Original Article
Arthritis Care & Research DOI 10.1002/acr.22346
U.S. adults meeting 2010 American College of Rheumatology criteria for treatment and prevention of glucocorticoid-induced osteoporosis
Robert A. Overman, MPH1,2, Joshua C. Toliver, BA3, Jun-Yen Yeh, PhD4, Margaret L. Gourlay, MD, MPH5, Chad L. Deal, MD2
1
Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy,
University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Orthopedic and Rheumatologic Institute, Department of Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, 3UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 4 Division of Social & Administrative Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, 5Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
Corresponding Author: Robert A. Overman, MPH University of North Carolina at Chapel Hill Eshelman School of Pharmacy Division of Pharmaceutical Outcomes and Policy Campus Box 7579 Chapel Hill, NC 27599-7579 Phone: 614-570-8041 Fax: 919-966-7557 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an ‘Accepted Article’, doi: 10.1002/acr.22346 © 2014 American College of Rheumatology Received: Sep 04, 2013; Revised: Feb 11, 2014; Accepted: Apr 01, 2014
Arthritis Care & Research
Page 2 of 31
Proportion of US adults meeting 2010 ACR GIO guidelines Email: [email protected]
No Conflicts of Interest No Financial Support
Word Count: 4077
Keywords: American College of Rheumatology Criteria, Glucocorticoid-induced Osteoporosis, Glucocorticoids, Epidemiology, Osteoporosis
2 John Wiley & Sons, Inc.
Page 3 of 31
Arthritis Care & Research
Proportion of US adults meeting 2010 ACR GIO guidelines Abstract: Background/Purpose: The American College of Rheumatology (ACR) updated its guidelines on the prevention and treatment of glucocorticoid-induced osteoporosis (GIO) in 2010. An unknown proportion of US adults at risk for fracture due to glucocorticoid use would be recommended anti-osteoporosis pharmaceutical (AOP) therapies based on the ACR guidelines. Methods: Using the 2005-2010 National Health and Nutrition Examination Survey (NHANES) data for postmenopausal women (PMW) and men aged ≥50 years reporting current glucocorticoid use, we categorized individuals according to ACR criteria for low, medium and high fracture risk (
Arthritis Care & Research DOI 10.1002/acr.22346
U.S. adults meeting 2010 American College of Rheumatology criteria for treatment and prevention of glucocorticoid-induced osteoporosis
Robert A. Overman, MPH1,2, Joshua C. Toliver, BA3, Jun-Yen Yeh, PhD4, Margaret L. Gourlay, MD, MPH5, Chad L. Deal, MD2
1
Division of Pharmaceutical Outcomes and Policy, UNC Eshelman School of Pharmacy,
University of North Carolina at Chapel Hill, Chapel Hill, NC, 2Orthopedic and Rheumatologic Institute, Department of Rheumatology, Cleveland Clinic Foundation, Cleveland, OH, 3UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 4 Division of Social & Administrative Sciences, Arnold & Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY, 5Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
Corresponding Author: Robert A. Overman, MPH University of North Carolina at Chapel Hill Eshelman School of Pharmacy Division of Pharmaceutical Outcomes and Policy Campus Box 7579 Chapel Hill, NC 27599-7579 Phone: 614-570-8041 Fax: 919-966-7557 This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as an ‘Accepted Article’, doi: 10.1002/acr.22346 © 2014 American College of Rheumatology Received: Sep 04, 2013; Revised: Feb 11, 2014; Accepted: Apr 01, 2014
Arthritis Care & Research
Page 2 of 31
Proportion of US adults meeting 2010 ACR GIO guidelines Email: [email protected]
No Conflicts of Interest No Financial Support
Word Count: 4077
Keywords: American College of Rheumatology Criteria, Glucocorticoid-induced Osteoporosis, Glucocorticoids, Epidemiology, Osteoporosis
2 John Wiley & Sons, Inc.
Page 3 of 31
Arthritis Care & Research
Proportion of US adults meeting 2010 ACR GIO guidelines Abstract: Background/Purpose: The American College of Rheumatology (ACR) updated its guidelines on the prevention and treatment of glucocorticoid-induced osteoporosis (GIO) in 2010. An unknown proportion of US adults at risk for fracture due to glucocorticoid use would be recommended anti-osteoporosis pharmaceutical (AOP) therapies based on the ACR guidelines. Methods: Using the 2005-2010 National Health and Nutrition Examination Survey (NHANES) data for postmenopausal women (PMW) and men aged ≥50 years reporting current glucocorticoid use, we categorized individuals according to ACR criteria for low, medium and high fracture risk (
