INVITED COMMENTARIES Primum Non Nocere Carlo Agostoni See ‘‘Safety of a New Amino Acid Formula in Infants Allergic to Cow’s Milk and Intolerant to Hydrolysates’’ by Dupont et al on page 456.

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mino acid–based formulas are elemental mixtures and should be recommended for children with cow’s-milk allergy (CMA) failing to respond to extensively hydrolyzed formulas. In spite of their relatively long-lasting availability, questions related to safety, either clinical or nutritional, have been debated for a long while. In this issue of the Journal of Pediatric Gastroenterology and Nutrition, Dupont et al (1) describe the effects of a new amino acid formula, containing also a pectin-based thickener, and a reference amino acid formula on allergy symptoms and safety, evaluated through blood biochemistry analysis (at inclusion and 3 months) and growth. Infants ages

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