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ANESTHESIAAND ANALGESIA. Current Researches VOL.54, No. 6, Nov.-DEc.,1975

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Venous Air Embolism Prophylaxis with a Surface-Active Agent JOEL C. PERRY, M.D." EDWIN S. MUNSON, M.D.7 MARJORIE H. MALAGODI, Ph.D.$ DINESH 0. SHAH, Ph.D.S Gainesville, Florida 11

The protective effect of a nonionic surfaceactive polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studied in 21 dogs anesthetized with pentobarbital. Aortic, pulmonary artery and right ventricular pressures, cardiac output, end-tidal CO, concentration, wasted ventilation, and blood surface tensions were measured be-

fore and after the IV administration of this surfactant. The magnitudes of change in the cardiorespiratory responses measured after venous air embolism were significantly (p

Venous air embolism prophylaxis with a surface-active agent.

The protective effect of a nonionic surface-active polyol agent (Pluronic F-68) against bolus injection and constant-rate IV infusion of air was studi...
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