Europe PMC Funders Group Author Manuscript Am J Clin Nutr. Author manuscript; available in PMC 2016 May 01. Published in final edited form as: Am J Clin Nutr. 2015 November ; 102(5): 1081–1087. doi:10.3945/ajcn.115.115295.
Europe PMC Funders Author Manuscripts
Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation Rebecca J. Moon1,2, Sarah R. Crozier1, Elaine M. Dennison1, Justin H. Davies2, Sian M. Robinson1, Hazel M. Inskip1, Keith M. Godfrey1,3, Cyrus Cooper1,3,4,*, and Nicholas C. Harvey1,3,* 1MRC
Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD
2Paediatric
Endocrinology, University Hospitals Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD
3NIHR
Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK, SO16 6YD
4NIHR
Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, OX3 7LD
Abstract
Europe PMC Funders Author Manuscripts
Background—The role of maternal 25-hydroxyvitamin D [25(OH)D] in fetal development is uncertain and findings of observational studies are inconsistent. Most studies have assessed 25(OH)D only once in pregnancy, but the tracking of an individual’s 25(OH)D during pregnancy is unknown. Objective—We determined the tracking of serum 25(OH)D from early to late pregnancy, and factors which influence this. Design—The Southampton Women’s Survey is a prospective mother-offspring birth cohort study. Lifestyle, diet and 25(OH)D status were assessed at 11 and 34 weeks gestation. A Fourier transformation was used to model seasonal variation in 25(OH)D for early and late pregnancy, separately, and the difference between measured and seasonally modelled 25(OH)D calculated to generate a season-corrected 25(OH)D. Tracking was assessed using Pearson’s correlation coefficient, and multivariate linear regression used to determine factors associated with change in season-corrected 25(OH)D.
Corresponding Author and person to whom reprint requests should be addressed: Professor Cyrus Cooper, Director and Professor of Rheumatology, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton.SO16 6YD, Tel: 023 8077 7624; Fax: 023 8070 4021, [email protected]. *joint senior author Author contributions to the manuscript SMR, HMI, KMG and CC conceived, designed and conducted the SWS. RJM, NCH and CC conceived this sub-study. RJM and SRC performed the statistical analysis. RJM and NCH wrote the paper with contributions from all authors. CC has primary responsibility for the final content. All authors have read and approved the final manuscript. Disclosures KMG has acted as a consultant to Abbott Nutrition and Nestle Nutrition, and has received reimbursement for speaking at an Abbott Nutrition Conference on Pregnancy Nutrition and Later Health Outcomes, at a Nestle Nutrition Institute Workshop and at a workshop funded by the International Life Sciences Institute (ILSI Europe). He is part of an academic consortium that has received research funding from Abbott Nutrition, Nestec and Danone. No other authors declare a conflict of interest.
Moon et al.
Page 2
Europe PMC Funders Author Manuscripts
Results—1753 women had 25(OH)D measured in both early and late pregnancy. There was a moderate correlation between season-corrected 25(OH)D measurements at 11 and 34 weeks gestation (r=0.53, p
Europe PMC Funders Author Manuscripts
Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation Rebecca J. Moon1,2, Sarah R. Crozier1, Elaine M. Dennison1, Justin H. Davies2, Sian M. Robinson1, Hazel M. Inskip1, Keith M. Godfrey1,3, Cyrus Cooper1,3,4,*, and Nicholas C. Harvey1,3,* 1MRC
Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD
2Paediatric
Endocrinology, University Hospitals Southampton NHS Foundation Trust, Tremona Road, Southampton, SO16 6YD
3NIHR
Southampton Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK, SO16 6YD
4NIHR
Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, OX3 7LD
Abstract
Europe PMC Funders Author Manuscripts
Background—The role of maternal 25-hydroxyvitamin D [25(OH)D] in fetal development is uncertain and findings of observational studies are inconsistent. Most studies have assessed 25(OH)D only once in pregnancy, but the tracking of an individual’s 25(OH)D during pregnancy is unknown. Objective—We determined the tracking of serum 25(OH)D from early to late pregnancy, and factors which influence this. Design—The Southampton Women’s Survey is a prospective mother-offspring birth cohort study. Lifestyle, diet and 25(OH)D status were assessed at 11 and 34 weeks gestation. A Fourier transformation was used to model seasonal variation in 25(OH)D for early and late pregnancy, separately, and the difference between measured and seasonally modelled 25(OH)D calculated to generate a season-corrected 25(OH)D. Tracking was assessed using Pearson’s correlation coefficient, and multivariate linear regression used to determine factors associated with change in season-corrected 25(OH)D.
Corresponding Author and person to whom reprint requests should be addressed: Professor Cyrus Cooper, Director and Professor of Rheumatology, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton.SO16 6YD, Tel: 023 8077 7624; Fax: 023 8070 4021, [email protected]. *joint senior author Author contributions to the manuscript SMR, HMI, KMG and CC conceived, designed and conducted the SWS. RJM, NCH and CC conceived this sub-study. RJM and SRC performed the statistical analysis. RJM and NCH wrote the paper with contributions from all authors. CC has primary responsibility for the final content. All authors have read and approved the final manuscript. Disclosures KMG has acted as a consultant to Abbott Nutrition and Nestle Nutrition, and has received reimbursement for speaking at an Abbott Nutrition Conference on Pregnancy Nutrition and Later Health Outcomes, at a Nestle Nutrition Institute Workshop and at a workshop funded by the International Life Sciences Institute (ILSI Europe). He is part of an academic consortium that has received research funding from Abbott Nutrition, Nestec and Danone. No other authors declare a conflict of interest.
Moon et al.
Page 2
Europe PMC Funders Author Manuscripts
Results—1753 women had 25(OH)D measured in both early and late pregnancy. There was a moderate correlation between season-corrected 25(OH)D measurements at 11 and 34 weeks gestation (r=0.53, p
