Trends in Pulmonary Valve Replacement in Children and Adults With Tetralogy of Fallot Michael L. O’Byrne, MD, MSCEa,b,c,*, Andrew C. Glatz, MD, MSCEa,b,c, Laura Mercer-Rosa, MD, MSCEa,b,c, Matthew J. Gillespie, MDa,b, Yoav Dori, MD, PhDa,b, Elizabeth Goldmuntz, MDa,b, Steven Kawut, MD, MSc,d, and Jonathan J. Rome, MDa,b Operative correction of tetralogy of Fallot frequently results in pulmonary insufficiency and chronic volume overload, which have been linked to increased risk for adverse outcomes. No consensus recommendations for the timing of pulmonary valve replacement (PVR) exist. The aim of this study was to examine the pattern of PVR in the United States from 2004 to 2012. The Pediatric Health Information Systems database was used to perform an observational study of children and adults ‡10 years of age with diagnoses of tetralogy of Fallot who underwent PVR at 35 centers in the United States from 2004 and 2012, to assess the rate of PVR and the age at which is performed. Mixed-effects multivariate regression was used to account for patient-level covariates and center-level covariance. Additional analyses assessed for trends in cost, hospital length of stay (LOS), intensive care unit LOS, and in-hospital mortality over the study period. In total, 799 subjects at 35 centers underwent PVR over the study period. The number of PVRs performed per year increased significantly over the study period. There was significant between-center heterogeneity in age at PVR (p

Trends in pulmonary valve replacement in children and adults with tetralogy of fallot.

Operative correction of tetralogy of Fallot frequently results in pulmonary insufficiency and chronic volume overload, which have been linked to incre...
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