Menopause: The Journal of The North American Menopause Society Vol. 21, No. 11, pp. 1197/1203 DOI: 10.1097/gme.0000000000000238 * 2014 by The North American Menopause Society
Vitamin D levels and menopause-related symptoms Erin S. LeBlanc, MD, MPH,1 Manisha Desai, PhD,2 Nancy Perrin, PhD,1 Jean Wactawski-Wende, PhD,3 JoAnn E. Manson, MD, DrPH,4 Jane A. Cauley, DrPH,5 Yvonne L. Michael, ScD,6 Jean Tang, MD, PhD,7 Catherine Womack, MD,8 Yiqing Song, MD, ScD,9 Karen C. Johnson, MD, MPH,10 Mary J. O’Sullivan, MD,11 Nancy Woods, PhD, RN, FAAN,12 and Marcia L. Stefanick, PhD13 Abstract Objective: This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women. Methods: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women’s Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women’s Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses. Results: Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P’s 9 0.10 for fully adjusted models). Conclusions: There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women. Key Words: Vitamin D Y Menopause Y Hot flashes Y Mood Y Sleep. any women experience menopause-related symptoms long after the final menstrual period. For example, women often experience hot flashes1
Vitamin D levels and menopause-related symptoms Erin S. LeBlanc, MD, MPH,1 Manisha Desai, PhD,2 Nancy Perrin, PhD,1 Jean Wactawski-Wende, PhD,3 JoAnn E. Manson, MD, DrPH,4 Jane A. Cauley, DrPH,5 Yvonne L. Michael, ScD,6 Jean Tang, MD, PhD,7 Catherine Womack, MD,8 Yiqing Song, MD, ScD,9 Karen C. Johnson, MD, MPH,10 Mary J. O’Sullivan, MD,11 Nancy Woods, PhD, RN, FAAN,12 and Marcia L. Stefanick, PhD13 Abstract Objective: This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women. Methods: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women’s Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women’s Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses. Results: Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P’s 9 0.10 for fully adjusted models). Conclusions: There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women. Key Words: Vitamin D Y Menopause Y Hot flashes Y Mood Y Sleep. any women experience menopause-related symptoms long after the final menstrual period. For example, women often experience hot flashes1
