*Mattias Brunström, Bo Carlberg [email protected] Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden 1
Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014; 384: 1929–35.
I read with interest the meta-analysis by Jonathan Emberson and colleagues,1 but would have appreciated heterogeneity assessments for the major outcomes in the meta-analysis. The validity of any meta-analysis depends on the underlying clinical and statistical heterogeneity. 2 If clinical heterogeneity is substantial (ie, clinical features, such as setting, disease spectrum, or populations studied are highly variable), or if statistical heterogeneity suggests that results are affected by more than chance (typically p
Emberson J, Lees KR, Lyden P, et al. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014; 384: 1929–35.
I read with interest the meta-analysis by Jonathan Emberson and colleagues,1 but would have appreciated heterogeneity assessments for the major outcomes in the meta-analysis. The validity of any meta-analysis depends on the underlying clinical and statistical heterogeneity. 2 If clinical heterogeneity is substantial (ie, clinical features, such as setting, disease spectrum, or populations studied are highly variable), or if statistical heterogeneity suggests that results are affected by more than chance (typically p
