Thrombin inhibition by hirudin: how hirudin inhibits thrombin.

Inhibition of thrombin by synthetic hirudin peptides.

Refined structure of the hirudin-thrombin complex.

Modulation of thrombin-hirudin interaction by specific ion effects.

Determination of r DNA hirudin and A-human thrombin- hirudin complex in plasma samples: enzyme linked immunosorbent assays for hirudin and complex vs. chromogenic thrombin substrate assay.

Ionic interactions in the formation of the thrombin-hirudin complex.

Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1-51).

Pharmacokinetic investigations of the alpha-human thrombin-hirudin complex in rhesus monkeys.

Conformational stability of a thrombin-binding peptide derived from the hirudin C-terminus.

Structural differences in active site-labeled thrombin complexes with hirudin isoinhibitors.

Binding of hirudin to human alpha, beta and gamma-thrombin. A comparative kinetic and thermodynamic study.

The structure of a complex of recombinant hirudin and human alpha-thrombin.

Structure-function and refolding studies of the thrombin-specific inhibitor hirudin.

Electrostatic interactions in the association of proteins: an analysis of the thrombin-hirudin complex.

Effect of thrombin inhibitors on platelet functions: comparative analysis of DuP 714 and hirudin.

Hirudin.

Refinement of the thrombin-bound structure of a hirudin peptide by a restrained electrostatically driven Monte Carlo method.

Radioimmunoassay for the detection of active-site specific thrombin inhibitors in biological fluids. II. Heparin affects the binding of hirudin to alpha-thrombin.

Comparison of thrombin-antithrombin complex (TAT) levels and fibrinopeptide A following thrombin incubation of human plasma using hirudin as an inhibitor of TAT formation.

Heparin today, hirudin tomorrow?

Laboratory use of hirudin.

Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.

Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors.

Effect of recombinant hirudin, a specific inhibitor of thrombin, on endotoxin-induced intravascular coagulation and acute lung injury in pigs.

Toxicology of hirudin.

Suggest Documents

Inhibition of thrombin by synthetic hirudin peptides.

Refined structure of the hirudin-thrombin complex.

Modulation of thrombin-hirudin interaction by specific ion effects.

Determination of r DNA hirudin and A-human thrombin- hirudin complex in plasma samples: enzyme linked immunosorbent assays for hirudin and complex vs. chromogenic thrombin substrate assay.

Ionic interactions in the formation of the thrombin-hirudin complex.

Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1-51).

Pharmacokinetic investigations of the alpha-human thrombin-hirudin complex in rhesus monkeys.

Conformational stability of a thrombin-binding peptide derived from the hirudin C-terminus.

Structural differences in active site-labeled thrombin complexes with hirudin isoinhibitors.

Binding of hirudin to human alpha, beta and gamma-thrombin. A comparative kinetic and thermodynamic study.

The structure of a complex of recombinant hirudin and human alpha-thrombin.

Structure-function and refolding studies of the thrombin-specific inhibitor hirudin.

Electrostatic interactions in the association of proteins: an analysis of the thrombin-hirudin complex.

Effect of thrombin inhibitors on platelet functions: comparative analysis of DuP 714 and hirudin.

Hirudin.

Refinement of the thrombin-bound structure of a hirudin peptide by a restrained electrostatically driven Monte Carlo method.

Radioimmunoassay for the detection of active-site specific thrombin inhibitors in biological fluids. II. Heparin affects the binding of hirudin to alpha-thrombin.

Comparison of thrombin-antithrombin complex (TAT) levels and fibrinopeptide A following thrombin incubation of human plasma using hirudin as an inhibitor of TAT formation.

Heparin today, hirudin tomorrow?

Laboratory use of hirudin.

Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogues.

Synthesis of a homologous series of ketomethylene arginyl pseudodipeptides and application to low molecular weight hirudin-like thrombin inhibitors.

Effect of recombinant hirudin, a specific inhibitor of thrombin, on endotoxin-induced intravascular coagulation and acute lung injury in pigs.

Toxicology of hirudin.

Thrombin inhibition by hirudin: how hirudin inhibits thrombin.

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