Pediatr Nephrol (2014) 29:757–766 DOI 10.1007/s00467-014-2761-3
REVIEW
Vesicoureteric reflux and reflux nephropathy: from mouse models to childhood disease Marie-Lyne Fillion & Christine L. Watt & Indra R. Gupta
Received: 27 September 2013 / Revised: 30 December 2013 / Accepted: 8 January 2014 / Published online: 6 February 2014 # IPNA 2014
Abstract Vesicoureteric reflux (VUR) is a common congenital urinary tract defect that predisposes children to recurrent kidney infections. Kidney infections can result in renal scarring or reflux nephropathy defined by the presence of chronic tubulo-interstitial inflammation and fibrosis that is a frequent cause of end-stage renal failure. The discovery of mouse models with VUR and with reflux nephropathy has provided new opportunities to understand the pathogenesis of these conditions and may provide insight on the genes and the associated phenotypes that need to be examined in human studies. Keywords Vesicoureteric reflux . Mouse models . Reflux nephropathy . Children
Introduction Congenital abnormalities of the kidney and urinary tract, or CAKUT, constitute a spectrum of kidney and urinary tract disorders, the most common of which is vesicoureteric reflux (VUR). VUR is a urinary tract defect in which an abnormal uretero-vesical junction (UVJ) promotes the retrograde flow of urine from the bladder to the kidneys. VUR has been M.
REVIEW
Vesicoureteric reflux and reflux nephropathy: from mouse models to childhood disease Marie-Lyne Fillion & Christine L. Watt & Indra R. Gupta
Received: 27 September 2013 / Revised: 30 December 2013 / Accepted: 8 January 2014 / Published online: 6 February 2014 # IPNA 2014
Abstract Vesicoureteric reflux (VUR) is a common congenital urinary tract defect that predisposes children to recurrent kidney infections. Kidney infections can result in renal scarring or reflux nephropathy defined by the presence of chronic tubulo-interstitial inflammation and fibrosis that is a frequent cause of end-stage renal failure. The discovery of mouse models with VUR and with reflux nephropathy has provided new opportunities to understand the pathogenesis of these conditions and may provide insight on the genes and the associated phenotypes that need to be examined in human studies. Keywords Vesicoureteric reflux . Mouse models . Reflux nephropathy . Children
Introduction Congenital abnormalities of the kidney and urinary tract, or CAKUT, constitute a spectrum of kidney and urinary tract disorders, the most common of which is vesicoureteric reflux (VUR). VUR is a urinary tract defect in which an abnormal uretero-vesical junction (UVJ) promotes the retrograde flow of urine from the bladder to the kidneys. VUR has been M.
