Advanced Pharmaceutical Bulletin
Adv Pharm Bull, 2015, 5(2), 231-236 doi: 10.15171/apb.2015.032 http://apb.tbzmed.ac.ir
Research Article
Voluntary Exercise Protects Heart from Oxidative Stress in Diabetic Rats Roya Naderi, Gisou Mohaddes*, Mustafa Mohammadi*, Rana Ghaznavi, Rafigheh Ghyasi, Amir Mansour Vatankhah Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran. Article info Article History: Received: 15 April 2014 Revised: 23 July 2014 Accepted: 26 July 2014 ePublished: 1 June 2015
Keywords: Oxidative Stress Diabetes Voluntary running wheel Heart
Abstract Purpose: Oxidative stress plays a key role in the onset and development of diabetes complications. In this study, we evaluated whether voluntary exercise could alleviate oxidative stress in the heart and blood of streptozotocin - induced diabetic rats. Methods: 28 male Wistar rats were randomly divided into four groups (n=7): control, exercise, diabetes and exercise + diabetes. Diabetes was induced by injection of streptozotocin in male rats. Rats in the trained groups were subjected to voluntary running wheel exercise for 6 weeks. At the end of six weeks blood and heart tissue samples were collected and used for determination of antioxidant enzymes (including SOD, GPX and CAT activities) and MDA level. Results: Exercise significantly reduced MDA levels both in the heart tissue (p
Adv Pharm Bull, 2015, 5(2), 231-236 doi: 10.15171/apb.2015.032 http://apb.tbzmed.ac.ir
Research Article
Voluntary Exercise Protects Heart from Oxidative Stress in Diabetic Rats Roya Naderi, Gisou Mohaddes*, Mustafa Mohammadi*, Rana Ghaznavi, Rafigheh Ghyasi, Amir Mansour Vatankhah Drug Applied Research Center of Tabriz University of Medical Sciences, Tabriz, Iran. Article info Article History: Received: 15 April 2014 Revised: 23 July 2014 Accepted: 26 July 2014 ePublished: 1 June 2015
Keywords: Oxidative Stress Diabetes Voluntary running wheel Heart
Abstract Purpose: Oxidative stress plays a key role in the onset and development of diabetes complications. In this study, we evaluated whether voluntary exercise could alleviate oxidative stress in the heart and blood of streptozotocin - induced diabetic rats. Methods: 28 male Wistar rats were randomly divided into four groups (n=7): control, exercise, diabetes and exercise + diabetes. Diabetes was induced by injection of streptozotocin in male rats. Rats in the trained groups were subjected to voluntary running wheel exercise for 6 weeks. At the end of six weeks blood and heart tissue samples were collected and used for determination of antioxidant enzymes (including SOD, GPX and CAT activities) and MDA level. Results: Exercise significantly reduced MDA levels both in the heart tissue (p
