Int Urol Nephrol (2014) 46:2243–2249 DOI 10.1007/s11255-014-0831-x
UROLOGY - ORIGINAL PAPER
Upper and lower urinary tract infections can be detected early but not be discriminated by urinary NGAL in adults Anja Urbschat · Nicholas Obermüller · Patrick Paulus · Manuel Reissig · Peyman Hadji · Rainer Hofmann · Helmut Geiger · Stefan Gauer
Received: 10 April 2014 / Accepted: 27 August 2014 / Published online: 14 September 2014 © Springer Science+Business Media Dordrecht 2014
Abstract Purpose We investigated whether the recently established biomarkers of acute kidney injury, neutrophil gelatinaseassociated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1), may help to diagnose acute urinary tract infections (UTI) in adults and are able to distinguish between upper or lower localization. Methods NGAL levels were measured in blood and urine, and KIM-1 concentrations in urine of 97 subjects. We recruited age- and gender-matched groups of 30 patients with acute upper UTI and 29 patients with acute lower UTI as well as 38 healthy controls. NGAL and KIM-1 were determined by ELISA, serum and urine creatinine applying the Jaffé’s method.
A. Urbschat (*) Faculty of Medicine, Philipps-University Marburg, Baldinger Strasse, 35043 Marburg, Germany e-mail: [email protected]‑marburg.de N. Obermüller · M. Reissig · H. Geiger · S. Gauer Clinic of Internal Medicine III, Division of Nephrology, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany P. Paulus Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany P. Hadji Clinic of Gynecology and Reproductive Medicine, University Hospital Marburg, Philipps-University, Marburg, Germany R. Hofmann Clinic of Urology and Pediatric Urology, University Hospital Marburg, Philipps-University, Marburg, Germany
Results Urinary NGAL (uNGAL) was significantly increased in patients with upper as well as with lower UTI compared with the healthy controls (P
UROLOGY - ORIGINAL PAPER
Upper and lower urinary tract infections can be detected early but not be discriminated by urinary NGAL in adults Anja Urbschat · Nicholas Obermüller · Patrick Paulus · Manuel Reissig · Peyman Hadji · Rainer Hofmann · Helmut Geiger · Stefan Gauer
Received: 10 April 2014 / Accepted: 27 August 2014 / Published online: 14 September 2014 © Springer Science+Business Media Dordrecht 2014
Abstract Purpose We investigated whether the recently established biomarkers of acute kidney injury, neutrophil gelatinaseassociated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1), may help to diagnose acute urinary tract infections (UTI) in adults and are able to distinguish between upper or lower localization. Methods NGAL levels were measured in blood and urine, and KIM-1 concentrations in urine of 97 subjects. We recruited age- and gender-matched groups of 30 patients with acute upper UTI and 29 patients with acute lower UTI as well as 38 healthy controls. NGAL and KIM-1 were determined by ELISA, serum and urine creatinine applying the Jaffé’s method.
A. Urbschat (*) Faculty of Medicine, Philipps-University Marburg, Baldinger Strasse, 35043 Marburg, Germany e-mail: [email protected]‑marburg.de N. Obermüller · M. Reissig · H. Geiger · S. Gauer Clinic of Internal Medicine III, Division of Nephrology, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany P. Paulus Clinic of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University, Frankfurt am Main, Germany P. Hadji Clinic of Gynecology and Reproductive Medicine, University Hospital Marburg, Philipps-University, Marburg, Germany R. Hofmann Clinic of Urology and Pediatric Urology, University Hospital Marburg, Philipps-University, Marburg, Germany
Results Urinary NGAL (uNGAL) was significantly increased in patients with upper as well as with lower UTI compared with the healthy controls (P
