Department of Anesthesioiogty, &mama&u Medicine, Hamamatsu, Shizuoka, Japan.
Study
Objective:
enflurane, Design:
Prospective
man subjects. Setting: Inpatient elective
pkar*macokinetic
The patients
othane, enflwane,
isoflurane,
being
[equivalent
investigated
halothane,
0.85%;
enflurane,
in, inspired concentrations
*Assistant Professor
for GO minutes.
iProfessor
concentrations
Measurements separately
Address reprint reqrreses to Dr. Shiraishi at rhe Department of Anesthesiology, Namamatsu Universnty School of Medicine, 3600 Handa-cho, Japan.
Mamamatsu,
Shizucka,
43 1-3 1
Received. for pubiicarion September 29, 1989; revised manuscript accepted for pubLication January 25, 1990.
during minute.
un&hetic
study of sevojlurane medical
were assigned
for
a.d?~~~istratio~~ in hucenter.
One of the four
to I. I minimum 1.85%;
throughout
alveolm
undergoing
minor
The
(MAC):
of
concentrations
The cumulative inhalation
serum and urinary fluoride of all gases
uptake gfeach
were
measured
a~estk,etic agent
of tke uptake rate per
of sevqflurane (1. I MAC} showed an
bod3 .ytirface area and MAC) rate of 3.3%.
;lioi”atiEeanesthetics
ccnzentration
isoflurane, I .27%; and sev@urune, 1.88%; the first hour anestkesia,l arias administered
was calculated as an integration
The results for one-hour
mated degradation
haloihane,
to one of ,four g~oujx: hal-
randomly
or sevoflurane.
with a mass spectrometer.
uptake (corrected
w&
in humans.
genera-al anesthesia.
and Main Results: In all patients,
period
of
sevo@