RESEARCH ARTICLE
The TP73 Gene Polymorphism (rs4648551, A>G) Is Associated with Diminished Ovarian Reserve Laura Diniz Vagnini1, Adriana Renzi1, Gabriela Ravanelli Oliveira-Pelegrin1, Maria do Carmo Tomitão Canas1, Claudia Guilhermino Petersen2, Ana Lucia Mauri2, João Batista Alcantara Oliveira2, Ricardo Luiz Razera Baruffi2, Mario Cavagna2, José Gonçalves Franco Junior2* 1 Paulista Center for Diagnosis, Research and Training, Ribeirão Preto, São Paulo, Brazil, 2 Center for Human Reproduction Prof. Franco Jr, Ribeirão Preto, São Paulo, Brazil * [email protected]
Abstract OPEN ACCESS Citation: Vagnini LD, Renzi A, Oliveira-Pelegrin GR, Canas MdCT, Petersen CG, Mauri AL, et al. (2015) The TP73 Gene Polymorphism (rs4648551, A>G) Is Associated with Diminished Ovarian Reserve. PLoS ONE 10(3): e0120048. doi:10.1371/journal. pone.0120048 Academic Editor: Wan-Xi Yang, Zhejiang University, CHINA Received: October 8, 2014 Accepted: February 3, 2015 Published: March 20, 2015 Copyright: © 2015 Vagnini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
It’s known that the members of the TP53 family are involved in the regulation of female reproduction. Studies in mice showed that the TP73 gene (member of this family) plays a role in the size of follicular pool, ovulation rate and maintenance of genomic stability. In the present study we analyzed data from 605 patients with 37 years attending their first intracytoplasmic sperm injection (ICSI). The association between the TP73 polymorphism (rs4648551, A>G) and the following parameters related to ovarian reserve, like age, antral follicular count (AFC), anti-Mullerian hormone levels (AMH) and ovarian response prediction index (ORPI) was evaluated. Our results showed an association of the AA genotype with diminished ovarian reserve (AMH
The TP73 Gene Polymorphism (rs4648551, A>G) Is Associated with Diminished Ovarian Reserve Laura Diniz Vagnini1, Adriana Renzi1, Gabriela Ravanelli Oliveira-Pelegrin1, Maria do Carmo Tomitão Canas1, Claudia Guilhermino Petersen2, Ana Lucia Mauri2, João Batista Alcantara Oliveira2, Ricardo Luiz Razera Baruffi2, Mario Cavagna2, José Gonçalves Franco Junior2* 1 Paulista Center for Diagnosis, Research and Training, Ribeirão Preto, São Paulo, Brazil, 2 Center for Human Reproduction Prof. Franco Jr, Ribeirão Preto, São Paulo, Brazil * [email protected]
Abstract OPEN ACCESS Citation: Vagnini LD, Renzi A, Oliveira-Pelegrin GR, Canas MdCT, Petersen CG, Mauri AL, et al. (2015) The TP73 Gene Polymorphism (rs4648551, A>G) Is Associated with Diminished Ovarian Reserve. PLoS ONE 10(3): e0120048. doi:10.1371/journal. pone.0120048 Academic Editor: Wan-Xi Yang, Zhejiang University, CHINA Received: October 8, 2014 Accepted: February 3, 2015 Published: March 20, 2015 Copyright: © 2015 Vagnini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
It’s known that the members of the TP53 family are involved in the regulation of female reproduction. Studies in mice showed that the TP73 gene (member of this family) plays a role in the size of follicular pool, ovulation rate and maintenance of genomic stability. In the present study we analyzed data from 605 patients with 37 years attending their first intracytoplasmic sperm injection (ICSI). The association between the TP73 polymorphism (rs4648551, A>G) and the following parameters related to ovarian reserve, like age, antral follicular count (AFC), anti-Mullerian hormone levels (AMH) and ovarian response prediction index (ORPI) was evaluated. Our results showed an association of the AA genotype with diminished ovarian reserve (AMH
