Department of Anesthesioiogty, &mama&u Medicine, Hamamatsu, Shizuoka, Japan.

Study

Objective:

enflurane, Design:

Prospective

man subjects. Setting: Inpatient elective

pkar*macokinetic

The patients

othane, enflwane,

isoflurane,

being

[equivalent

investigated

halothane,

0.85%;

enflurane,

in, inspired concentrations

*Assistant Professor

for GO minutes.

iProfessor

concentrations

Measurements separately

Address reprint reqrreses to Dr. Shiraishi at rhe Department of Anesthesiology, Namamatsu Universnty School of Medicine, 3600 Handa-cho, Japan.

Mamamatsu,

Shizucka,

43 1-3 1

Received. for pubiicarion September 29, 1989; revised manuscript accepted for pubLication January 25, 1990.

during minute.

un&hetic

study of sevojlurane medical

were assigned

for

a.d?~~~istratio~~ in hucenter.

One of the four

to I. I minimum 1.85%;

throughout

alveolm

undergoing

minor

The

(MAC):

of

concentrations

The cumulative inhalation

serum and urinary fluoride of all gases

uptake gfeach

were

measured

a~estk,etic agent

of tke uptake rate per

of sevqflurane (1. I MAC} showed an

bod3 .ytirface area and MAC) rate of 3.3%.

;lioi”atiEeanesthetics

ccnzentration

isoflurane, I .27%; and sev@urune, 1.88%; the first hour anestkesia,l arias administered

was calculated as an integration

The results for one-hour

mated degradation

haloihane,

to one of ,four g~oujx: hal-

randomly

or sevoflurane.

with a mass spectrometer.

uptake (corrected

w&

in humans.

genera-al anesthesia.

and Main Results: In all patients,

period

of

sevo@

Uptake and biotransformation of sevoflurane in humans: a comparative study of sevoflurane with halothane, enflurane, and isoflurane.

To compare the volatile anesthetic sevoflurane with halothane, enflurane, and isoflurane on the uptake and biotransformation in humans...
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