Accepted Manuscript Visual Acuity in Birdshot Retinochoroidopathy Evaluation Sara Touhami, Christine Fardeau, Antoine Vanier, Juliette Knoeri, Claude Simon, Sophie Tezenas du Montcel, Yacine Toumani, Bahram Bodaghi, Phuc LeHoang PII:
S0002-9394(15)00415-8
DOI:
10.1016/j.ajo.2015.07.008
Reference:
AJOPHT 9398
To appear in:
American Journal of Ophthalmology
Received Date: 21 January 2015 Revised Date:
3 July 2015
Accepted Date: 4 July 2015
Please cite this article as: Touhami S, Fardeau C, Vanier A, Knoeri J, Simon C, Tezenas du Montcel S, Toumani Y, Bodaghi B, LeHoang P, Visual Acuity in Birdshot Retinochoroidopathy Evaluation, American Journal of Ophthalmology (2015), doi: 10.1016/j.ajo.2015.07.008. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT AJO 15-84 Abstract:
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Purpose: To determine the statistical correlation between visual acuity (VA) and various quantitative parameters relevant to Birdshot Retinochoroidopathy (BRC) evaluation. Design : Hospital-based retrospective observational study. Methods: Setting : Institutional. Study Population: Consecutive HLA29+ BRC patients were included between May and August 2013 at a single tertiary centre (Pitié-Salpétrière Hospital, Paris). Observation Procedures : Demographic data and quantitative parameters relevant to BRC at baseline were collected: VA, degree of anterior and posterior inflammatory reaction; foveal thickness measured by Optical coherence tomography (OCT), Arden ratio and Electro-oculography (EOG) light peak. Main outcome measures : Correlation between VA and the other parameters of the ipsilateral and fellow eye was performed using Spearman’s rank correlation coefficients. Results: 55 patients were included. Mean VA was 6/9.5 in the right eye (OD) and 6/12 in the left eye (OS). Mean foveal thickness was 240 microns OD (range: 112-606) and 251 microns OS (range: 85-662). Mean Arden ratio was 159% OD and 160% OS. EOG light peak was 714mV OD (range: 316-1379) and 746mV OS (range: 272-1652). VA of a given eye was moderately correlated with VA of the contralateral eye (r = 0.4). On the contrary, all other parameters showed a strong correlation between both eyes (all r>0.7, p 0.8. Statistical analyses were performed using R 3.0.2 (R Development core team, 2013, Vienna, Austria) [15].
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Results: Fifty-five HLA-A29-positive BRC patients were included. Mean disease duration at baseline was 2.8 years (Range: 0.1-24.4 years). Female-to-male sex ratio was 1.6. Demographic and clinical data at baseline are listed in Table 1. At baseline, 2/3 raw number (66.6%) of the patients was naïve of any treatment. Raw number (29%) had previously received oral corticosteroids while only 3/55 (5.5%) had received immunosuppressive treatments (oral Cyclosporin®, intravenous immunoglobulins and oral Mycophenolate Mofetil®, respectively). Mean BCVA was 6/9.5 in the right eye (OD) (Range: 6/126-6/6) and 6/12 in the left eye (OS) (Range: 6/600-6/6). Mean anterior chamber flare values reached 18 photon units/millisecond (ph/ms) OD (Range: 0.1-157 ph/ms) and 23 ph/ms OS (Range: 0.1-373 ph/ms). Most patients had moderate vitreous inflammatory reaction (mean 1.2 +, Range: 0-3). Mean OCT central foveal thickness was 240 microns OD (Range: 112-606 microns) and 251 microns OS (Range: 85-662 microns). Mean Arden ratio was 159% OD (Range: 106-218) and 160% OS (Range: 103-235) while the normal value is >180%. Mean EOG light peak was 714 millivolts OD (Range: 316-1379 millivolts) and 746 millivolts OS (Range: 2721652 millivolts) showing frequent EOG impairment. Table 2 shows the two-by-two correlation coefficients between each pair of parameters. VA did not seem to be significantly correlated to any other parameter of the study (all correlation coefficients
S0002-9394(15)00415-8
DOI:
10.1016/j.ajo.2015.07.008
Reference:
AJOPHT 9398
To appear in:
American Journal of Ophthalmology
Received Date: 21 January 2015 Revised Date:
3 July 2015
Accepted Date: 4 July 2015
Please cite this article as: Touhami S, Fardeau C, Vanier A, Knoeri J, Simon C, Tezenas du Montcel S, Toumani Y, Bodaghi B, LeHoang P, Visual Acuity in Birdshot Retinochoroidopathy Evaluation, American Journal of Ophthalmology (2015), doi: 10.1016/j.ajo.2015.07.008. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
ACCEPTED MANUSCRIPT AJO 15-84 Abstract:
AC C
EP
TE D
M AN U
SC
RI PT
Purpose: To determine the statistical correlation between visual acuity (VA) and various quantitative parameters relevant to Birdshot Retinochoroidopathy (BRC) evaluation. Design : Hospital-based retrospective observational study. Methods: Setting : Institutional. Study Population: Consecutive HLA29+ BRC patients were included between May and August 2013 at a single tertiary centre (Pitié-Salpétrière Hospital, Paris). Observation Procedures : Demographic data and quantitative parameters relevant to BRC at baseline were collected: VA, degree of anterior and posterior inflammatory reaction; foveal thickness measured by Optical coherence tomography (OCT), Arden ratio and Electro-oculography (EOG) light peak. Main outcome measures : Correlation between VA and the other parameters of the ipsilateral and fellow eye was performed using Spearman’s rank correlation coefficients. Results: 55 patients were included. Mean VA was 6/9.5 in the right eye (OD) and 6/12 in the left eye (OS). Mean foveal thickness was 240 microns OD (range: 112-606) and 251 microns OS (range: 85-662). Mean Arden ratio was 159% OD and 160% OS. EOG light peak was 714mV OD (range: 316-1379) and 746mV OS (range: 272-1652). VA of a given eye was moderately correlated with VA of the contralateral eye (r = 0.4). On the contrary, all other parameters showed a strong correlation between both eyes (all r>0.7, p 0.8. Statistical analyses were performed using R 3.0.2 (R Development core team, 2013, Vienna, Austria) [15].
AC C
EP
TE D
Results: Fifty-five HLA-A29-positive BRC patients were included. Mean disease duration at baseline was 2.8 years (Range: 0.1-24.4 years). Female-to-male sex ratio was 1.6. Demographic and clinical data at baseline are listed in Table 1. At baseline, 2/3 raw number (66.6%) of the patients was naïve of any treatment. Raw number (29%) had previously received oral corticosteroids while only 3/55 (5.5%) had received immunosuppressive treatments (oral Cyclosporin®, intravenous immunoglobulins and oral Mycophenolate Mofetil®, respectively). Mean BCVA was 6/9.5 in the right eye (OD) (Range: 6/126-6/6) and 6/12 in the left eye (OS) (Range: 6/600-6/6). Mean anterior chamber flare values reached 18 photon units/millisecond (ph/ms) OD (Range: 0.1-157 ph/ms) and 23 ph/ms OS (Range: 0.1-373 ph/ms). Most patients had moderate vitreous inflammatory reaction (mean 1.2 +, Range: 0-3). Mean OCT central foveal thickness was 240 microns OD (Range: 112-606 microns) and 251 microns OS (Range: 85-662 microns). Mean Arden ratio was 159% OD (Range: 106-218) and 160% OS (Range: 103-235) while the normal value is >180%. Mean EOG light peak was 714 millivolts OD (Range: 316-1379 millivolts) and 746 millivolts OS (Range: 2721652 millivolts) showing frequent EOG impairment. Table 2 shows the two-by-two correlation coefficients between each pair of parameters. VA did not seem to be significantly correlated to any other parameter of the study (all correlation coefficients
