Author's Accepted Manuscript
Vitamin B12 and omega-3 fatty Acids together regulate lipid metabolism in Wistar rats Amrita Khaire, Richa Rathod, Anvita Kale, Sadhana Joshi
www.elsevier.com/locate/plefa
PII: DOI: Reference:
S0952-3278(15)00088-5 http://dx.doi.org/10.1016/j.plefa.2015.04.006 YPLEF1672
To appear in:
Prostaglandins, Leukotrienes and Essential Fatty Acids
Received date: 18 November 2014 Revised date: 7 April 2015 Accepted date: 8 April 2015 Cite this article as: Amrita Khaire, Richa Rathod, Anvita Kale, Sadhana Joshi, Vitamin B12 and omega-3 fatty Acids together regulate lipid metabolism in Wistar rats, Prostaglandins, Leukotrienes and Essential Fatty Acids, http://dx.doi.org/ 10.1016/j.plefa.2015.04.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Vitamin B12 and Omega-3 Fatty Acids Together Regulate Lipid Metabolism in Wistar Rats
Amrita Khaire, Richa Rathod, Anvita Kale, Sadhana Joshi *
*Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed University, Pune Satara Road, Pune 411043, India
*Address for correspondence: Dr. Sadhana Joshi, Scientist "G" Department of Nutritional Medicine, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune Satara Road, Pune 411043, India Tel: (020) 24366929, (020) 24366931 Fax: 020 -24366929 E-mail: [email protected]
Source of Funding: The authors acknowledge the Department of Science and Technology (Govt. of India), New Delhi India for financial support. (Grant no. DST No: SR/SO/HS/59/2010).
Abstract Our recent study indicates that maternal vitamin B12 and omega-3 fatty acid status influence plasma and erythrocyte fatty acid profile in dams. The present study examines the effects of prenatal and postnatal vitamin B12 and omega-3 fatty acid status on lipid metabolism in the offspring. Pregnant dams were divided into five groups: Control; Vitamin B12 deficient (BD); Vitamin B12 supplemented (BS); Vitamin B12 deficient group supplemented with omega-3 fatty acids (BDO); Vitamin B12 supplemented group with omega-3 fatty acids (BSO). The offspring were continued on the same diets till 3 month of age. Vitamin B12 deficiency increased cholesterol levels (p
Vitamin B12 and omega-3 fatty Acids together regulate lipid metabolism in Wistar rats Amrita Khaire, Richa Rathod, Anvita Kale, Sadhana Joshi
www.elsevier.com/locate/plefa
PII: DOI: Reference:
S0952-3278(15)00088-5 http://dx.doi.org/10.1016/j.plefa.2015.04.006 YPLEF1672
To appear in:
Prostaglandins, Leukotrienes and Essential Fatty Acids
Received date: 18 November 2014 Revised date: 7 April 2015 Accepted date: 8 April 2015 Cite this article as: Amrita Khaire, Richa Rathod, Anvita Kale, Sadhana Joshi, Vitamin B12 and omega-3 fatty Acids together regulate lipid metabolism in Wistar rats, Prostaglandins, Leukotrienes and Essential Fatty Acids, http://dx.doi.org/ 10.1016/j.plefa.2015.04.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Vitamin B12 and Omega-3 Fatty Acids Together Regulate Lipid Metabolism in Wistar Rats
Amrita Khaire, Richa Rathod, Anvita Kale, Sadhana Joshi *
*Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth Deemed University, Pune Satara Road, Pune 411043, India
*Address for correspondence: Dr. Sadhana Joshi, Scientist "G" Department of Nutritional Medicine, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune Satara Road, Pune 411043, India Tel: (020) 24366929, (020) 24366931 Fax: 020 -24366929 E-mail: [email protected]
Source of Funding: The authors acknowledge the Department of Science and Technology (Govt. of India), New Delhi India for financial support. (Grant no. DST No: SR/SO/HS/59/2010).
Abstract Our recent study indicates that maternal vitamin B12 and omega-3 fatty acid status influence plasma and erythrocyte fatty acid profile in dams. The present study examines the effects of prenatal and postnatal vitamin B12 and omega-3 fatty acid status on lipid metabolism in the offspring. Pregnant dams were divided into five groups: Control; Vitamin B12 deficient (BD); Vitamin B12 supplemented (BS); Vitamin B12 deficient group supplemented with omega-3 fatty acids (BDO); Vitamin B12 supplemented group with omega-3 fatty acids (BSO). The offspring were continued on the same diets till 3 month of age. Vitamin B12 deficiency increased cholesterol levels (p
