IDCases 10 (2017) 60
Contents lists available at ScienceDirect
IDCases journal homepage: www.elsevier.com/locate/idcases
Case illustrated
Trypanosoma cruzi, organ transplant related a,⁎
a
MARK a
a
Ana Belén Latzke , Pehuén Fernández , Carlos Chiurchiu , Jorge Luis De la Fuente , Sebastián Calivab, Florencia Boniscontic, Juan Pablo Caeirod a Department of Nephrology and Kidney Transplantation, Hospital Privado Universitario de Córdoba, Universidad Católica de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Fundación Nefrológica de Córdoba, Argentina b Department of Microbiology, Hospital Privado Universitario de Córdoba, Argentina c Department of Histocompatibility, Hospital Privado Universitario de Córdoba, Argentina d Department of Infectology, Hospital Privado Universitario de Córdoba, Argentina
A 53-year-old man had received a cadaver-donor renal transplant from a donor with positive serology for Chagas disease. The patient had received high-dose immunosuppressive therapy due to two episodes of early acute renal allograft rejection. Three months after transplantation, he presented with unexplained fever. Multiple Trypanosoma cruzi parasites were found in a peripheral blood smear (photo and video), and a parasite load (by real-time PCR) above one million parasites per milliliter of blood was detected. Both benznidazole and itraconazole were prescribed for one year. The patient showed good clinical response after treatment and parasites disappeared from blood. Chagas disease is an endemic zoonosis in South America, which is caused by the parasite Trypanosoma cruzi and generally transmitted by stings and contaminated defecation of triatomine bugs. Transmission through transplanted solid organs from infected donors constitutes another well-recognized mechanism of transmission. Images of clinical medicine
Appendix A. Supplementary data Supplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.idcr.2017.09.001.
⁎
Corresponding author. E-mail address: [email protected] (A.B. Latzke).
http://dx.doi.org/10.1016/j.idcr.2017.09.001 Received 1 September 2017; Accepted 1 September 2017 2214-2509/ © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Contents lists available at ScienceDirect
IDCases journal homepage: www.elsevier.com/locate/idcases
Case illustrated
Trypanosoma cruzi, organ transplant related a,⁎
a
MARK a
a
Ana Belén Latzke , Pehuén Fernández , Carlos Chiurchiu , Jorge Luis De la Fuente , Sebastián Calivab, Florencia Boniscontic, Juan Pablo Caeirod a Department of Nephrology and Kidney Transplantation, Hospital Privado Universitario de Córdoba, Universidad Católica de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Fundación Nefrológica de Córdoba, Argentina b Department of Microbiology, Hospital Privado Universitario de Córdoba, Argentina c Department of Histocompatibility, Hospital Privado Universitario de Córdoba, Argentina d Department of Infectology, Hospital Privado Universitario de Córdoba, Argentina
A 53-year-old man had received a cadaver-donor renal transplant from a donor with positive serology for Chagas disease. The patient had received high-dose immunosuppressive therapy due to two episodes of early acute renal allograft rejection. Three months after transplantation, he presented with unexplained fever. Multiple Trypanosoma cruzi parasites were found in a peripheral blood smear (photo and video), and a parasite load (by real-time PCR) above one million parasites per milliliter of blood was detected. Both benznidazole and itraconazole were prescribed for one year. The patient showed good clinical response after treatment and parasites disappeared from blood. Chagas disease is an endemic zoonosis in South America, which is caused by the parasite Trypanosoma cruzi and generally transmitted by stings and contaminated defecation of triatomine bugs. Transmission through transplanted solid organs from infected donors constitutes another well-recognized mechanism of transmission. Images of clinical medicine
Appendix A. Supplementary data Supplementary data associated with this article can be found, in the online version, at http://dx.doi.org/10.1016/j.idcr.2017.09.001.
⁎
Corresponding author. E-mail address: [email protected] (A.B. Latzke).
http://dx.doi.org/10.1016/j.idcr.2017.09.001 Received 1 September 2017; Accepted 1 September 2017 2214-2509/ © 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
