Medicine

®

OBSERVATIONAL STUDY

Type 1 Diabetes and Increased Risk of Subsequent Asthma A Nationwide Population-Based Cohort Study Yung-Tsung Hsiao, MD, Wen-Chien Cheng, MD, Wei-Chih Liao, MD, Cheng-Li Lin, MSc, Te-Chun Shen, MD, Wei-Chun Chen, MD, Chia-Hung Chen, MD, and Chia-Hung Kao, MD

Abstract: The association between type 1 diabetes mellitus (T1DM) and asthma remains controversial and has led to new interest in these 2 disorders. The purpose of this study was to examine the associations among young people with T1DM and asthma and offer a clinical demonstration of the balance between Th1 and Th2 responses. We conducted a retrospective cohort study by using data from the National Health Insurance (NHI) system of Taiwan. The cohort consisted of 3545 T1DM cases and 14,180 controls established during the 1998 to 2011 period. Of the 3545 T1DM patients, 55.1% were girls and 26.5% were in the age group 8  Age, mean  SD y Urbanization 1 (highest) 2 3 4 (lowest) Parental occupation White collar Blue collar Others

T1DM (N ¼ 3545) n (%)

P value 0.99

7816 (55.1) 6364 (44.9)

1954 (55.1) 1591 (44.9)

2953 (20.8) 11,227 (79.2) 12.4 (5.10)

940 (26.5) 2605 (73.5) 11.3 (5.04)

38,150 4266 2791 3308

1000 1111 660 774