J Gastrointest Surg (2014) 18:1284–1291 DOI 10.1007/s11605-014-2533-1
ORIGINAL ARTICLE
Tumor Size Predicts Vascular Invasion and Histologic Grade Among Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma Gaya Spolverato & Aslam Ejaz & Yuhree Kim & Georgios C. Sotiropoulos & Andreas Pau & Sorin Alexandrescu & Hugo Marques & Carlo Pulitano & Eduardo Barroso & Bryan M. Clary & Luca Aldrighetti & Todd W. Bauer & Dustin M. Walters & Ryan Groeschl & T. Clark Gamblin & Wallis Marsh & Kevin T. Nguyen & Ryan Turley & Irinel Popescu & Catherine Hubert & Stephanie Meyer & Jean-Francois Gigot & Gilles Mentha & Timothy M. Pawlik
Received: 30 March 2014 / Accepted: 1 May 2014 / Published online: 20 May 2014 # 2014 The Society for Surgery of the Alimentary Tract
Abstract The association between tumor size and survival in patients with intrahepatic cholangiocarcinoma (ICC) undergoing surgical resection is controversial. We sought to define the incidence of major and microscopic vascular invasion relative to ICC tumor size, and identify predictors of microscopic vascular invasion in patients with ICC ≥5 cm. A total of 443 patients undergoing surgical resection for ICC between 1973 and 2011 at one of 11 participating institutions were identified. Clinical and pathologic data were evaluated using uni- and multivariate analyses. As tumor sized increased, the incidence of microscopic vascular invasion increased:
ORIGINAL ARTICLE
Tumor Size Predicts Vascular Invasion and Histologic Grade Among Patients Undergoing Resection of Intrahepatic Cholangiocarcinoma Gaya Spolverato & Aslam Ejaz & Yuhree Kim & Georgios C. Sotiropoulos & Andreas Pau & Sorin Alexandrescu & Hugo Marques & Carlo Pulitano & Eduardo Barroso & Bryan M. Clary & Luca Aldrighetti & Todd W. Bauer & Dustin M. Walters & Ryan Groeschl & T. Clark Gamblin & Wallis Marsh & Kevin T. Nguyen & Ryan Turley & Irinel Popescu & Catherine Hubert & Stephanie Meyer & Jean-Francois Gigot & Gilles Mentha & Timothy M. Pawlik
Received: 30 March 2014 / Accepted: 1 May 2014 / Published online: 20 May 2014 # 2014 The Society for Surgery of the Alimentary Tract
Abstract The association between tumor size and survival in patients with intrahepatic cholangiocarcinoma (ICC) undergoing surgical resection is controversial. We sought to define the incidence of major and microscopic vascular invasion relative to ICC tumor size, and identify predictors of microscopic vascular invasion in patients with ICC ≥5 cm. A total of 443 patients undergoing surgical resection for ICC between 1973 and 2011 at one of 11 participating institutions were identified. Clinical and pathologic data were evaluated using uni- and multivariate analyses. As tumor sized increased, the incidence of microscopic vascular invasion increased:
