Iranian Journal of Pharmaceutical Research (2013), 12 (4): 579
Copyright © 2013 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services
Editorial
Transgenic Animals in Pharmaceutical and Biological Research in Iran Mehrdad Faizi
Meehrdad Faizi Transgenic (Tg) mice are very important models of disease, and have been introduced to biological studies since Transgen 1982. They used for in understanding the pathobiology of different diseases, in finding nicareAnimals Pharmacceutical and d Biological Research n Iran targets for pharmacological manipulations, and for the evaluation of efficacy and toxicity of medicines in preclinical studies. Many different types of Tg mice are available as models for human diseases. For examples, there are Tg mice for different types of cancers, Down syndrome, Alzheimer’s disease, mice are verryheart and Transsgenic (Tg) important t models of disease, d have osteoporosis, been introduced tto Huntington›s disease, diabetes mellitus, disease, hypertension, epilepsy, obesity, bioloblindness, es since 198 82. They arand re used for understand of gical studie glaucoma, deafness, anxiety, depression, many other diseases. ding the patthobiology o differrentanimals disease es,used finding targets for pharmacol logical mannipulations, and for thhe Transgenic are in toxicity assessments as well. There are several Tg animal models for mutagenicity approvedand by the like lacZTgl mice for evaluation evalu uationassays of effficacy toxicity t World Health of medicines m Organization inn preclinical studies. M Many differennt of mutagenicity of medicines. Tg-rasH2 is another Tg model sensitive Fo toorboth genotoxic and are T typess of Tg micee are availabl le mouse as models s for human diseases. examples , there Tg non-genotoxic carcinogens and is used in pharmaceutical industries as a substitute method to evaluate mice for differen nt types of cancers, c Dow wn syndrom me, Alzheimeer’s disease, Huntingtonn's the carcinogenicity of novel compounds. disea ase, diabetes s mellitus, heart h disease e, hypertens sion, epilepssy, obesity, osteoporosis, In recent years the global attention to biotechnological products has been dramatically increased. glauccoma, blindn deafnes anxiety,recombinant depression, d aand many oth diseases . of Transgenic animals canness, also be used ss, to produce proteins.There areher many examples such applications for Tg animals. Productions of tissue plasminogen activator and recombinant human Transsgenic alscases are used in Tg toxicity assessments a in the biotechasindustries. well. The ere are sever ral Tg animaal antithrombin III in anima goat are of using animals Production of Factors VIII and IX C in cows,assa or ays developing sheep and Factor XIII, and lacZT mode elsand forprotein mutag genicity approved d bymilk theincludes Woorldthrombin Health O Organization n like Tg alpha-1-antitrypsin, or expression of malaria protein in mice for vaccine development are important mice for evaluatiion of mutag genicity of medicines. m T Tg-rasH2 moouse is anothher Tg modeel examples for this kind of application. sensittive to both genotoxic and a non-geno otoxic carcinnogens and iis used in phharmaceuticaal The ethical concerns about the genetic modifications of animals are very important issues and have indusstries as a substitute meth hod to evalu uate the carciinogenicity oof novel com mpounds. been closely debated in many scientific discussions. In the last decade the contribution of Iranians in science production and their technological In recentespecially years the t in global to biotechnolog b sciences, have gicalbeen produc cts has been n dramaticallly achievements, medicalatttention and biological considerably increased. ased. Transg genic anima als can also be used to produce rec combinant pproteins.Ther re incre Therefore, demanding a greater consideration for genetically modified animals. Several strains of Tg mice available in many countries. access .to Productio these animals many m commercially exam mples of su uch applicat tionsHowever, for T Tgtheanimals. ns for of tissuue are are pharmaceutical researchers is very limited at this time in Iran. This requires serious attention from plasm minogen activator and reecombinant human h antithhrombin III in goat are ccases of usinng decision in the medical researches in Iran in order for this be solved. Tg makers an nimals in the e biotech ind dustries. Pro oduction ofproblem F Factorsto VIII I and Commercially IX andd protein C iin available Tg animals can be provided either by domestic or international private companies and will cows, or develo oping sheep p milk inclu udes thrombbin and Faactor XIII, and alpha-11be a great service for scientists and researchers in Iran.
antitrrypsin, or expression e of o malaria protein in mice for vvaccine deveelopment arre important examp les for this kind k of ication. Mehrdad Faizi is currently working as appli Associate Professor and Head of Department of
Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, be reached the genetic followingmodifications [email protected] faizi64@ TheIran. ethical e He could conce erns aboutatth he me-mail address: s of animals are veryorimp portant issuees yahoo.com and have h been clo osely debateed in many sccientific disccussions.
In th he last deccade the co ontribution of Iranianss in sciencce productioon and theeir techn nological ach hievements, especially in medical and biologiical sciencees, have beeen consiiderably inccreased. Theerefore, dem manding a ggreater conssideration foor geneticallly modified animalls. Several strains of Tg T mice arre commerccially availaable in manny counttries. Howev ver, the access to these animals forr pharmaceuutical researrchers is verry
Copyright © 2013 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services
Editorial
Transgenic Animals in Pharmaceutical and Biological Research in Iran Mehrdad Faizi
Meehrdad Faizi Transgenic (Tg) mice are very important models of disease, and have been introduced to biological studies since Transgen 1982. They used for in understanding the pathobiology of different diseases, in finding nicareAnimals Pharmacceutical and d Biological Research n Iran targets for pharmacological manipulations, and for the evaluation of efficacy and toxicity of medicines in preclinical studies. Many different types of Tg mice are available as models for human diseases. For examples, there are Tg mice for different types of cancers, Down syndrome, Alzheimer’s disease, mice are verryheart and Transsgenic (Tg) important t models of disease, d have osteoporosis, been introduced tto Huntington›s disease, diabetes mellitus, disease, hypertension, epilepsy, obesity, bioloblindness, es since 198 82. They arand re used for understand of gical studie glaucoma, deafness, anxiety, depression, many other diseases. ding the patthobiology o differrentanimals disease es,used finding targets for pharmacol logical mannipulations, and for thhe Transgenic are in toxicity assessments as well. There are several Tg animal models for mutagenicity approvedand by the like lacZTgl mice for evaluation evalu uationassays of effficacy toxicity t World Health of medicines m Organization inn preclinical studies. M Many differennt of mutagenicity of medicines. Tg-rasH2 is another Tg model sensitive Fo toorboth genotoxic and are T typess of Tg micee are availabl le mouse as models s for human diseases. examples , there Tg non-genotoxic carcinogens and is used in pharmaceutical industries as a substitute method to evaluate mice for differen nt types of cancers, c Dow wn syndrom me, Alzheimeer’s disease, Huntingtonn's the carcinogenicity of novel compounds. disea ase, diabetes s mellitus, heart h disease e, hypertens sion, epilepssy, obesity, osteoporosis, In recent years the global attention to biotechnological products has been dramatically increased. glauccoma, blindn deafnes anxiety,recombinant depression, d aand many oth diseases . of Transgenic animals canness, also be used ss, to produce proteins.There areher many examples such applications for Tg animals. Productions of tissue plasminogen activator and recombinant human Transsgenic alscases are used in Tg toxicity assessments a in the biotechasindustries. well. The ere are sever ral Tg animaal antithrombin III in anima goat are of using animals Production of Factors VIII and IX C in cows,assa or ays developing sheep and Factor XIII, and lacZT mode elsand forprotein mutag genicity approved d bymilk theincludes Woorldthrombin Health O Organization n like Tg alpha-1-antitrypsin, or expression of malaria protein in mice for vaccine development are important mice for evaluatiion of mutag genicity of medicines. m T Tg-rasH2 moouse is anothher Tg modeel examples for this kind of application. sensittive to both genotoxic and a non-geno otoxic carcinnogens and iis used in phharmaceuticaal The ethical concerns about the genetic modifications of animals are very important issues and have indusstries as a substitute meth hod to evalu uate the carciinogenicity oof novel com mpounds. been closely debated in many scientific discussions. In the last decade the contribution of Iranians in science production and their technological In recentespecially years the t in global to biotechnolog b sciences, have gicalbeen produc cts has been n dramaticallly achievements, medicalatttention and biological considerably increased. ased. Transg genic anima als can also be used to produce rec combinant pproteins.Ther re incre Therefore, demanding a greater consideration for genetically modified animals. Several strains of Tg mice available in many countries. access .to Productio these animals many m commercially exam mples of su uch applicat tionsHowever, for T Tgtheanimals. ns for of tissuue are are pharmaceutical researchers is very limited at this time in Iran. This requires serious attention from plasm minogen activator and reecombinant human h antithhrombin III in goat are ccases of usinng decision in the medical researches in Iran in order for this be solved. Tg makers an nimals in the e biotech ind dustries. Pro oduction ofproblem F Factorsto VIII I and Commercially IX andd protein C iin available Tg animals can be provided either by domestic or international private companies and will cows, or develo oping sheep p milk inclu udes thrombbin and Faactor XIII, and alpha-11be a great service for scientists and researchers in Iran.
antitrrypsin, or expression e of o malaria protein in mice for vvaccine deveelopment arre important examp les for this kind k of ication. Mehrdad Faizi is currently working as appli Associate Professor and Head of Department of
Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, be reached the genetic followingmodifications [email protected] faizi64@ TheIran. ethical e He could conce erns aboutatth he me-mail address: s of animals are veryorimp portant issuees yahoo.com and have h been clo osely debateed in many sccientific disccussions.
In th he last deccade the co ontribution of Iranianss in sciencce productioon and theeir techn nological ach hievements, especially in medical and biologiical sciencees, have beeen consiiderably inccreased. Theerefore, dem manding a ggreater conssideration foor geneticallly modified animalls. Several strains of Tg T mice arre commerccially availaable in manny counttries. Howev ver, the access to these animals forr pharmaceuutical researrchers is verry
