Nutrition, Metabolism & Cardiovascular Diseases (2014) xx, 1e6

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Uric acid levels and the risk of Contrast Induced Nephropathy in patients undergoing coronary angiography or PCI L. Barbieri a, M. Verdoia a, A. Schaffer a, E. Cassetti a, P. Marino a, H. Suryapranata b, G. De Luca a,*, on behalf of the Novara Atherosclerosis Study Group (NAS) a b

Division of Cardiology, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Eastern Piedmont University, Novara, Italy Department of Cardiology, UMC St Radboud, HS, Nijmegen, The Netherlands

Received 30 March 2014; received in revised form 30 July 2014; accepted 21 August 2014 Available online - - -

KEYWORDS Contrast Induced Nephropathy; Hyperuricemia; Coronary angiography; Percutaneous interventions

Abstract Background and aim: Contrast Induced Nephropathy (CIN) is a common complication of procedures that require the use of contrast media, and seems to be mediated by oxidative stress and reactive oxygen species generation. Hyperuricemia is characterized by inhibited nitric oxide system and enhanced synthesis of reactive oxygen species. However, few studies have so far investigated the association between hyperuricemia and CIN that is therefore the aim of the current study among patients undergoing coronary angiography or percutaneous intervention. Methods and results: We analyzed a total of 1950 patients with Creatinine clearance 140 mm Hg and/or diastolic pressure >90 mm Hg or if the individual was taking antihypertensive medications. All patients with creatinine clearance