International Journal of
Radiation Oncology biology
physics
www.redjournal.org
Clinical Investigation
Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients Amir Ghorbanzadeh-Moghaddam, MD,* Ali Gholamrezaei, MD,*,y and Simin Hemati, MDz *Medical Student’s Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; yPoursina Hakim Research Institution, Isfahan, Iran; and zDepartment of Radiotherapy Oncology, Isfahan University of Medical Sciences, Isfahan, Iran Received Dec 27, 2014, and in revised form Jan 31, 2015. Accepted for publication Feb 5, 2015.
Summary Vitamin D deficiency may increase susceptibility of the intestinal mucosa to adverse effects of radiation by compromising mucosal barrier and exaggerating inflammatory responses. Association of vitamin D deficiency with the severity of radiation proctitis was investigated in a prospective study of cancer patients undergoing pelvic radiation therapy. Vitamin D deficiency was associated with increased severity of radiation proctitis (grade 2), and this association was independent from possible confounding factors.
Purpose: Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods and Materials: This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of
Radiation Oncology biology
physics
www.redjournal.org
Clinical Investigation
Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients Amir Ghorbanzadeh-Moghaddam, MD,* Ali Gholamrezaei, MD,*,y and Simin Hemati, MDz *Medical Student’s Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; yPoursina Hakim Research Institution, Isfahan, Iran; and zDepartment of Radiotherapy Oncology, Isfahan University of Medical Sciences, Isfahan, Iran Received Dec 27, 2014, and in revised form Jan 31, 2015. Accepted for publication Feb 5, 2015.
Summary Vitamin D deficiency may increase susceptibility of the intestinal mucosa to adverse effects of radiation by compromising mucosal barrier and exaggerating inflammatory responses. Association of vitamin D deficiency with the severity of radiation proctitis was investigated in a prospective study of cancer patients undergoing pelvic radiation therapy. Vitamin D deficiency was associated with increased severity of radiation proctitis (grade 2), and this association was independent from possible confounding factors.
Purpose: Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods and Materials: This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of
