Original Article

EAJM 2011; 43: 79-82

Trace Element Levels in Patients with Familial Mediterranean Fever FMF Hastalarında Eser Element Düzeyleri Kadir Yildirim1, Hulya Uzkeser1, Abdullah Uyanik2, Saliha Karatay1, Ahmet Kiziltunc3 Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ataturk University, Erzurum, Turkey Department of Nephrology, Faculty of Medicine, Ataturk University, Erzurum, Turkey 3 Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey 1 2

Abstract

Özet

Objective: Although the genetic etiology of familial Mediterranean fever (FMF) is known, limited information is available regarding the regulation of inflammation during attack-free periods. The aim of this study was to determine the alterations in serum copper (Cu), zinc (Zn) and selenium (Se) levels that may be associated with inflammation during attack-free periods in FMF patients.

Amaç: Ailesel Akdeniz ateşi (FMF) hastalığının genetik etiyolojisi bilinmesine rağmen, ataksız dönemdeki inflamasyonun düzenlenişi hakkındaki bilgiler sınırlıdır. Bu çalışmanın amacı, FMF hastalığının ataksız döneminde inflamasyonla ilişkili olabilecek serum bakır (Cu), çinko (Zn) ve selenyum (Se) seviyelerindeki değişimleri değerlendirmektir.

Materials and Methods: This study included 33 patients with FMF and 30 healthy volunteers. Erythrocyte sedimentation rate (ESR), the serum C-reactive protein (CRP) level and serum levels of Cu, Zn and Se in FMF patients and healthy volunteers were assessed by the atomic absorption spectrophotometry method.

Gereç ve Yöntem: Bu çalışma 33 FMF hastası ve 30 sağlıklı gönüllüyle düzenlendi. FMF hastalarındaki eritrosit sedimentasyon hızı (ESH), serum C reaktif protein (CRP), Cu, Zn ve Se düzeyleri atomik absorbsiyon spektrofotometri metoduyla değerlendirildi.

Results: ESR and serum CRP levels and serum Cu and Zn levels were similar between patients with FMF during an attack-free period and healthy controls (p>0.05). Serum Se levels in the patient group were significantly higher than in the control group (p0.05). Hasta grubunda serum Se düzeyleri kontrol grubundan anlamlı derecede daha yüksekti (p0.05). The serum Se levels in the FMF patients in an attackfree period were significantly higher than in the healthy controls (p

Trace element levels in patients with familial mediterranean Fever.

Ailesel Akdeniz ateşi (FMF) hastalığının genetik etiyolojisi bilinmesine rağmen, ataksız dönemdeki inflamasyonun düzenlenişi hakkındaki bilgiler sınır...
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