RESEARCH ARTICLE
Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues Radka Gromnicova1, Mehmet Kaya2, Ignacio A. Romero1, Phil Williams3, Simon Satchell4, Basil Sharrack5, David Male1* 1 Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, United Kingdom, 2 Department of Physiology, Koc University School of Medicine, Istanbul, Turkey, 3 Midatech Pharma plc, Abingdon, United Kingdom, 4 School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, 5 Department of Neurology, University of Sheffield, Sheffield, United Kingdom * [email protected]
a11111
Abstract
OPEN ACCESS Citation: Gromnicova R, Kaya M, Romero IA, Williams P, Satchell S, Sharrack B, et al. (2016) Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues. PLoS ONE 11(8): e0161610. doi:10.1371/journal. pone.0161610 Editor: V. Prasad Shastri, University of Freiburg, GERMANY Received: April 12, 2016 Accepted: August 9, 2016 Published: August 25, 2016 Copyright: © 2016 Gromnicova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by Sheffield Teaching Hospitals Trust and the Biotechnology and Biological Sciences Research Council (BB/K009184/ 1). The funders provided support in the form of salaries for authors (RG, IAR) and consumables, but did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Midatech Pharma plc provided nanoparticles and facilities for ICP mass
The selective entry of nanoparticles into target tissues is the key factor which determines their tissue distribution. Entry is primarily controlled by microvascular endothelial cells, which have tissue-specific properties. This study investigated the cellular properties involved in selective transport of gold nanoparticles (
Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues Radka Gromnicova1, Mehmet Kaya2, Ignacio A. Romero1, Phil Williams3, Simon Satchell4, Basil Sharrack5, David Male1* 1 Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, United Kingdom, 2 Department of Physiology, Koc University School of Medicine, Istanbul, Turkey, 3 Midatech Pharma plc, Abingdon, United Kingdom, 4 School of Clinical Sciences, University of Bristol, Bristol, United Kingdom, 5 Department of Neurology, University of Sheffield, Sheffield, United Kingdom * [email protected]
a11111
Abstract
OPEN ACCESS Citation: Gromnicova R, Kaya M, Romero IA, Williams P, Satchell S, Sharrack B, et al. (2016) Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues. PLoS ONE 11(8): e0161610. doi:10.1371/journal. pone.0161610 Editor: V. Prasad Shastri, University of Freiburg, GERMANY Received: April 12, 2016 Accepted: August 9, 2016 Published: August 25, 2016 Copyright: © 2016 Gromnicova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information files. Funding: This work was supported by Sheffield Teaching Hospitals Trust and the Biotechnology and Biological Sciences Research Council (BB/K009184/ 1). The funders provided support in the form of salaries for authors (RG, IAR) and consumables, but did not have any role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Midatech Pharma plc provided nanoparticles and facilities for ICP mass
The selective entry of nanoparticles into target tissues is the key factor which determines their tissue distribution. Entry is primarily controlled by microvascular endothelial cells, which have tissue-specific properties. This study investigated the cellular properties involved in selective transport of gold nanoparticles (
