Scand J Urol Nephrol26: 351-355, 1992
USE OF INDOMETHACIN IN THE PROPHYLAXIS OF URETERAL COLIC FOLLOWING EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY Yen-Chuan Ou, Thomas I-Sheng Hwang, Chi-Rei Yang, Chi-Lung Chang, Chao-Hsiang Chang and Hsi-Chin Wu From the Section of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
Scand J Urol Nephrol Downloaded from informahealthcare.com by McMaster University on 11/05/14 For personal use only.
(Submitted August 19, 1991. Accepted for publication December 13, 1991)
Abstract. Ureteral obstruction leading to pain seems to be related to an increase of renal prostaglandins (PG). We designed a prospective double-blind, placebo controlled protocol for evaluating the effect of indomethacin, a PG-synthetase inhibitor, in the prophylaxis of ureteral colic following extracorporeal shock wave lithotripsy (ESWL). Sixty patients undergoing ESWL were randomized into two groups, group 1 (study group) received 50 mg indomethacin capsule three times daily and group 2 (control group) received multiple-vitamin tablet three times daily. Twentyfour hours urine samples were collected before and three days afier ESWL was performed for PGEZ (predominant renal PG) determination. Subjective pain after ESWL was recorded with pain score (0-10 degrees). Oral codein or pethidine injection were available for relieving pain following ESWL. The pain score, analgesic requirement and urinary PGEZ in pre- and post-ESWL were used to compare the two groups. Thc pain score was 4.00k0.25 and 3.00 -t0.25 in the control and study groups respectively; it had a statistically significant difference (P