DOI: 10.7860/JCDR/2014/10125.4731

Case Report

Pathology Section

Vulvar Syringoma: A Rare Case Report Sarita Nibhoria1, Kanwardeep Kaur Tiwana2, Ashish Yadav3

ABSTRACT Syringoma is a benign eccrine sweat gland tumour affecting mostly females at puberty as multiple soft papules usually 1-2 mm in diameter. The sites of predilection are lower eyelids, cheeks. Syringoma of the vulva is a rare disorder. Only few cases have been reported in the literature. We report here a case of 46-year-old female who presented to gynecology department with vulvar papules associated with vulvar itching and burning since two years. Microscopic examination of the punch biopsy revealed numerous small ducts lined by two layers of epithelial cells embedded in a fibrous stroma. Some of the ducts showed small comma like tails of epithelial cells imparting them a tadpole shape. Despite being a rare diagnosis, vulvar syringoma should be kept in differential diagnosis with vulvar pruritus

Keywords: Pruritus, Syringoma, Vulva

Case report

Discussion

A 46-year-old female presented to gynecology department with complaints of severe vulvar itching and burning since two years. On examination, multiple small papules were present on the labia majora. Punch biopsy of the vulvar lesion was taken and histopathological examination revealed numerous small ducts lined by double layer of epithelial cells embedded in a fibrous stroma [Table/Fig-1]. The lumina of some of the ducts contained amorphous debris. Some ducts had tadpole like shape [Table/Fig-2]. Based on histopathologic findings, the diagnosis of vulvar syringoma was made.

Syringoma is a benign adnexal tumour which was first described by Kaposi and Biesiadeki in 1872 [1]. Based on histochemical and electron microscopic findings, the cell of origin of this tumour is intraepidermal eccrine sweat glands [2]. Syringoma is more common in females presenting during adolescence, and most commonly involving the lower eyelid of the face. Other sites of predilection are the cheeks, thighs, axillae and abdomen. Genital syringomas are rare and usually asymptomatic [3]. It can undergo cyclic changes in its size and symptoms presenting during the premenstrual period, pregnancy and with the use of oral contraceptives [1,4]. Syringoma occurs sporadically or it can, on rare occasion, have a hereditary aetiology. Syringoma appears to be more common in patients with Marfan, Down and Ehler’s- Danlos syndromes [4].

Conclusion Vulvar syringoma although rare entity should be kept in differential diagnosis of pruritic lesions of the vulva.

References [Table/Fig-1]: Sections show numerous small ducts lined by two layers of epithelial cells embedded in a fibrous stroma (H& E X100) [Table/Fig-2]: Sections show ducts arranged as small comma like tails of epithelial cells imparting them a tadpole shape (H&E X100)

[1] Choi HJ, Lee YJ, Park SH, Kim HU, et al. A case of vulvar syringoma with pruritus. Korean J Dermatol. 2005;43:291-93. [2] Lever’s histopathology of the skin, 10th Ed. pg. 884-85. [3] Tay YK, Tham SN, Teo R. Localized vulvar syringoma- an unusual cause of pruritus vulvae. Dermatology. 1996;192(1):62-3. [4] Turan C, Vyur M, Kutlvay, et al .Vulvar syringoma exacerbation during pregnancy. Eur. J. Obstet.Gynaecol Reprod Biol. 1996;64:141-42.



PARTICULARS OF CONTRIBUTORS: 1. Associate Professor, Department of Pathology, Guru Gobind Singh Medical College Faridkot Punjab, India. 2. Associate Professor, Department of Pathology, Guru Gobind Singh Medical College Faridkot Punjab, India. 3. Junior Resident, Department of Pathology, Guru Gobind Singh Medical College Faridkot Punjab, India NAME, ADDRESS, E-MAIL ID OF THE CORRESPONDING AUTHOR: Dr. Kanwardeep Kaur Tiwana, H.No. 75 Medical College Campus Faridkot, Punjab-151203, India. Phone : 09815991588 , E-mail : [email protected] Financial OR OTHER COMPETING INTERESTS: None.

6

Date of Submission: May 28, 2014 Date of Peer Review: Jun 27, 2014 Date of Acceptance: Jul 14, 2014 Date of Publishing: Aug 20, 2014

Journal of Clinical and Diagnostic Research. 2014 Aug, Vol-8(8): FD06

Copyright of Journal of Clinical & Diagnostic Research is the property of JCDR Research & Publications Private Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.

Vulvar syringoma: a rare case report.

Syringoma is a benign eccrine sweat gland tumour affecting mostly females at puberty as multiple soft papules usually 1-2 mm in diameter. The sites of...
565KB Sizes 0 Downloads 6 Views

Recommend Documents


Fine-needle aspiration cytology of chondroid syringoma of fore arm: Report of a rare case.
Chondroid syringoma is a rare benign adnexal tumor of sweat glands with microscopic resemblance to the salivary gland pleomorphic adenoma. Cytology is rarely utilized for preoperative assessment of these slow-growing, small, nodular lesions. Definiti

Vulvar lipoma: a case report.
Vulvar lipoma is a rare tumor localization and only a few cases have been reported. The clinical characteristics of vulvar lipoma are well known. However, it is important to distinguish lipomas from liposarcomas. We report a case of vulvar lipoma and

Amelanotic vulvar melanoma: a case report.
A 14-year-old girl stated that she has vulvar pruritus, pain, and bleeding and underwent a complete gynecological evaluation during which a suspicious 2-cm achromic lesion on her vulva was observed. Initially, it was suspected to be a pyogenic granul

Vulvar hemangiopericytoma: A case report and literature review.
► Most solitary fibrous tumors (SFTs) are benign tumors, but some behave more aggressively. ► Correlation between pathologic grading and clinical behavior is poor but immunohistochemical profiles may be of use. ► Most disease is limited to site of or

Extremely rare case of vulvar myxoid epithelioid sarcoma.
Epithelioid sarcoma is a distinct sarcoma type with specific morphology and immunophenotype. An epithelioid sarcoma of the vulva is an extremely rare and aggressive tumor and most commonly occurs on the labia majora in women of reproductive age. Only

Chondroid Syringoma of the Foot: A Rare Diagnosis.
Chondroid syringoma is a rare tumor with the potential for malignant transformation and distant metastasis. The site of predilection for benign chondroid syringoma is the head and neck region, and it is less likely to involve the foot. In contrast, m

Malignant chondroid syringoma in a West African cancer institute: A case report.
To report a case of malignant chondroid syringoma, a rare skin tumor at Joliot Curie Cancer Institute in Dakar.

Dioctophymiasis: A Rare Case Report.
Dioctophyma renale commonly known as "giant kidney worm' is found in the kidney of carnivorous mammals. Human infestation is rare, but results in destruction of the kidneys. Very few cases have been reported worldwide. We are here reporting a case of