RESEARCH ARTICLE
Total-body CT and MR features of postmortem change in in-hospital deaths Ivo M. Wagensveld1,2*, Britt M. Blokker1,2, Piotr A. Wielopolski1, Nomdo S. Renken3, Gabriel P. Krestin1, Myriam G. Hunink1,4, J. Wolter Oosterhuis2, Annick C. Weustink1,2 1 Department of Radiology and Nuclear Medicine, Erasmus University Medical Centre, Rotterdam, ZuidHolland, The Netherlands, 2 Department of Pathology, Erasmus University Medical Centre, Rotterdam, ZuidHolland, The Netherlands, 3 Department of Radiology, Reinier de Graaf Gasthuis, Delft, Zuid-Holland, The Netherlands, 4 Centre for Health Decision Science, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America
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* [email protected]
Abstract Objectives
OPEN ACCESS Citation: Wagensveld IM, Blokker BM, Wielopolski PA, Renken NS, Krestin GP, Hunink MG, et al. (2017) Total-body CT and MR features of postmortem change in in-hospital deaths. PLoS ONE 12(9): e0185115. https://doi.org/10.1371/ journal.pone.0185115 Editor: Andrew Churg, University of British Columbia, CANADA Received: June 15, 2017 Accepted: September 5, 2017 Published: September 27, 2017 Copyright: © 2017 Wagensveld et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information file. Funding: The following funders supported this work: Erasmus MC health care efficiency, 201010112; Stichting Coolsingel (NL), 255; Erasmus MC vriendenfonds, 104117. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
To evaluate the frequency of total-body CT and MR features of postmortem change in inhospital deaths.
Materials and methods In this prospective blinded cross-sectional study, in-hospital deceased adult patients underwent total-body postmortem CT and MR followed by image-guided biopsies. The presence of PMCT and PMMR features related to postmortem change was scored retrospectively and correlated with postmortem time interval, post-resuscitation status and intensive care unit (ICU) admittance.
Results Intravascular air, pleural effusion, periportal edema, and distended intestines occurred more frequently in patients who were resuscitated compared to those who were not. Postmortem clotting was seen less often in resuscitated patients (p = 0.002). Distended intestines and loss of grey-white matter differentiation in the brain showed a significant correlation with postmortem time interval (p = 0.001, p
Total-body CT and MR features of postmortem change in in-hospital deaths Ivo M. Wagensveld1,2*, Britt M. Blokker1,2, Piotr A. Wielopolski1, Nomdo S. Renken3, Gabriel P. Krestin1, Myriam G. Hunink1,4, J. Wolter Oosterhuis2, Annick C. Weustink1,2 1 Department of Radiology and Nuclear Medicine, Erasmus University Medical Centre, Rotterdam, ZuidHolland, The Netherlands, 2 Department of Pathology, Erasmus University Medical Centre, Rotterdam, ZuidHolland, The Netherlands, 3 Department of Radiology, Reinier de Graaf Gasthuis, Delft, Zuid-Holland, The Netherlands, 4 Centre for Health Decision Science, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, United States of America
a1111111111 a1111111111 a1111111111 a1111111111 a1111111111
* [email protected]
Abstract Objectives
OPEN ACCESS Citation: Wagensveld IM, Blokker BM, Wielopolski PA, Renken NS, Krestin GP, Hunink MG, et al. (2017) Total-body CT and MR features of postmortem change in in-hospital deaths. PLoS ONE 12(9): e0185115. https://doi.org/10.1371/ journal.pone.0185115 Editor: Andrew Churg, University of British Columbia, CANADA Received: June 15, 2017 Accepted: September 5, 2017 Published: September 27, 2017 Copyright: © 2017 Wagensveld et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant data are within the paper and its Supporting Information file. Funding: The following funders supported this work: Erasmus MC health care efficiency, 201010112; Stichting Coolsingel (NL), 255; Erasmus MC vriendenfonds, 104117. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
To evaluate the frequency of total-body CT and MR features of postmortem change in inhospital deaths.
Materials and methods In this prospective blinded cross-sectional study, in-hospital deceased adult patients underwent total-body postmortem CT and MR followed by image-guided biopsies. The presence of PMCT and PMMR features related to postmortem change was scored retrospectively and correlated with postmortem time interval, post-resuscitation status and intensive care unit (ICU) admittance.
Results Intravascular air, pleural effusion, periportal edema, and distended intestines occurred more frequently in patients who were resuscitated compared to those who were not. Postmortem clotting was seen less often in resuscitated patients (p = 0.002). Distended intestines and loss of grey-white matter differentiation in the brain showed a significant correlation with postmortem time interval (p = 0.001, p
