© 1991 S. Karger AG, Basel 1015-2008/91/0594-0264S2.75/0
Macrophage: 1990 Annu Conf Upper Rhine Univ (II) Pathobiology 1991;59:264-267
Treatment of Cancer Patients with Endotoxin Induces Release of Endogenous Cytokines Andreas Mackensen*, Chris Galanosb, Rupert Engelhardt* d e p a rtm e n t of Hematology and Oncology, Albert Ludwigs University, and bMax-Planck-Institute for Immunobiology, Freiburg, FRG
Key Words. Lipopolysaccharide • Endogenous cytokines ■Cancer patients Abstract. This study sought to determine whether endogenous tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and granulocyte-colony-stimulating factor (G-CSF) were detectable in sera of lipopolysaccharide (LPS)-treated cancer patients. Twenty patients received an intravenous bolus of purified LPS from Salmonella abortus equi (4.0 ng/kg). Patients were pretreated with ibuprofen (1,600 mg) to prevent constitutional side effects like fever and chills. Serum TNF-a levels increased from
Macrophage: 1990 Annu Conf Upper Rhine Univ (II) Pathobiology 1991;59:264-267
Treatment of Cancer Patients with Endotoxin Induces Release of Endogenous Cytokines Andreas Mackensen*, Chris Galanosb, Rupert Engelhardt* d e p a rtm e n t of Hematology and Oncology, Albert Ludwigs University, and bMax-Planck-Institute for Immunobiology, Freiburg, FRG
Key Words. Lipopolysaccharide • Endogenous cytokines ■Cancer patients Abstract. This study sought to determine whether endogenous tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) and granulocyte-colony-stimulating factor (G-CSF) were detectable in sera of lipopolysaccharide (LPS)-treated cancer patients. Twenty patients received an intravenous bolus of purified LPS from Salmonella abortus equi (4.0 ng/kg). Patients were pretreated with ibuprofen (1,600 mg) to prevent constitutional side effects like fever and chills. Serum TNF-a levels increased from
