Author's Accepted Manuscript
Vitamin K1 MONITORING in pregnancies after bariatric surgery: a prospective cohort study Goele Jans MS, Isabelle Guelinckx PhD, Willy Voets MD, PhD, Sander Galjaard MD, Paul M.M. Van Haard PhD, Greet M. Vansant PhD, Roland Devlieger MD, PhD
www.elsevier.com/locate/buildenv
PII: DOI: Reference:
S1550-7289(14)00214-7 http://dx.doi.org/10.1016/j.soard.2014.04.032 SOARD2010
To appear in:
Surgery for Obesity and Related Diseases
Cite this article as: Goele Jans MS, Isabelle Guelinckx PhD, Willy Voets MD, PhD, Sander Galjaard MD, Paul M.M. Van Haard PhD, Greet M. Vansant PhD, Roland Devlieger MD, PhD, Vitamin K1 MONITORING in pregnancies after bariatric surgery: a prospective cohort study, Surgery for Obesity and Related Diseases, http://dx.doi.org/ 10.1016/j.soard.2014.04.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
VITAMIN K1 MONITORING IN PREGNANCIES AFTER BARIATRIC SURGERY: A PROSPECTIVE COHORT STUDY
Goele Jans1 (MS), Isabelle Guelinckx2 (PhD), Willy Voets3 (MD, PhD), Sander Galjaard (MD)1-4, Paul M.M. Van Haard4 (PhD)5, Greet M. Vansant2 (PhD), Roland Devlieger1,4 (MD, PhD) 1
2
Department of Development and Regeneration, Unit Pregnancy, Fetus and Newborn, KU Leuven, Belgium Department of Public Health and Primary Care; Environment and Health, section nutrition, KU Leuven,
Belgium 3
Jessa Hospital Hasselt, Belgium
4
Department of Obstetrics and Gynecology, University Hospitals Leuven, Belgium
5
Department of Medical Laboratories/Diagnostic Centre SSDZ, Reinier de Graaf Group of Hospitals,
Association of Clinical Chemistry, Delft, the Netherlands
Funding: I. Guelinckx was funded by a post-doctoral grant from KU Leuven (2010-2011). R. Devlieger is recipient of a post-doctoral research grant from FWO Flanders (2010-2015). Corresponding author:
Roland Devlieger, MD, PhD Department of Obstetrics and Gynecology University Hospitals Leuven Herestraat 49, B-3000 Leuven, Belgium Phone: +3216344204, Fax: +3216344205 [email protected]
Acknowledgments: RD, IG, WV, SG and GV designed research. RD and IG conducted research; GJ analyzed data and wrote the paper. GJ and RD had primary responsibility for final content. All authors read and approved the final manuscript. No conflicts of interests are disclosed. Running foot:
pregnancy after bariatric surgery: vitamin K1
VITAMIN K1 MONITORING IN PREGNANCIES AFTER BARIATRIC SURGERY: A PROSPECTIVE COHORT STUDY
ABSTRACT Background: Neonatal intracranial bleedings and birth defects have been reported, possibly related to maternal vitamin K1 deficiency during pregnancy following bariatric surgery. Objective: To investigate the effects of screening and supplementation on K1 serum levels in pregnant women with bariatric surgery, and to compare K1 levels and prothrombin time (PT %) in the first trimester with pregnant women without bariatric surgery. Setting: One university and 4 peripheral hospitals Methods: A prospective cohort study including 49 pregnant women with bariatric surgery. Nutritional deficiencies were prospectively screened. In case of observed low K1 serum levels, supplementation was provided. K1 serum levels and PT (%) during the first trimester were compared with a non-surgical control group of 27 women. Results: During the first trimester, most women had low K1 serum levels (
Vitamin K1 MONITORING in pregnancies after bariatric surgery: a prospective cohort study Goele Jans MS, Isabelle Guelinckx PhD, Willy Voets MD, PhD, Sander Galjaard MD, Paul M.M. Van Haard PhD, Greet M. Vansant PhD, Roland Devlieger MD, PhD
www.elsevier.com/locate/buildenv
PII: DOI: Reference:
S1550-7289(14)00214-7 http://dx.doi.org/10.1016/j.soard.2014.04.032 SOARD2010
To appear in:
Surgery for Obesity and Related Diseases
Cite this article as: Goele Jans MS, Isabelle Guelinckx PhD, Willy Voets MD, PhD, Sander Galjaard MD, Paul M.M. Van Haard PhD, Greet M. Vansant PhD, Roland Devlieger MD, PhD, Vitamin K1 MONITORING in pregnancies after bariatric surgery: a prospective cohort study, Surgery for Obesity and Related Diseases, http://dx.doi.org/ 10.1016/j.soard.2014.04.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
VITAMIN K1 MONITORING IN PREGNANCIES AFTER BARIATRIC SURGERY: A PROSPECTIVE COHORT STUDY
Goele Jans1 (MS), Isabelle Guelinckx2 (PhD), Willy Voets3 (MD, PhD), Sander Galjaard (MD)1-4, Paul M.M. Van Haard4 (PhD)5, Greet M. Vansant2 (PhD), Roland Devlieger1,4 (MD, PhD) 1
2
Department of Development and Regeneration, Unit Pregnancy, Fetus and Newborn, KU Leuven, Belgium Department of Public Health and Primary Care; Environment and Health, section nutrition, KU Leuven,
Belgium 3
Jessa Hospital Hasselt, Belgium
4
Department of Obstetrics and Gynecology, University Hospitals Leuven, Belgium
5
Department of Medical Laboratories/Diagnostic Centre SSDZ, Reinier de Graaf Group of Hospitals,
Association of Clinical Chemistry, Delft, the Netherlands
Funding: I. Guelinckx was funded by a post-doctoral grant from KU Leuven (2010-2011). R. Devlieger is recipient of a post-doctoral research grant from FWO Flanders (2010-2015). Corresponding author:
Roland Devlieger, MD, PhD Department of Obstetrics and Gynecology University Hospitals Leuven Herestraat 49, B-3000 Leuven, Belgium Phone: +3216344204, Fax: +3216344205 [email protected]
Acknowledgments: RD, IG, WV, SG and GV designed research. RD and IG conducted research; GJ analyzed data and wrote the paper. GJ and RD had primary responsibility for final content. All authors read and approved the final manuscript. No conflicts of interests are disclosed. Running foot:
pregnancy after bariatric surgery: vitamin K1
VITAMIN K1 MONITORING IN PREGNANCIES AFTER BARIATRIC SURGERY: A PROSPECTIVE COHORT STUDY
ABSTRACT Background: Neonatal intracranial bleedings and birth defects have been reported, possibly related to maternal vitamin K1 deficiency during pregnancy following bariatric surgery. Objective: To investigate the effects of screening and supplementation on K1 serum levels in pregnant women with bariatric surgery, and to compare K1 levels and prothrombin time (PT %) in the first trimester with pregnant women without bariatric surgery. Setting: One university and 4 peripheral hospitals Methods: A prospective cohort study including 49 pregnant women with bariatric surgery. Nutritional deficiencies were prospectively screened. In case of observed low K1 serum levels, supplementation was provided. K1 serum levels and PT (%) during the first trimester were compared with a non-surgical control group of 27 women. Results: During the first trimester, most women had low K1 serum levels (
