NIH Public Access Author Manuscript Curr HIV/AIDS Rep. Author manuscript; available in PMC 2015 September 01.
NIH-PA Author Manuscript
Published in final edited form as: Curr HIV/AIDS Rep. 2014 September ; 11(3): 263–270. doi:10.1007/s11904-014-0218-8.
Vitamin D Deficiency and Altered Bone Mineral Metabolism in HIV-infected Individuals Allison Ross Eckard, MD1 and Grace A. McComsey, MD2 1Emory 2Case
University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA
Western Reserve University and Rainbow Babies and Children's Hospital, Cleveland, OH
Abstract
NIH-PA Author Manuscript
Although patients with HIV infection are living decades longer than before with the advent of combination antiretroviral therapy, they have an increased rate of co-morbidities associated with chronic HIV, such as osteoporosis, cardiovascular disease, and immune dysfunction. Many of these complications are known to be affected by vitamin D status in the general population. Thus, the high rate of vitamin D deficiency among HIV-infected patients is alarming. Many observational and cohort studies have demonstrated that vitamin D deficiency is associated with these HIV-related complications, but randomized, placebo-controlled trials are limited. This paper reviews recent data on vitamin D deficiency in HIV infection.
Keywords HIV/AIDS; 25-hydroxyvitamin D; vitamin D deficiency; bone; immune system; cardiovascular disease
INTRODUCTION
NIH-PA Author Manuscript
Much attention has been given to the field of vitamin D in HIV-infected patients over the last few years, as research has shown that the prevalence of vitamin D deficiency in the HIV-infected population, as determined by blood concentrations of 25-hydroxyvitamin D (25(OH)D), is very high and widespread. Studies have demonstrated >90% of subjects with HIV have concentrations
NIH-PA Author Manuscript
Published in final edited form as: Curr HIV/AIDS Rep. 2014 September ; 11(3): 263–270. doi:10.1007/s11904-014-0218-8.
Vitamin D Deficiency and Altered Bone Mineral Metabolism in HIV-infected Individuals Allison Ross Eckard, MD1 and Grace A. McComsey, MD2 1Emory 2Case
University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA
Western Reserve University and Rainbow Babies and Children's Hospital, Cleveland, OH
Abstract
NIH-PA Author Manuscript
Although patients with HIV infection are living decades longer than before with the advent of combination antiretroviral therapy, they have an increased rate of co-morbidities associated with chronic HIV, such as osteoporosis, cardiovascular disease, and immune dysfunction. Many of these complications are known to be affected by vitamin D status in the general population. Thus, the high rate of vitamin D deficiency among HIV-infected patients is alarming. Many observational and cohort studies have demonstrated that vitamin D deficiency is associated with these HIV-related complications, but randomized, placebo-controlled trials are limited. This paper reviews recent data on vitamin D deficiency in HIV infection.
Keywords HIV/AIDS; 25-hydroxyvitamin D; vitamin D deficiency; bone; immune system; cardiovascular disease
INTRODUCTION
NIH-PA Author Manuscript
Much attention has been given to the field of vitamin D in HIV-infected patients over the last few years, as research has shown that the prevalence of vitamin D deficiency in the HIV-infected population, as determined by blood concentrations of 25-hydroxyvitamin D (25(OH)D), is very high and widespread. Studies have demonstrated >90% of subjects with HIV have concentrations
