Gut and Liver, Vol. 9, No. 5, September 2015, pp. 629-635
ORiginal Article
Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer Yoon Sung Bae*, Hoguen Kim*, Sung Hoon Noh†, and Hyunki Kim* Departments of *Pathology and †Surgery, Yonsei University College of Medicine, Seoul, Korea
Background/Aims: The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated. Methods: The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI-H) and 261 microsatellitestable (MSS) advanced gastric cancers (AGCs) were compared. Next, we compared the immunohistochemistry results for hMLH1 and hMSH2 with those of a polymerase chain reaction (PCR)-based method. Kaplan-Meier curves and a Cox proportional hazard regression model were used to conduct survival analyses. Results: The MSI-H AGCs were correlated with older age (p
ORiginal Article
Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer Yoon Sung Bae*, Hoguen Kim*, Sung Hoon Noh†, and Hyunki Kim* Departments of *Pathology and †Surgery, Yonsei University College of Medicine, Seoul, Korea
Background/Aims: The usefulness of immunohistochemistry to screen for the microsatellite instability (MSI) phenotype in gastric cancer remains unclear. Moreover, the prognostic value of MSI phenotypes in gastric cancer has been debated. Methods: The clinicopathologic parameters and survival outcomes of 203 MSI-high (MSI-H) and 261 microsatellitestable (MSS) advanced gastric cancers (AGCs) were compared. Next, we compared the immunohistochemistry results for hMLH1 and hMSH2 with those of a polymerase chain reaction (PCR)-based method. Kaplan-Meier curves and a Cox proportional hazard regression model were used to conduct survival analyses. Results: The MSI-H AGCs were correlated with older age (p
