RESEARCH ARTICLE
Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus Silvia Savastio1*, Francesco Cadario1,2, Giulia Genoni1, Giorgio Bellomo3, Marco Bagnati3, Gioel Secco4, Raffaella Picchi1, Enza Giglione1, Gianni Bona1 1 Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy, 2 IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Novara, Italy, 3 Central Laboratory of Maggiore della Carità Hospital, University of Piemonte Orientale, Novara, Italy, 4 Division of Cardiology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
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* [email protected]
Abstract OPEN ACCESS Citation: Savastio S, Cadario F, Genoni G, Bellomo G, Bagnati M, Secco G, et al. (2016) Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus. PLoS ONE 11(9): e0162554. doi:10.1371/journal. pone.0162554 Editor: Thomas H. J. Burne, University of Queensland, AUSTRALIA Received: January 5, 2016 Accepted: August 24, 2016 Published: September 8, 2016 Copyright: © 2016 Savastio et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: The paper is part of a project (RF-20102304835) funded by the Ministry of Health. The grant had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist.
Background Vitamin D (25OHD) effects on glycemic control are unclear in children and adolescents with type 1 diabetes. Aims of this study were to investigate 25OHD status among children with T1DM and its relationship with insulin sensitivity and glycemic status.
Subjects and Methods A cross sectional study was carried out between 2008–2014. A total of 141 patients had a T1DM >12 months diagnosis and were enrolled in the present study. Of these 35 (24.8%) were migrants and 106 (75.2%) Italians (T2). We retrospectively analyzed data at the onset of the disease (T0)(64 subjects) and 12–24 months before the last visit (T1,124 subjects). Fasting glucose, glycated hemoglobin (HbA1c), 25OHD levels and daily insulin requirement were evaluated and Cholecalciferol 1000 IU/day supplementation for the management of vitamin D insufficiency (
Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus Silvia Savastio1*, Francesco Cadario1,2, Giulia Genoni1, Giorgio Bellomo3, Marco Bagnati3, Gioel Secco4, Raffaella Picchi1, Enza Giglione1, Gianni Bona1 1 Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy, 2 IRCAD (Interdisciplinary Research Center of Autoimmune Diseases), Novara, Italy, 3 Central Laboratory of Maggiore della Carità Hospital, University of Piemonte Orientale, Novara, Italy, 4 Division of Cardiology, Ospedale Santi Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
a11111
* [email protected]
Abstract OPEN ACCESS Citation: Savastio S, Cadario F, Genoni G, Bellomo G, Bagnati M, Secco G, et al. (2016) Vitamin D Deficiency and Glycemic Status in Children and Adolescents with Type 1 Diabetes Mellitus. PLoS ONE 11(9): e0162554. doi:10.1371/journal. pone.0162554 Editor: Thomas H. J. Burne, University of Queensland, AUSTRALIA Received: January 5, 2016 Accepted: August 24, 2016 Published: September 8, 2016 Copyright: © 2016 Savastio et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper. Funding: The paper is part of a project (RF-20102304835) funded by the Ministry of Health. The grant had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist.
Background Vitamin D (25OHD) effects on glycemic control are unclear in children and adolescents with type 1 diabetes. Aims of this study were to investigate 25OHD status among children with T1DM and its relationship with insulin sensitivity and glycemic status.
Subjects and Methods A cross sectional study was carried out between 2008–2014. A total of 141 patients had a T1DM >12 months diagnosis and were enrolled in the present study. Of these 35 (24.8%) were migrants and 106 (75.2%) Italians (T2). We retrospectively analyzed data at the onset of the disease (T0)(64 subjects) and 12–24 months before the last visit (T1,124 subjects). Fasting glucose, glycated hemoglobin (HbA1c), 25OHD levels and daily insulin requirement were evaluated and Cholecalciferol 1000 IU/day supplementation for the management of vitamin D insufficiency (
