Multiplehttp://msj.sagepub.com/ Sclerosis Journal
Tracking changes over time in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in multiple sclerosis Divya Narayanan, Han Cheng, Karlie N Bonem, Roberto Saenz, Rosa A Tang and Laura J Frishman Mult Scler published online 17 March 2014 DOI: 10.1177/1352458514523498 The online version of this article can be found at: http://msj.sagepub.com/content/early/2014/03/13/1352458514523498
Published by: http://www.sagepublications.com
On behalf of: European Committee for Treatment and Research in Multiple Sclerosis
Americas Committee for Treatment and Research in Multiple Sclerosis
Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
Latin American Committee on Treatment and Research of Multiple Sclerosis
Additional services and information for Multiple Sclerosis Journal can be found at: Email Alerts: http://msj.sagepub.com/cgi/alerts Subscriptions: http://msj.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav Downloaded from msj.sagepub.com at ANADOLU UNIV on May 8, 2014
>> OnlineFirst Version of Record - Mar 17, 2014 What is This?
Downloaded from msj.sagepub.com at ANADOLU UNIV on May 8, 2014
523498 research-article2014
MSJ0010.1177/1352458514523498Multiple Sclerosis JournalNarayanan et al.
MULTIPLE SCLEROSIS MSJ JOURNAL
Research Paper
Tracking changes over time in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in multiple sclerosis
Multiple Sclerosis Journal 1–11 © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1352458514523498 msj.sagepub.com
Divya Narayanan1, Han Cheng1, Karlie N Bonem1, Roberto Saenz1, Rosa A Tang2 and Laura J Frishman1
Abstract Background: Neurodegeneration plays an important role in permanent disability in multiple sclerosis (MS). Objective: The objective of this paper is to determine whether progressive neurodegeneration occurs in MS eyes without clinically evident inflammation. Methods: Retinal nerve fiver layer thickness (RNFLT) and ganglion cell-inner plexiform layer thickness (GCIPT) were measured using Cirrus optical coherence tomography (OCT) in 133 relapsing–remitting MS (RRMS) patients (149 nonoptic neuritis (ON), 97 ON eyes, last ON ≥6 months). Ninety-three patients were scanned at two visits. Percentages of abnormal GCIPT vs RNFLT (
Tracking changes over time in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in multiple sclerosis Divya Narayanan, Han Cheng, Karlie N Bonem, Roberto Saenz, Rosa A Tang and Laura J Frishman Mult Scler published online 17 March 2014 DOI: 10.1177/1352458514523498 The online version of this article can be found at: http://msj.sagepub.com/content/early/2014/03/13/1352458514523498
Published by: http://www.sagepublications.com
On behalf of: European Committee for Treatment and Research in Multiple Sclerosis
Americas Committee for Treatment and Research in Multiple Sclerosis
Pan-Asian Committee for Treatment and Research in Multiple Sclerosis
Latin American Committee on Treatment and Research of Multiple Sclerosis
Additional services and information for Multiple Sclerosis Journal can be found at: Email Alerts: http://msj.sagepub.com/cgi/alerts Subscriptions: http://msj.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav Downloaded from msj.sagepub.com at ANADOLU UNIV on May 8, 2014
>> OnlineFirst Version of Record - Mar 17, 2014 What is This?
Downloaded from msj.sagepub.com at ANADOLU UNIV on May 8, 2014
523498 research-article2014
MSJ0010.1177/1352458514523498Multiple Sclerosis JournalNarayanan et al.
MULTIPLE SCLEROSIS MSJ JOURNAL
Research Paper
Tracking changes over time in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in multiple sclerosis
Multiple Sclerosis Journal 1–11 © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1352458514523498 msj.sagepub.com
Divya Narayanan1, Han Cheng1, Karlie N Bonem1, Roberto Saenz1, Rosa A Tang2 and Laura J Frishman1
Abstract Background: Neurodegeneration plays an important role in permanent disability in multiple sclerosis (MS). Objective: The objective of this paper is to determine whether progressive neurodegeneration occurs in MS eyes without clinically evident inflammation. Methods: Retinal nerve fiver layer thickness (RNFLT) and ganglion cell-inner plexiform layer thickness (GCIPT) were measured using Cirrus optical coherence tomography (OCT) in 133 relapsing–remitting MS (RRMS) patients (149 nonoptic neuritis (ON), 97 ON eyes, last ON ≥6 months). Ninety-three patients were scanned at two visits. Percentages of abnormal GCIPT vs RNFLT (
