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Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature Diagnostic Pathology 2014, 9:8
doi:10.1186/1746-1596-9-8
Shi-gang Wu ([email protected]) Yang Li ([email protected]) Bin Li ([email protected]) Xiao-ying Tian ([email protected]) Zhi Li ([email protected])
ISSN Article type
1746-1596 Case Report
Submission date
11 December 2013
Acceptance date
31 December 2013
Publication date
20 January 2014
Article URL
http://www.diagnosticpathology.org/content/9/1/8
This peer-reviewed article can be downloaded, printed and distributed freely for any purposes (see copyright notice below). Articles in Diagnostic Pathology are listed in PubMed and archived at PubMed Central. For information about publishing your research in Diagnostic Pathology or any BioMed Central journal, go to http://www.diagnosticpathology.org/authors/instructions/ For information about other BioMed Central publications go to http://www.biomedcentral.com/
© 2014 Wu et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature Shi-gang Wu1,2 Email: [email protected] Yang Li1 Email: [email protected] Bin Li1 Email: [email protected] Xiao-ying Tian3 Email: [email protected] Zhi Li1* * Corresponding author Email: [email protected] 1
Department of Pathology, The First Affiliated Hospital, Sun Yat-sen university, 58, Zhongshan Road II, Guangzhou 510080, China 2
Department of Pathology, Qingyuan People’s Hospital B24, Yinquan Road, Qingcheng District, Qingyuan City 511518, China 3
School of Chinese Medicine, Hong Kong Baptist University. 7, Baptist University Road, Kowloon Tong, Hong Kong, China
Abstract Background In rare condition, combined thymic epithelial tumors showing either type A or type B thymomas areas combined with thymic carcinoma components may occur in thymus. Mucoepidermoid carcinoma (MEC) of the thymus is rare in thymic carcinoma, and so far there is no report to describe a combined epithelial tumor of thymus with MEC component. We report an unusual case of combined thymic MEC/type B2 thymoma in a middle-aged male occurring in a mass of anterior mediastinum. Case report: A 51-year-old Chinese male patient presented with a 6-month history of right ptosis and progressive muscle weakness. Computed tomography (CT) examination revealed a solitary, well-circumscribed mass was in the anterior mediastinum with mild heterogeneous enhancement. Histologically, the mass contained two separated components and displayed typically histological features of lowgrade MEC and type B2 thymoma, respectively. There was no gradual transition of these two components observed in mass, and no enlarged lymph node was found in the surrounding tissues. A diagnosis of combined thymic MEC/type B2 thymoma was made. The patient received thymectomy to resect the mass totally. After surgery, chemotherapy with regiments
of cisplatin and mitomycin, and radiotherapy of the main tumor bed were performed on the patient. There was no evidence of tumor recurrence during the period of 12 months followup.
Conclusion To our best knowledge, this is the first report of combined thymic epithelial tumor with MEC component. Although this tumor is rare, the diagnosis of a thymic MEC should be taken into consideration when a combined epithelial tumor is occasionally encountered in thymus.
Virtual slides The virtual slide(s) for this article can be http://www.diagnosticpathology.diagnomx.eu/vs/9721397571157894
found
here:
Keywords Thymic neoplasm, Combined thymic epithelial tumor, Mucoepidermoid carcinoma, Thymoma, Differential diagnosis
Background Primary thymic carcinoma is a rare tumor of the anterior mediastinum. Mucoepidermoid carcinoma (MEC) of the thymus is rare in thymic caircinoma, and comprises approximately 2% of published thymic carcinoma [1,2]. Up to date, no more than 30 cases of thymic MEC have been described in the literature [3-15]. In rare condition, combined thymic epithelial tumors showing either type A or type B thymomas areas combined with thymic carcinoma components may occur primarily in thymus, and are exceptionally rare (
Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature Diagnostic Pathology 2014, 9:8
doi:10.1186/1746-1596-9-8
Shi-gang Wu ([email protected]) Yang Li ([email protected]) Bin Li ([email protected]) Xiao-ying Tian ([email protected]) Zhi Li ([email protected])
ISSN Article type
1746-1596 Case Report
Submission date
11 December 2013
Acceptance date
31 December 2013
Publication date
20 January 2014
Article URL
http://www.diagnosticpathology.org/content/9/1/8
This peer-reviewed article can be downloaded, printed and distributed freely for any purposes (see copyright notice below). Articles in Diagnostic Pathology are listed in PubMed and archived at PubMed Central. For information about publishing your research in Diagnostic Pathology or any BioMed Central journal, go to http://www.diagnosticpathology.org/authors/instructions/ For information about other BioMed Central publications go to http://www.biomedcentral.com/
© 2014 Wu et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature Shi-gang Wu1,2 Email: [email protected] Yang Li1 Email: [email protected] Bin Li1 Email: [email protected] Xiao-ying Tian3 Email: [email protected] Zhi Li1* * Corresponding author Email: [email protected] 1
Department of Pathology, The First Affiliated Hospital, Sun Yat-sen university, 58, Zhongshan Road II, Guangzhou 510080, China 2
Department of Pathology, Qingyuan People’s Hospital B24, Yinquan Road, Qingcheng District, Qingyuan City 511518, China 3
School of Chinese Medicine, Hong Kong Baptist University. 7, Baptist University Road, Kowloon Tong, Hong Kong, China
Abstract Background In rare condition, combined thymic epithelial tumors showing either type A or type B thymomas areas combined with thymic carcinoma components may occur in thymus. Mucoepidermoid carcinoma (MEC) of the thymus is rare in thymic carcinoma, and so far there is no report to describe a combined epithelial tumor of thymus with MEC component. We report an unusual case of combined thymic MEC/type B2 thymoma in a middle-aged male occurring in a mass of anterior mediastinum. Case report: A 51-year-old Chinese male patient presented with a 6-month history of right ptosis and progressive muscle weakness. Computed tomography (CT) examination revealed a solitary, well-circumscribed mass was in the anterior mediastinum with mild heterogeneous enhancement. Histologically, the mass contained two separated components and displayed typically histological features of lowgrade MEC and type B2 thymoma, respectively. There was no gradual transition of these two components observed in mass, and no enlarged lymph node was found in the surrounding tissues. A diagnosis of combined thymic MEC/type B2 thymoma was made. The patient received thymectomy to resect the mass totally. After surgery, chemotherapy with regiments
of cisplatin and mitomycin, and radiotherapy of the main tumor bed were performed on the patient. There was no evidence of tumor recurrence during the period of 12 months followup.
Conclusion To our best knowledge, this is the first report of combined thymic epithelial tumor with MEC component. Although this tumor is rare, the diagnosis of a thymic MEC should be taken into consideration when a combined epithelial tumor is occasionally encountered in thymus.
Virtual slides The virtual slide(s) for this article can be http://www.diagnosticpathology.diagnomx.eu/vs/9721397571157894
found
here:
Keywords Thymic neoplasm, Combined thymic epithelial tumor, Mucoepidermoid carcinoma, Thymoma, Differential diagnosis
Background Primary thymic carcinoma is a rare tumor of the anterior mediastinum. Mucoepidermoid carcinoma (MEC) of the thymus is rare in thymic caircinoma, and comprises approximately 2% of published thymic carcinoma [1,2]. Up to date, no more than 30 cases of thymic MEC have been described in the literature [3-15]. In rare condition, combined thymic epithelial tumors showing either type A or type B thymomas areas combined with thymic carcinoma components may occur primarily in thymus, and are exceptionally rare (
