COMMENTS FROM THOSE WHO ATTENDED PREVIOUS COURSES:

“ Fantastic course, probably the best I have ever been on” “ Brilliant course set at the right level, knowledgeable speakers, will definitely recommend it” “ Very useful, inspiring course … represents great value for money in terms of both quality and quantity of teaching … I will certainly be recommending this course”

BRS/BSMB 3rd JOINT MEETING 1-3 SEPTEMBER 2015 EDINBURGH, UK ORGANISERS Tom Van Agtmael (CO-CHAIR) Vicky MacRae (CO-CHAIR) Stuart Ralston (CO-CHAIR) Faisal Ahmed David Hamilton Hamish Simpson Katherine Staines

PROGRAMME HIGHLIGHTS SYMPOSIA TO INCLUDE:

Autoimmunity Cell signalling in the kidney Genetics of musculoskeletal diseases Matrix diseases Mineralisation

Both events endorsed by

Muscle and bone Osteoporosis Paget’s disease Scaffolds Stem cells and regenerative medicine Vitamin D

For more information please visit our website or email [email protected]

Bone Research Society www.brsoc.org.uk

ALSO

Clinical cases New Investigator session Rare bone diseases workshop