These articles have been accepted for publication in the British Journal of Dermatology and are currently being edited and typeset. Readers should note that articles published below have been fully refereed, but have not been through the copy-editing and proof correction process. Wiley-Blackwell and the British Association of Dermatologists cannot be held responsible for errors or consequences arising from the use of information contained in these articles; nor do the views and opinions expressed necessarily reflect those of Wiley-Blackwell or the British Association of Dermatologists This article is protected by copyright. All rights reserved. Accepted Date : 15-Mar-2014 Article type
: Clinical and laboratory investigations
Vitamin D Deficiency in Alopecia Areata
Running head: Prevalence and associations with disease severity.
A. Aksu Cerman, S. Sarikaya Solak, I. Kivanc Altunay Şişli Etfal Training and Research Hospital, Dermatology Department.
Corresponding author: Aslı Aksu Cerman Şişli Etfal Egitim ve Araştirma Hastanesi, Etfal S., Halaskargazi Cad. 34371 ŞişliIstanbul/Turkey Telephone number: +90 542 619 69 19. Fax: +90 212 224 07 72. E-mail address: [email protected]
This article is protected by copyright. All rights reserved. Conflicts of Interest: No conflict of interest.
What’s already known about this topic? - Alopecia areata is considered a T-cell-mediated autoimmune disease characterized by patchy loss of hair from the scalp and other body parts. - Vitamin D deficiency has been implicated in different autoimmune disorders. What does this study add? - Deficient serum vitamin D levels are present in alopecia areata patients and inversely correlate with disease severity.
Summary Background Alopecia areata is a T-cell mediated autoimmune disease that causes inflammation around anagen-stage hair follicles. Deficient vitamin D levels have been implicated in patients with a variety of autoimmune diseases in recent years. Previous reports have described the effects of vitamin D on hair follicles. Objectives The aim of the study was to evaluate the status of vitamin D in patients with alopecia areata and the relationship between vitamin D levels and disease severity. Methods A cross-sectional study was conducted of 86 patients with alopecia areata, 44 patients with vitiligo, and 58 healthy controls. Serum vitamin D levels of the study group were determined by liquid chromatography/tandem mass spectrometry. Results Serum 25(OH)D levels in patients with alopecia areata were significantly lower than those of the patients with vitiligo and the healthy controls (P= 0.001 and P