LAB/IN VITRO RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2017; 23: 4192-4204 DOI: 10.12659/MSM.903500

TRAF2 is a Valuable Prognostic Biomarker in Patients with Prostate Cancer

Received: 2017.01.23 Accepted: 2017.02.26 Published: 2017.08.31

Authors’ Contribution: Study Design  A Data Collection  B Statistical Analysis  C Data Interpretation  D Manuscript Preparation  E Literature Search  F Funds Collection  G

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Bingbing Wei* Jiabei Liang* Jimeng Hu* Yuanyuan Mi* Jun Ruan Jian Zhang Zhirong Wang Qiang Hu Haowen Jiang Qiang Ding

1 Department of Urology, Huashan Hospital, Fudan University, Shanghai, P.R. China 2 Department of Pathology, Affiliated Wuxi People’s Hospital, Nanjing Medical University, Wuxi, Jiangsu, P.R. China 3 Department of Urology, Affiliated Wuxi People’s Hospital, Nanjing Medical University, Wuxi, Jiangsu, P.R. China

Corresponding Authors: Source of support:

* These authors contributed equally to the writing of this article Qiang Ding, e-mail: [email protected], Haowen Jiang, e-mail: [email protected], Qiang Hu, e-mail: [email protected] The work was funded by grants from the Research Program of the Wuxi Health and Family Planning Commission (Q201612), the Key Program of Hospital Management Center, China (YGZX1112), and the Foundation of Nanjing Medical University, China (2013NJMU157)



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TRAF2 exerts important functions in regulating the development and progression of cancer. The aim of this study is to investigate whether TRAF2 is a valuable prognostic biomarker and to determine if it regulates TRAILinduced apoptosis in prostate cancer. Microarray gene expression data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were used to determine TRAF2 expression in prostate cancer. TRAF2 expression in prostate cancer was further investigated by immunohistochemistry assay. Kaplan–Meier curves and log-rank test were used to assess the recurrence-free rate. Cox regression was used to analyze prognostic factors. Effects of TRAF2 on regulating TRAIL-induced apoptosis in DU-145 cells were further investigated. We found that TRAF2 was significantly upregulated in prostate cancer compared with normal prostate samples (P

TRAF2 is a Valuable Prognostic Biomarker in Patients with Prostate Cancer.

BACKGROUND TRAF2 exerts important functions in regulating the development and progression of cancer. The aim of this study is to investigate whether T...
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