TERATOLOGY 43: 371-408 (1991)

THE TERATOLOGY SOCIETY TH IRTY-FIRST ANNUAL MEETING JUNE 22-27, 1991 AND

THE INTERNAT ONAL FEDERAT ON OF TERATOLOGY SOCIETIES THIRD MEETING

JUNE 24-25, 1991 THE BOCA RATON HOTEL AND CLUB BOCA RATON, FLORIDA

Program, Abstracts

0

1991 WILEY-LISS, INC.

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TERATOLOGY SOCIETY OFFICERS 1990-91 CAROLE A. KIMMEL President RICHARD K. MILLER President-Elect JEANNE M. MANSON Secretary (1988-91)

RONALD P. JENSH Treasurer (1990-92)

JAMES W. HANSON (1988-911, KATHLEEN K. SULIK (1989-92), JOSE F. CORDER0 (1990-93) Council Members

Past-Presidents of the Society J. WARKANY 1960-61 J.G. WILSON 1961-62 F.C. FRASER 1962-63 M.M. NELSON 1963-64 D.A. KARNOFSKY 1963-64 L.W. MONIE 1964-65 S.Q. COHLAN 1965-66 M.N. RUNNER 1966-67 R.L. BRENT 1967-68 T.H. SHEPARD 1968-69

R.W. MILLER 1969-70 J. LANGMAN 1970-71 S. PRUZANSKY 1971-72 D.G. TRASLER 1972-73 J.R. MILLER 1973-74 E.M. JOHNSON 1974-75 L.S. HURLEY 1975-76 J.L. SEVER 1976-77 E.V. PERRIN 1977-78 A.B. BEAUDOIN 1978-79 R.M. HOAR 1979-80 ALEXANDRAVENTURA Executive Secretary TERATOLOGY SOCIETY 9650 Rockville Pike Bethesda, Maryland 20814 301-571-1841 FAX 301-530-7133

C.R. SWINYARD 1980-81 W.J. SCOTT, JR. 1981-82 D.M. KOCHHAR 1982-83 R.E. STAPLES 1983-84 G.P. OAKLEY, JR. 1984-85 L.B. HOLMES 1985-86 A.G. HENDRICKX 1986-87 C.T. GRABOWSKI 1987-88 M.S. CHRISTIAN 1988-89 E.F. ZIMMERMAN 1989-90

TERATOLOGY SOCIETY PROGRAM

TERATOLOGY SOCIETY COMMITTEES 1990-91 (Date indicates year of expiration of term of office) NOMINATIONS AND ELECTIONS (1990-91) William Slikker, Jr., Chair-1991 Robert L. Clark-1991 Lewis B. Holmes--1992 Patricia M. Rodier-1992 Ernest F. Zimmerman, Past Pres. PUBLICATION Editor-in-Chief Robert L. Brent-1992 (ex-oficio) Publication Committee Thomas E. Kwasigroch, Chair-1991 Patricia M. Rodier-1993 William P. Jollie-1995 Section Editors Charles Vorhees-1991 H. Eugene Hoyme-1992 Barbara F. Hales-1992 John C. Carey-1992 F. David Erikson-1992 Frederick R. Bieber-1992 John L. Sever-1992 David A. Beckman-1993 B.K. Nelson-1994 John M. Graham-1995 Mont R. Juchau-1995 Thomas B. Knudsen-1995 Diana M. Juriloff-1995 Others Nigel Brown-1991 Liaison (ex-officio) Mineo Yasuda-1993 Liaison (ex-officio) Gregory St. John, John Wiley Publications Carole A. Kimmel, President (ex-officio) CONSTITUTION AND BYLAWS Judith Parker, Chair-1991 Richard A. Byrd-1992 Donna R. Farmer-1993 MEMBERSHIP John W. Larsen, Jr., Chair-1991 Elaine M. Faustman-1992 Jacqueline A. Gray-1993 LIAISONS WITH OTHER SOCIETIES (1990-91) ACOG-John W. Larsen, Jr. AALAC-Gary L. Kimmel ACT-Mildred S. Christian MARTA-Alan M. Hoberman MTA-Janet Markham

SOT-Bernard A. Schwetz American Academy of Pediatrics Robert L. Brent American Society of Human Genetics John M. Graham, Jr. CORN-Frank Greenberg FINANCE Ronald P. Jensh-1992 John M. DeSesso-1992 Richard K. Miller-1991 PUBLIC AFFAIRS William J. Scott, Jr., Chair-1991 Donald E. Hutchings-1991 Godfrey P. Oakley, Jr.-1991 Mason Barr, Jr.-1991 Thomas A. Marks-1991 Patrick J. Wier-1992 Elaine Z. Francis-1992 Anthony Scialli-1992 Paul W.J. Peters-1992 J a n M. Friedman-1993 Elaine M. Faustman-1993 Richard A. Byrd-1993 Bernard A. Schwetz-1993 Richard K. Miller, Pres.-Elect (ex-oficio) Carole A. Kimmel, President (ex-officio) EDUCATION Ronald D. Hood, Chair-1991 Richard M. Hoar-1991 Robert J. Kavlock-1992 Robert M. Greene-1992 Edward J. Lammer-1993 Maureen H. Feuston-1993 STUDENT AFFAIRS Robert M. Greene, Chair-1991 Allen S. Goldman-1992 Martha E. Sucheston-1993 Patrick J. Wier (ad hoc) Barbara D. Abbott (ad hoc) EXECUTIVE SECRETARY Alexandra Ventura AD HOC COMMITTEES TERATOLOGY IN THE YEAR 2000 Richard K. Miller, Chair Ernest F. Zimmerman Carole A. Kimmel

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Kathleen K. Sulik James W. Hanson Jose F. Cordero Robert M. Greene Narsingh D. Agnish LEGISLATIVE AFFAIRS Anthony R. Scialli, Chair James W. Hanson Gary L. Kimmel James C. Lamb, 1V Ernest F. Zimmerman Carole A. Kimmel (ex-officio) TERATOLOGY INFORMATION SERVICES Jaime L. Frias, Chair Jane OBrien

James W. Hanson Jose F. Cordero Frank Greenberg SEARCH COMMITTEE-EDITOR-INCHIEF Casimer T. Grabowski, Chair John M. Graham, Jr. William P. Jollie Patricia M. Rodier Bernard A. Schwetz 1991 PROGRAM COMMITTEE John M. DeSesso, Chair Elaine Z. Francis Kenneth M. Rosenbaum Carole A. Kimmel

SUSTAINING MEMBERS - 1991" ABBOT LABORATORIES BIOIDYNAMICS, INC BURROUGHS WELLCOME CO COCA-COLA COMPANY DOW CORNING CORPORATION E. I. DU PONT DE NEMOURS GENENTECH, INC HAZLETON LABORATORIES HOECHST CELANESE CORP HOFFMANN LA ROCHE, INC MARION-MERRELL DOW, INC

MITRE CORPORATION MOBIL OIL CORP MONSANTO COMPANY PHARMAKON RESEARCH INSTITUTE PROCTER & GAMBLE CO STERLING DRUG SYNTEX RESEARCH UNION CARBIDE WARNER LAMBERT COMPANY PARKE-DAVIS PHARMACEUTICAL DIV JOHN WILEY & SONS

*Listing as of February publication deadline. The Teratology Society is pleased to acknowledge contributions from the following companies to support the 1990 Annual Meeting. Due to early printing deadlines, some of the organizations below were not included in last year's program: ABBOT LABORATORIES AMERICAN INDUSTRIAL HEALTH COUNCIL ARGUS RESEARCH LABORATORIES, INC BIO-RESEARCH LABORATORIES, LTD BRISTOL-MYERS/SQUIBB CIBA-GEIGY CORPORATION COCA-COLA COMPANY DOW DORNING CORPORATION EXXON BIOMEDICAL SCIENCES ELI LILLY & COMPANY GENETECH, INC STEPHEN B. HARRIS GROUP

HOFF-LAROCHE, INC MARCH OF DIMES MARION-MERRELL DOW, INC MERCK SHARP & DOHME RESEARCH LABORATORIES MILES INClBAYER AG SCHERING-PLOUGH RESEARCH G.D. SEARLE & COMPANY SMITHKLINE BEECHAM SPRINGBORN LIFE SCIENCES, INC STERLING RESEARCH GROUP WARNER-LAMBERT COMPANY PARKE-DAVIS PHARMACEUTICAL DIV WYETH-AYERST LABORATORIES

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The Teratology Society also is pleased to acknowledge contributions from the following companies to support the 1991 Annual Meeting. Additional contributors to the 1991 Annual Meeting will be listed on a n insert in this year’s program and in the 1992 Annual Meeting program which will appear in the May 1992 issue of TERATOLOGY. COCA-COLA COMPANY DOW CORNING CORPORATION EXXON BIOMEDICAL SCIENCES

MARION-MERRELL DOW, INC UNION CARBIDE UPJOHN COMPANY EXHIBITORS*

*A complete listing of the exhibitors at the 1991 Annual Meeting will appear in the program of the meeting.

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PROGRAM SYNOPSIS TERATOLOGY SOCIETY NEUROBEHAVIORAL TERATOLOGY SOCIETY INTERNATIONAL FEDERATION TERATOLOGY SOCIETIES AM

Saturday, June 22

8:OO-1O:OO Registration (Joint) Grand Hall North 9:00-12:00 Council Meeting-NBTS Vidal Room (Tower)

1:OO-6:00

PM

Symposium-NBTS

Granada A B Course Registration Grand Hall North 3:15-7:lO Course Barcelona ABC Reception-Course 7:10-8:00 Cloister Garden 8:00-11:00 Dinner Valencia 2:30-3:15

Sunday, June 23 9:00-6:00 8:00-12:30 9:oo-1200 9:OO-5:OO 8:00-5:00

Registration (Joint) Grand Hall North Course Barcelona ABC Public Affairs Committee Seuille Room Council Meeting Vidal Room (Tower) Symposium-NBTS Granada A B

1:00-3:00 3:OO -5100 3:00-5:00 3:OO-5:00 6:30-7:30

Publications Committee Seuille Room Discussion Group 1 Madrid Room Discussion Group 2 Granada C Discussion Group 3 Granada D President’s Reception Garden Pool

Monday, June 24 Registration, Exhibitors Great Hall North Warkany Lecture (Joint) 8:15-9:00 Great Hall South 9:oo-1o:oo Spouse Coffee Southeast Kingman 9:15-12:OO Symposium I Great Hall South 9:30-12:00 Symposium-NBTS Granada A B

7:00-9:00

12:00-1:30 Wilson Lunch Cathedral Room 1:30-5:00 Symposium I1 (Joint) Great Hall South 1:30-3:00 Platform Session I-A Granada A B 1:30-3:00 Platform Session I-B Granada CD 3:30-500 Platform Session 11-A Granada A B Platform Session 11-B 3:30-5:00 Granada CD 7:00-9:00 Poster Session I (Joint) Camino Hall 9:oo-1o:oo Poster Discussion I-A Madrid 9:oo-1o:oo Poster Discussion I-B Granada A B 9:oo-1o:oo Poster Discussion I-C Granada CD

377

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Tuesday, June 25

AM

PM

Past President's Luncheon Northeast Kingman (Tower) LOO-5:OO Cont Education-1FTS Barcelona 1:30-3:30 Workshop I Madrid 1:30-3:30 Minicourse I Granada A B 1:30-3:00 Minicourse I1 Granada CD 3:45-5:15 Workshop I1 Granada A B 3:45-5:15 Workshop 111 Madrid 3:45-5:15 Platform Session V Granada CD 5:15-6:45 Business Mtg Great Hall South 7:30-10:30 Theme Dinner Boca Beach Club

Registration, Exhibitors Great Hall North 8:30-12:OO Symposium I11 (Joint) Great Hall South 8:30-1O:OO Platform Session Ill-A Granada A B 8:30-1O:OO Platform Session XII-B Granada CD 10:30-12:OO Platform Session IV-A Granada A B 10:30-12:OO Platform Session IV-B Granada CD 7:OO-7:00

12:OO-1:30

Wednesday, June 26 7:OO-7:00 8:OO-1O:OO

10:30-12:OO 10:30-1200 10:30-1200

Registration, Exhibitors Great Hall North Symposium IV Great Hall South Platform Session VI-A Granada A B Platform Session VI-B Granada CD Platform Session VI-C Madrid Room

1:30-4:00 4:OO-5:00 4:OO-5:00 4:OO-5:00 6:30-7:30 7:30-1O:OO

Poster Session I1 Camino Hall Poster Discussion 11-A Granada A B Poster Discussion 11-B Granada CD Poster Discussion 11-C Madrid Room Reception Garden Pool Banquet Great Hall South

Thursday, June 27 Registration, Exhibitors Great Hall North 8:OO-1O:OO Symposium V Great Hall South 10:30-1200 Platform Session VII-A Granada AB 10:30-12:OO Platform Session VII-B Granada CD 10:30-1200 Platform Session VII-C Madrid Room 7:OO-12:OO

1200-1:30

Council I1 Meeting Vidal Room (Tower)

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PROGRAM SATURDAY, JUNE 22 CONTINUING EDUCATION COURSE

Barcelona, 2:30-7:lO P.M. HUMAN DEVELOPMENTAL TOXICANTSTHE EXPERIMENTAL AND EPIDEMIOLOGICAL EVIDENCE SPONSORED BY THE EDUCATION COMMITTEE OF THE TERATOLOGY SOCIETY Ronald D. Hood, Chairperson

Preregistration is required-contact Alexandra Ventura for information: (301)571-1841

2:30-3:15

Pick up course materials

3:15-3:30

INTRODUCTION. Ronald D. Hood, University of Alabama, “uscaloosa, Alabama

3:30-5:00

EPIDEMIOLOGIC METHODS. J. David EricksodMuin J. Khoury, Centers for Disease Control, Atlanta, Georgia

500-5: 10

QUESTIONS AND ANSWERS

5 :10-5~30

BREAK

5:30-7:00

EPIDEMIOLOGIC METHODS, CONTINUED. J. David EricksoniMuin J. Khoury, Centers for Disease Control, Atlanta, Georgia

7:00-7:10

QUESTIONS AND ANSWERS

7:10-8:00

GET ACQUAINTED RECEPTION-Cloister

8:OO

DINNER-Vulencza

Garden

SUNDAY, JUNE 23 EDUCATION COURSE, CON’T

Barcelona, 8:OO A.M.-12:30 P.M. 8:00-8:50

VALPROIC ACID-AN ACHIEVEMENT OF EPIDEMIOLOGY. Heinz Nau, Freie Universitat Berlin, Berlin, Germany/Godfrey P. Oakley, Jr., Centers for Disease Control, Atlanta, Georgia

8:50-9:40

RETINOIDS-PREDICTED BY ANIMAL STUDIES. Kathleen K. Sulik, University of North Carolina, Chapel Hill, North Carolina

9:40-9:55

QUESTIONS AND ANSWERS

9:55-10:20

BREAK

10:20-11:lO

METHYLMERCURY-AN ENVIRONMENTAL TERATOGEN. Patricia M. Rodier, University of Rochester, Rochester, NY

11:lO-12:oo

BENDECTIN-AN APPARENT HUMAN NONTERATOGEN. Lewis B. Holmes, Massachusetts General Hospital, Boston, Massachusetts

12:00-12:15

QUESTIONS AND ANSWERS

12:15-12~30

CONCLUDING ANNOUNCEMENTS AND COURSE EVALUATION

TERATOLOGY SOCIETY PROGRAM

379

9:00-6:00

REGISTRATION-Greut Hull North

9:00-12:00

PUBLIC AFFAIRS COMMITTEE-Seuille Room

1:00-3:00

PUBLICATIONS COMMITTEE-Seuille Room

9:00-5:00

COUNCIL I MEETING-Vidul

3:00-5:00

DISCUSSION GROUPS 1. RISK ASSESSMENT. Bern Schwetz and Joseph Holson, Discussion Leaders (Sponsored by A1HC)-Madrid Room 2. CELLULAR SIGNAL TRANSDUCTION DURING NORMAL AND ABNORMAL EMBRYOGENESIS. Allen Goldman and Robert Greene, Discussion Leaders-Grunadu C 3. MECHANISMS OF RETINOID ACTIVITY. Devendra Kochhar and Barbara Abbott, Discussion Leaders-Granada D

6:30-7:30

PRESIDENTS RECEPTION (Joint Teratology Society and Neurobehavioral Teratology Society)-Garden Pool

Room (Tower)

MONDAY, JUNE 24 Great Hall South 8:15-8:30

OPENING REMARKS AND INTRODUCTION TO WARKANY LECTURE. Carole A. Kimmel, President of the Teratology Society, U.S. Environmental Protection Agency, Washington, DC

8:30-9:00

THE JOSEF WARKANY LECTURE: A PERSONAL PERCEPTION OF PUBLIC PERCEPTIONS OF TERATO/GENETIC RISKS. F. Clarke Fraser, McGill Centre for Human Genetics, Montreal, Canada

9:00-9:15

BREAK

SYMPOSIUM I THE WILEY-LISS SYMPOSIUM Great Hall South, 9:15 A.M.-12:OONOON ORGANIZATIONAL CONTROL IN THE EMBRYO: POTENTIAL TARGETS FOR DEVELOPMENTAL TOXICANTS John M. DeSesso, Organizer and Chair 9:15-9:30

OPENING REMARKS AND INTRODUCTION. John M. DeSesso, MITRE Corporation, McLean, Virginia

9:30-10:00

1-1 TOPOBIOLOGY: CELL ADHESION AND MORPHOGENESIS. Kathryn L. Crossin and Gerald M. Edelman, Rockefeller University, New York, New York

10:00-10:30

1-2 EPITHELIAL-MESENCHYMAL TRANSFORMATIONS IN PALATOGENESIS AND EARLY EMBRYOGENESIS. Elizabeth D. Hay, Harvard Medical School, Boston, Massachusetts

10:30-10:45

BREAK

10:45-11:15

1-3 EPITHELIAL-MESENCHYMAL TRANSFORMATION IN THE DEVELOPING HEART: ROLE OF MYOCARDIAL ADHERON. Roger R. Markwald, Krug, E.L. Medical College of Wisconsin, Milwaukee, Wisconsin

380

TERATOLOGY SOCIETY PROGRAM

11:15-11:45

1-4 INSERTIONAL MUTAGENESIS AND THE MOLECULAR ANALY-

SIS OF MOUSE MUTATIONS. Richard P. Woychik, Oak Ridge National Laboratory, Oak Ridge, Tennessee 11:45-12:00

DISCUSSION

12:00-1:30

WILSON LUNCHEON (Featuring awards for graduate students and postdoctoral fellows, all registrants are invited to attend)-Cathedral Room

SYMPOSIUM I1 Great Hall South, 1:30 P.M.- 5:OO P.M.

IMPROVING APPROACHES TO THE CHARACTERIZATION OF DEVELOPMENTAL NEUROTOXICITY Jointly Sponsored by the Teratology Society, the International Federation of Teratology Societies, and the Neurobehavioral Teratology Society J u d y Buelke-Sam, William J. Pizzi, and Takashi Tanimura, Organizers 1:30-1:40

OPENING REMARKS. J. Buelke-Sam, Lilly Research Laboratories, Greenfield, Indiana

1:40-2:00

11-1 UPDATE ON THE ACTIVITIES OF THE JAPANESE BEHAVIORAL

TERATOLOGY MEETING. T. Tanimura, Kinki University School of Medicine, Osaka, Japan 2:oo-2:20

11-2 ISSUES OF HUMAN EXPOSURE TO AGENTS CAUSING DEVELOPMENTAL TOXICITY. S. Tabacova and M. Vukov, Medical Academy, Sofia, Bulgaria

2:20-2:40

11-3 EXPOSURE PERIOD CONSIDERATIONS IN DEVELOPMENTAL NEUROTOXICITY ASSESSMENTS. B.K. Nelson, National Institute of Occupational Safety and Health, Cincinnati, Ohio

2140-3~05

11-4 ADVANTAGES AND DISADVANTAGES OF LONGITUDINAL AS-

SESSMENT OF OFFSPRING FUNCTION. S.K. Sobrian, Howard University College of Medicine, Washington, DC 3:05-3:25

BREAK

3:25-3:50

11-5 CRITICAL PERIODS FOR OFFSPRING NEUROBEHAVIORAL AS-

SESSMENT. L.P. Spear, SUNY Binghamton, Binghamton, New York 3:50-4:15

11-6 AN OVERVIEW OF NEUROCHEMICAL ASSESSMENTS OF DEVELOPMENTAL NEUROTOXICITY. J.P. OCallaghan, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina

4: 15-4:40

11-7 CRITICAL PERIODS FOR MORPHOLOGIC ASSESSMENTS. P.M. Rodier, University of Rochester, Rochester, New York

4:40-5:00

GENERAL DISCUSSION

TERATOLOGY SOCIETY PROGRAM

381

PLATFORM SESSION I-A Granada AB, 1:30 P.M.-3:00 P.M. PREVENTION/AMELIORATION OF DEVELOPMENTAL TOXICITY Stephen B. Harris, Chair 1:30-1:45

1 AMELIORATION OF THE EMBRYOTOXICITY OF HYDROXYUREA IN WHOLE EMBRYO CULTURE WITH ANTIOXIDANT SUBSTANCES. Collins, M., V. Richburg”, W.J. Scott, and J.M. DeSesso, Children’s Hospital Research Foundation, Cincinnati, Ohio and MITRE Corporation, McLean, Virginia

1:45-2:00

2 ATTENUATION OF HYDROXYUREA-INDUCED EMBRYOTOXICITY BY DEOXYADENOSINE. Grafton*, T.F., D.R. Cross*, S.J. James*, and D.K. Hansen, Divisions of Reproductive and Developmental Toxicology and Comparative Toxicology, National Center for Toxicological Research, Jefferson, Arkansas

2:00-2:15

3 THE PROTECTIVE EFFECTS OF METHIONINE AND ZINC ON ALCOHOL INDUCED EMBRYOPATHY IN THE CHICK. Gilani, S.H., L. Dalamangas* and A. Gilani*, Department of Anatomy, New Jersey Medical School, Newark, New Jersey

2:15-2:30

4 DIABETIC EMBRYOPATHY: PROSTAGLANDIN E2 PREVENTS ANOMALIES PRODUCED BY DIABETIC SERUM IN CULTURED MOUSE EMBRYOS. Goldman, A.S., and M.P. Goto*, Center for Craniofacial Anomalies and Department of Pediatrics, University of Illinois, Chicago, Illinois

2:30-2:45

5 REVERSAL OF TILORONE EMBRYOLETHALITY WITH PROGESTERONE OR INDOMETHACIN. Marks, T.A., and R.D. Terry”, Safety Pharmacology, The Upjohn Co., Kalamazoo, Michigan

2~45-3100

6 IMPACT OF MESO-2,3-DIMERCAPTOSUCCINIC ACID (DMSA) ON REPRODUCTIVE OUTCOME AND MATERNAL AND FETAL MINERAL METABOLISM IN SWISS MICE. Taubeneck*, M.W., J.L. Domingo, J.M. Llobet, and C.L. Keen, Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, Reus, Spain and Department of Nutrition, University of California, Davis, California

PLATFORM SESSION I-B Granada CD, 1:30 A.M.-3:00 P.M. DYSMORPHOLOGY Eugene H. Hoyme, Chair 1:30-1:45

7 DETECTING HUMAN RETINOID EMBRYOPATHY. Rosa, F., Food and Drug Administration, Rockville, Maryland

1:45-2:00

8 INCREASED RECOGNITION OF “SILENT” MALFORMATIONS BY PRENATAL ULTRASONOGRAPHY. Geifman*, O.H. and L.B. Holmes, Departments of Newborn Medicine and Obstetrics and Gynecology, Brigham and Women’s Hospital, Boston, Massachusetts

2:00-2:15

9 THE ROLE OF THE SEF’TAL CARTILAGE IN FACIAL DEVELOPMENT. Howe*, A.M., and W.S. Webster, Department of Anatomy, University of Sydney, Sydney, Australia

382

TERATOLOGY SOCIETY PROGRAM

2:15-2:30

10 HEMIFACIAL MICROSOMIA ASYMMETRY: SOFT TISSUE HYPOPLASIA OR CRANIAL BONE DISPLACEMENT? Millicovsky, G., J. Cabrera*, and I. Munro*, Humana Advanced Surgical Institutes, Medical City Dallas, Dallas, Texas

2:30-2:45

11 SIRENOMELIA AND CAUDAL REGRESSION-TWO DISTINCT ENTITIES? Colwell*, K.A., V.J. Baldwin*, S.L. Yong*, Departments of Medical Genetics and Pathology, University of British Columbia, Vancouver, Canada (Introduced by J.M. Friedman)

2:45-3:00

12 SCANNING ELECTRON MICROSCOPY OF EARLY MOUSE EMBRYOS WITH CHROMOSOME TRANSLOCATION. Shepard, T.H., A. Dyban*, J.C. Rutledge, N.L.A. Cacheiro*, and W.M. Generoso*, Departments of Pediatrics & Pathology, University of Washington, Seattle, Washington, Department of Embryology, Institute for Experimental Medicine, Academy of Medical Science, Leningrad, USSR, and Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

3:00-3:30

BREAK

PLATFORM SESSION 11-A Granada AB, 3:30 P.M.-5:00 P.M. MOLECULAR MECHANISMS OF DEVELOPMENT Ernest Zimmerman, Chair 3:30-3:45

13 INDUCTION OF A STRESS RESPONSE AND ABNORMAL DEVELOPMENT IN RAT EMBRYOS EXPOSED IN VITRO TO SODIUM ARSENITE. Cornel*, L.M., B.M. Doggett", S.A. Little, and P.E. Mirkes, University of Washington, Seattle, Washington

3:45-4:00

ROLE OF THE CELL CYCLE IN CYCLOPHOSPHAMIDE (CP) IN14 DUCED TERATOGENESIS. Little, S.A., A. MacAuley*, and P.E. Mirkes, Department of Pediatrics, University of Washington, Seattle, Washington

4:00-4:15

15 WARFARIN DIFFERENTIALLY ALTERS THE EXPRESSION OF VITAMIN K DEPENDENT BONE PROTEINS DURING DEVELOPMENT IN VITRO. Barone", L., M.A. Aronow*, J.B. Lian*, G.S. Stein*, and M.S. Tassinari, Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts

4:15-4:30

16 ALTERATION OF THE N-CAM POLYPEPTIDE PROFILE IN SPLOTCH NEURAL TUBE DEFECT MOUSE MUTANTS. Moase, C.E. and D.G. Trasler, Department of Biology and Centre for Human Genetics, McGill University, Montreal, Quebec

4:30-4:45

17 MOLECULAR ASSAY OF TERATOGENS IN THE DROSOPHILA EMBRYO. Strecker", T.R., and T.S. Shih*, Department of Biology, Pomona College, Claremont, California

4:45-5:00

18 A TRANSGENIC MOUSE MODEL FOR STUDYING TERATOGENIC EVENTS IN SPECIFIC EMBRYONIC CELL POPULATIONS. Kapur*, R.P., E. Mercer*, G. Hoyle*, R. Brinster*, and R. Palmiter*, Departments of Pathology and Biochemistry, University of Washington, Seattle, Washington (Introduced by T.H. Shepard)

TERATOLOGY SOCIETY PROGRAM

383

PLATFORM SESSION 11-B Granada CD, 3:30 P.M.-5:00 P.M. EPIDEMIOLOGY I Charlotte Ferencz, Chair 3:30-3:45

19 CLOMIPHENE CITRATE USE AND THE RISK OF BIRTH DEFECTS: A POPULATION-BASED CASE-CONTROL STUDY. Mili*, F., M.J. Khoury, and X. Lu*, CDC, Atlanta, Georgia

3:45-4:00

20 PRENATAL DRUG USE AND CONGENITAL CARDIOVASCULAR MALFORMATIONS. Rubin*, J.D., C. Loffredo*, A. Correa-Villasenor", C. Ferencz, and the Baltimore-Washington Infant Study Group, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland.

4:OO-4:15

21 EXTRAHEPATIC BILIARY ATRESIA (EHBA) AND PARENTAL FARMING AND PESTICIDE EXPOSURES. Magee*, C.M., M.S. Tockman", and P. Lees*, Department of Environmental Health, Johns Hopkins School of Hygiene, Baltimore, Maryland (Introduced by C. Ferencz)

4:15-4:30

22 TRIHALOMETHANES IN MATERNAL DRINKING WATER AND RISK FOR CONGENITAL CARDIAC ANOMALIES. Shaw*, G.M., L.H. Malcoe*, A. Milea*, and S.H. Swan*, California Birth Defects Monitoring Program, Emeryville, California (Introduced by E.J. Lammer)

4~ 30-4~ 45

23 CLASS A DIABETES MELLITUS AS A HUMAN TERATOGEN. Kousseff, B.G., and T. Diamond*, Division of Medical Genetics, University of South Florida, Tampa, Florida

4:45-5:00

24 GROWTH EFFECTS IN TWINS: CLINICAL IMPLICATIONS. Barr, M. and G. Pridjian, Departments of Obstetrics, Pediatrics and Pathology, University of Michigan, Ann Arbor, Michigan

POSTER SESSION I Camino Hall, 7:OO P.M.- 9:00 P.M. Jointly Sponsored b y the Teratology Society, the International Federation of Teratology Societies, and the Neurobehavioral Teratology Society (Posters should be set u p after 9:00 A.M. Monday m o r n i n g and removed by noon on Tuesday. Numbers P25-P42 should be attended from 7:OO P.M.-8:00 P.M. and Numbers P43-P60 attended from 8:OO P.M.-9:00 P.M.) Refreshments Available P25 TERATOLOGICAL INTERACTION BETWEEN ACETAZOLAMIDE AND ANTIFUNGAL AZOLE DERIVATIVES. Tiboni", G.M. and W.J. Scott, Children's Hospital Research Foundation, Cincinnati, Ohio

P26 ONTOGONY OF METHYLENEDIOXYMETHAMPHETAMINE (MDMA)-INDUCED NEUROTOXIC SENSITIVITY. Broening*, 111,H.W., G.D. Newport", S.F. Ali* and W. Slikker, Jr., Division of Reproductive and Developmental Toxicology, National Center for Toxicological

384

TERATOLOGY SOCIETY PROGRAM

Research, Jefferson, Arkansas, and Division of Interdisciplinary Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas P27 CRITICAL PERIOD OF RAT DEVELOPMENT WHEN SIDEDNESS OF ASYMMETRIC BODY STRUCTURES IS DETERMINED. Fujinaga, M., and J. M. Baden, Department of Anesthesia, Stanford University School of Medicine, Stanford, California and Palo Alto V.A. Medical Center, Palo Alto, California P28 MATERNAL/FETAL PLASMA DISPOSITION OF COCAINE (C) IN NEAR-TERM MACAQUE MONKEYS AND PRELIMINARY RESULTS OF CHRONIC C ADMINISTRATION ON THE DEVELOPING FETUS, MATERNAL WEIGHT GAIN AND PARTURITION TIMING. Bailey", J.R., M.G. Paule", C.M. Fogle*, M.P. Gillam*, H.M. Duhart* and W. Slikker, Jr., Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas P29 PRELIMINARY FINDINGS WITH GESTATIONAL COCAINE EXPOSURE IN THE RAT. Valentine*, J., F.M. Scalzo, C. Stewart*, H.M. Duhart", C. Wilson*, S.F. Ali* and W. Slikker, Jr., Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, and Departments of Pediatrics and Pharmacology and Toxicology, University of Arkansas for Medical Science, Jefferson, Arkansas P30 DEVELOPMENTAL TOXICITY OF COCAINE AND ITS METABOLITES IN VITRO. Hunter', E.S., and T.W. Sadler', 'NTP, Developmental and Reproductive Toxicology, NIEHS, Research Triangle Park, North Carolina, and 'Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina P31 PHARMACOKINETICS AND PLASMA DISTRIBUTION PROFILES OF COCAINE (C) IN CHRONICALLY OR ACUTELY EXPOSED RHESUS MONKEYS. Duhart*, H.M., C.M. Fogle*, M.P. Gillam", J.R. Bailey*, W. Slikker, Jr. and M.G. Paule*, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas P32 TERATOGENESIS OF COCAINE IN THE MOUSE. Fisher*, J.E., E. Resnick* and E.F. Zimmerman, Children's Hospital Research Foundation, Cincinnati, Ohio P33 CORRELATION OF THE EFFECTS OF COCAINE WITH INTRAEMBRYONIC DRUG LEVELS IN IN VITRO CULTURED CHICKEN EMBRYOS. Burin*, G.J. and K.M. Brown*, Department of Biological Sciences, George Washington University, Washington, DC P34 COMPARATIVE ABSORPTION AND DISTRIBUTION OF RADIOLABELED TRICHLOROACETONITRILE (TCAN) IN PREGNANT RATS FROM CORN OIL (CO) AND TRICAPRYLIN (TCAP) VEHICLES. Gordon*, D.A., T.K. Wessendarp*, W. Cracker*, M.K. Smith and A.C. Roth", HERL, USEPA, Cincinnati, Ohio P35 MATERNAL HYPOCALCEMIA AND DYSTOCIA IN RATS IN LATE GESTATION CAUSED BY TREATMENT WITH MK-0217 (AMINOHYDROXYBUTYLIDINE BISPHOSPHONATE). Minsker, D.H., J.M. Manson, R.T. Robertson, C.P. Peter* and D.L. Bokelman", Merck Institute for Therapeutic Research, West Point, Pennsylvania P36 DOSE RELATED ABSORPTION AND DISTRIBUTION OF DICHLOROACETATE (DCA) IN PREGNANT LONG-EVANS RATS. Roth*, A.C., W. Cracker*, T.K. Wessendarp*, M.K. Smith and D.A. Gordon*, HERL, USEPA, Cincinnati, Ohio P37 ULTRASTRUCTURAL CHANGES IN DEVELOPING RAT UTERINE EPITHELIUM INDUCED BY TAMOXIFEN (TAM) IN VIVO AND IN VITRO. Branham, W.S., B.D. LynCook*, A. Andrews*, K. Atkins" and D.M. Sheehan, Divisions of Reproductive and Developmental Toxicology and Comparative Toxicology, and Pathology Associates, Inc., National Center for Toxicological Research, Jefferson, Arkansas

TERATOLOGY SOCIETY PROGRAM

385

P38 FERTILITY AND GENERAL REPRODUCTION STUDY OF TAZOBACTAM ADMINISTERED INTRAPERITONEALLY TO CRL:CD@(SD)BR RATS ALONE OR IN COMBINATION WITH PIPERACILLIN. Lochry', E.A., A.M. Hobermanl, R. Filler2, W.J. Dougherty*' and C.E. Traitor*2, 'Argus Research Laboratories, Inc., Horsham, Pennsylvania and 'American Cyanamid Company, Pearl River, New York P39 A TWO-GENERATION REPRODUCTION STUDY WITH HYDROQUINONE (HQ) IN RATS. *'Blacker, A.M., R.E. Schroeder, J.C. English*3, S.J. Murphy4 and W.J. Krasavage3, 'Rhone-Poulenc Inc., Research Triangle Park, North Carolina, 'Bio/dynamics Inc., East Millstone, New Jersey, 3Eastman Kodak Company, Rochester, New York, 4The Goodyear Tire & Rubber Company, Akron, Ohio P40 DIFFERENTIAL RESPONSES OF ORNITHINE DECARBOXYLASE ACTIVITY TO GLUCOCORTICOID STIMULATION IN EMBRYONIC, FETAL AND ADULT RAT TISSUES. Lau*, C., A.M. Cameron* and D.L. Hunter*, US EPA, Health Effects Research Laboratory and ManTech Environmental Technology, Research Triangle Park, North Carolina (Introduced by R.J. Kavlock) P41 CARDIOVASCULAR PHYSIOLOGY OF RAT FETUSES DURING TRANSIENT HYPOXIA INDUCED BY SODIUM NITRITE INJECTION. Grabowski, C.T., Department of Biology, University of Miami, Coral Gables, Florida P42 PATHOGENESIS OF SUPERNUMERARY KIDNEYS AND RENAL AGENESIS IN MICE. Miller*, T.A., and W.J. Scott, Jr., Children's Hospital Research Foundation, Cincinnati, Ohio P43 CELL DEATH PATTERNS ASSOCIATED WITH OCHRATOXIN A-INDUCED CRANIOFACIAL MALFORMATIONS. Wei*, X., A.J. Alles*, D.B. Dehart* and K.K. Sulik, Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina P44 SPECIFIC INHIBITION OF COLLAGEN BIOSYNTHESIS BY RETINOIC ACID IN LIMB BUD MESENCHYMAL CELLS. Kochhar, D.M., H. Jiang* and S. DeJesus*, Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania P45 EXOGENOUSLY ADMINISTERED RETINOIC ACID IS LOCALIZED IN SITES OF PHYSIOLOGICAL CELL DEATH. Alles*', A.J., R. Murakami*', W.E. Stumpr"' and K.K. Sulik', 'Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina, and 'Biological Institute, Faculty of Science, Yamaguchi University, Yamaguchi, Japan P46 A PROPOSED SITE OF ACTION FOR dCF TOXICITY DURING EARLY MOUSE DEVELOPMENT. Airhart*, M.J., C. Robbins*, J. Birchfield* and R.G. Skalko, Department of Anatomy, East Tennessee State University, Johnson City, Tennessee P47 HYPOTHESIS FOR THE PATHOGENESIS OF CONJOINED TWINS (CT). Weaver*, D.D., A.H. Lipson", W.D. Webster* and M. Nicholls*, Indiana University, Indianapolis, Indiana, University of New South Wales, Royal Alexandra Hospital for Children, University of Sydney, Sydney, Australia P48 DIFFERENCES BETWEEN ALBINO RATS AND CD1 MICE IN RESPONSE TO PRENATAL DEXAMETHASONE (DEX) EXPOSURE. Holson*, R.R., D. Hansen, D. Sheehan and J. LaBorde, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research (NCTR), Jefferson, Arkansas P49 STRAIN VARIATION IN VENOUS HETEROTAXIAS IN THE MOUSE. Biddle, F.G., and B.A. Eales*, Departments of Paediatrics and Medical Biochemistry, University of Calgary, Calgary, Alberta, Canada

386

TERATOLOGY SOCIETY PROGRAM

P50 A1 AND A2 ADENOSINE RECEPTORS IN THE EARLY GESTATION SITE OF THE MOUSE. Gao*, X., M.R. Blackburn and T.B. Knudsen, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania P51 COMPARABLE TERATOGENICITY OF DOMINANT MAGNETIC FIELD (27 MHZ) AND DOMINANT ELECTRIC FIELD 10(MHZ) RADIOFREQUENCY (RF) RADIATION IN RATS. Nelson, B.K., D.L. Conover, J.M. Lary, W.S. Brightwell, D. Werren and R.M. Edwards, NIOSH, Cincinnati, Ohio

P52 VARIABLE EFFECTS OF ELECTROMAGNETIC FIELDS ON CHICK DEVELOPMENT. Martin, A.H., Department of Anatomy, University of Western Ontario, London, Ontario, Canada P53 IN VITRO EMBRYOTOXICITY OF A SERIES OF PARA-SUBSTITUTED PHENOLS: STRUCTURE, ACTIVITY AND CORRELATION WITH IN V N O DATA. Logsdon*, T.R., L.A. Oglesby, M.T. Ebron-McCoy*, M.F. Copeland*, P.E. Beyer* and R.J. Kavlock, ManTech Environmental Technology, Inc., and Perinatal Toxicology Branch, Developmental Toxicology Division, Health Effects Research Laboratory, USEPA, Research Triangle Park, North Carolina

P54 CONTINUED EVALUATION OF STRUCTURE-ACTIVITY RELATIONSHIPS IN THE DEVELOPMENTAL EFFECTS OF ALIPHATIC ACIDS IN RATS. Narotsky*, M.G., E.Z. Francis and R.J. Kavlock, ManTech Environmental Techology, Inc., and USEPA, Washington, DC and Research Triangle Park, North Carolina P55 DEVELOPMENTAL TOXICITY OF DIPHENYL ETHER HERBICIDES IN BIRDS. Hoffman, D.J., B.A. Rattner* and C.M. Bunck*, U S . Fish and Wildlife Service, Patuxent Wildlife Research Center, Laurel, Maryland P56 DEVELOPMENTAL TOXICITY OF 4-SUBSTITUTED AMPHETAMINES IN MICE. Buttar, H.S., B.C. Foster", J.H. Moffatt" and C. Bura*, Bureau of Drug Research, Health Protection Branch, Ottawa, Ontario, Canada P57 A BIOLOGICALLY-BASED DOSE-RESPONSE MODEL FOR PREGNANCY-FLEXIBLE FEATURES. Pearce*, B.A., R.H. Luecke*', W.D. Wosilait*', E. Collins*3 and J.F. Young, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, 'Department of Engineering and 'Department of Pharmacology, University of Missouri, Columbia, Missouri, and 3Pine Bluff High School, Pine Bluff, Arkansas P58 PROTOCOL PLANNER: A MACRO-DRIVE LOTUS 1-2-3@SPREAD-SHEET CALENDAR MAKER FOR AUTOMATICALLY SCHEDULING RAT AND MOUSE TERATOLOGY STUDIES. Harmon*, J.R., Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas (Introduced by W. Slikker, Jr.) P59 COMPARISON OF FETAL RAT EXAMINATION TECHNIQUES (FIXED VS. FRESH) IN THE DETECTION OF CARDIAC MALFORMATIONS, SPECIFICALLY LEVOCARDIA. Christ*, S.A., J.L. Randall', E.J. Read" and M.K. Smith, HERL, USEPAl, Pathology Associates, Inc and 'Computer Sciences Corporation, Cincinnati, Ohio P60 THE COMBINED USE OF FLOW CYTOMETRY AND AUTOMATED SPERM MOTILITY ANALYSIS AS A SCREEN FOR MALE REPRODUCTIVE TOXICANTS. Hoyt", J.A., D.L. Abbott* and D.E. Seyler, Toxicology Division, Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana

TERATOLOGY SOCIETY PROGRAM

387

POSTER DISCUSSION SESSION I-A Madrid, 9:00 P.M.-1O:OO P.M. PATHOGENESIS Devendra M. Kochhar, Chair P41 CARDIOVASCULAR PHYSIOLOGY OF RAT FETUSES DURING TRANSIENT HYPOXIA INDUCED BY SODIUM NITRITE INJECTION. Grabowski P42 PATHOGENESIS OF SUPERNUMERARY KIDNEYS AND RENAL AGENESIS IN MICE. Miller and Scott P43 CELL DEATH PATTERNS ASSOCIATED WITH OCHRATOXIN A-INDUCED CRANIOFACIAL MALFORMATIONS. Wei et al. P44 SPECIFIC INHIBITION OF COLLAGEN BIOSYNTHESIS BY RETINOIC ACID IN LIMB BUD MESENCHYMAL CELLS. Kochhar et al. P45 EXOGENOUSLY ADMINISTERED RETINOIC ACID IS LOCALIZED IN SITES OF PHYSIOLOGICAL CELL DEATH. Alles et al. P46 A PROPOSED SITE OF ACTION FOR DCF TOXICITY DURING EARLY MOUSE DEVELOPMENT. Airhart et al. P47 HYPOTHESIS FOR THE PATHOGENESIS OF CONJOINED TWINS (CT).Weaver et al.

POSTER DISCUSSION SESSION I-B Granada AB, 9:00 P.M.- 1O:OO P.M. STRUCTURE/ACTIVITY RELATIONSHIPS Robert J. Kavlock, Chair P53 IN VITRO EMBRYOTOXICITY OF A SERIES OF PARA-SUBSTITUTED PHENOLS: STRUCTURE, ACTIVITY AND CORRELATION WITH IN VZVO DATA. Logsdon et al. P54 CONTINUED EVALUATION OF STRUCTURE-ACTIVITY RELATIONSHIPS IN THE DEVELOPMENTAL EFFECTS OF ALIPHATIC ACIDS IN RATS. Narotsky et al. P55 DEVELOPMENTAL TOXICITY OF DIPHENYL ETHER HERBICIDES IN BIRDS. Hoffman et al. P56 DEVELOPMENTAL TOXICITY OF 4-SUBSTITUTED AMPHETAMINES IN MICE. Buttar et al.

POSTER DISCUSSION SESSION I-C Granada CD, 9:00 P.M.- 1O:OO P.M. COCAINE William J. Slikker, Jr., Chair P28 MATERNAL/FETAL PLASMA DISPOSITION OF COCAINE (C) IN NEAR-TERM MACAQUE MONKEYS AND PRELIMINARY RESULTS OF CHRONIC C ADMINISTRA-

388

TERATOLOGY SOCIETY PROGRAM

TION ON THE DEVELOPING FETUS, MATERNAL WEIGHT GAIN AND PARTURITION TIMING. Bailey et al. P29 PRELIMINARY FINDINGS WITH GESTATIONAL COCAINE EXPOSURE IN THE RAT. Valentine et al. P30 DEVELOPMENTAL TOXICITY OF COCAINE AND ITS METABOLITES IN VITRO. Hunter and Sadler P31 PHARMACOKINETICS AND PLASMA DISTRIBUTION PROFILES OF COCAINE (C) IN CHRONICALLY OR ACUTELY EXPOSED RHESUS MONKEYS. Duhart et al. P32 TERATOGENESIS OF COCAINE IN THE MOUSE. Fisher et al. P33 CORRELATION OF THE EFFECTS OF COCAINE WITH INTRAEMBRYONIC DRUG LEVELS IN IN VITRO CULTURED CHICKEN EMBRYOS. Burin and Brown

TUESDAY, JUNE 25 SYMPOSIUM I11 Great Hall South, 8:30 A.M.- 12:OO NOON INTERNATIONAL REGULATORY CONCERNS Jointly Sponsored by the Teratology Society, the International Federation of Teratology Societies, and the Neurobehavioral Teratology Society Christian Baeder, Chairperson of the IFTS Committee on Regulations, Organizer 8:30-9:30

111-1 THOUGHTS ON THE DEVELOPMENT OF A TRANSNATIONAL REPRODUCTIVE TOXICITY TEST GUIDELINE AND PRESENTATION OF THE CURRENT PROPOSAL. Christian Baeder, Hoechst AG, Frankfurt, Germany, and Rolf Bass, Institut fur Arzneimittel des GA, Berlin, Germany

9:30-10:00

111-2 CONSIDERATIONS ON THE EEC PROPOSAL FROM THE VIEW OF A GOVERNMENTAL AGENCY (US). Judi Weissinger, Food and Drug Administration, Rockville, Maryland

10:00-10:30

111-3 THE CONSIDERATIONS ON THE EEC PROPOSAL FROM THE VIEW OF THE PHARMACEUTICAL INDUSTRIES IN JAPAN. Satoshi Takayama, Daiichi Pharmaceutical Co., Ltd., Japan

10:30-10:45

BREAK

10:45-11:15

111-4 THE INTERPRETATION OF TERATOLOGY AND REPRODUCTIVE TOXICITY TESTS INCLUDING THE AUSTRALIAN VIEWPOINT OF THE EEC DRAFT GUIDELINE. William S.Webster, University of Sydney, Sydney, Australia

11:15-11:45

111-5 INDEPENDENT PERSPECTIVE AND CRITIQUE REGARDING THE HARMONIZATION OF TEST GUIDELINES FOR REPRODUCTIVE AND DEVELOPMENTAL TOXICTY. E. Marshall Johnson, Thomas Jefferson University, Philadelphia, Pennsylvania

11:45-12:00

PANEL DISCUSSION

TERATOLOGY SOCIETY PROGRAM

389

PLATFORM SESSION III-A Granada AB, 8:30 A.M.-1O:OO A.M.

PHARMACOKINETICS/DOSE-RESPONSE MODELING Frank Welsch, Chair 8:30-8:45

61 A STATISTICAL MODEL FOR FETAL WEIGHT AND MALFORMATION IN DEVELOPMENTAL TOXICITY STUDIES. Ryan*', L.M., P.J. Catalano*', C.A. Kimme12, and G.L. Kimme12, 'Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts and 2Reproductive and Developmental Toxicology Branch', ORD, U.S. Environmental Protection Agency, Washington, DC

8~45-9:OO

62 BIOLOGICALLY-BASED EMPIRICAL DOSE-RESPONSE MODEL FOR CLEFT PALATE UTILIZING FETAL WEIGHT REDUCTION. Gaylor*, D.W., Biometry, National Center for Toxicological Research, Jefferson, Arkansas (Introduced by J.F. Young)

9:OO-9:15

63 A BIOLOGICALLY-BASED DOSE-RESPONSE MODEL FOR PREGNANCY-USER INTERFACE. Pearce", B.A., R.H. Luecke*', W.D. Wosilait*2, E. C o l l i n ~ "and ~ , J.F. Young, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, 'Department of Engineering, and 2Department of Pharmacology, University of Missouri-Columbia, Columbia, Missouri, and 3Pine Bluff High School, Pine Bluff, Arkansas

9:15-9:30

64 A MATHEMATICAL MODEL FOR TERATOGENIC SENSITIVITY. Luecke*', R.H., W.D. Wosilaitc2, and J.F. Young, 'Department of Chemical Engineering and 'Department of Pharmacology, University of Missouri-Columbia, Columbia, Missouri and Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas

9:30-9:45

65 A PHYSIOLOGICALLY-BASED MODEL OF GESTATION IN THE MONKEY: FRAMEWORK FOR SIMULATION OF KINETICS OF REPRODUCTIVE TOXICANTS. O'Flaherty', E.J., W. Scott2, and R. Beliles3, 'Environmental Health, University of Cincinnati, 'Children's Hospital Research Foundation, Cincinnati, Ohio, and 3U.S. EPA, Washington, D.C.

9:45-10:00

66 DEVELOPMENT OF A PHYSIOLOGICALLY-BASED DESCRIPTION OF 2-METHOXYETHANOL (2-ME) PHARMACOKINETICS IN THE PREGNANT MOUSE. Clarke*, D.O., F. Welsch, and R.B. Conolly*, CIIT, Research Triangle Park, North Carolina

PLATFORM SESSION III-B Granada CD, 8:30 A.M.-10:OO A.M. ALCOHOL Jaime Frias, Chair 8:30-8~45

67 METHODOLOGIC PROBLEMS IN SURVEILLANCE OF FETAL ALCOHOL SYNDROME. Martin, M.L., A.B. McClearn, and M.J. Khoury*, CDC, Atlanta, Georgia

8:45-9:00

MOEBIUS SYNDROME ASSOCIATED WITH MATERNAL ALCO68 HOL ABUSE. Hall, B.D., Department of Pediatrics, University of Kentucky, Lexington, Kentucky

390

TERATOLOGY SOCIETY PROGRAM

9:00-9: 15

69 MATERNAL AND FETAL ALCOHOL METABOLIZING GENOTYPES IN FETAL ALCOHOL SYNDROME. Faustman, E.M., A.P. Streissguth, L.M. Stevenson*, G.S. Omenn*, and A. Yoshida*, Departments of Environmental Health, Medicine, and Psychiatry, University of Washington, Seattle, Washington, and Department of Biochem. Genetics, Beckman Research Institute, City of Hope, Duarte, California

9:15-9:30

70

9:30-9:45

71 FATTY ACID ETHYL ESTERS AND FETAL ALCOHOL SYNDROME. Bearer*, C.F., S. Gould*, S. Cho*, P.K. Kinnunen*, and C.S. Cook, Children’s Hospital Oakland Research Institute, Oakland, California, Department of Medicine, Washington University, St. Louis, Missouri and Department of Growth and Development, University of California San Francisco, San Francisco, California

9:45-10:00

72 PATHOGENETIC BASIS OF ETHANOL-INDUCED EXENCEPHALY AND ITS ASSOCIATION WITH MIDLINE FACIAL CLEFTS IN EARLY MOUSE EMBRYOS. Ketch*', L.E., W.S. Webster2, D.B. Dehart*’, and K.K. Sulik’, ‘Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill and 2Department of Anatomy, University of Sydney, Australia

10:00-10:30

BREAK

THE EFFECT OF DISULFIRAM ON THE UNBORN BABY. Jones, K.L., C.C. Chambers*, and K.A. Johnson*, Department of Pediatrics, University of California Medical Center, San Diego, California

PLATFORM SESSION IV-A Granada AB, 10:30 A.M.-12:OO NOON MECHANISMS OF DEVELOPMENTAL TOXICITY I Maureen Feuston, Chair 10:30-10:45

73 THE EFFECTS OF MERCURY INDUCED LAMININ AUTOANTIBODIES ON CULTURED RAT EMBRYOS. Chambers*, B.J., and N.W. Klein, Center for Environmental Health and Department of Animal Science, University of Connecticut, Storrs, Connecticut

10:45-11:00

74 DEPENDENCE OF EMBRYONIC LIMB CELL GROWTH ON pH. Bennett, G.D., W.C. Fischer, and W.J. Scott, Children’s Hospital Research Foundation, Cincinnati, Ohio

11:00-11:15

75 14C-DM0 COMPUTER ASSISTED IMAGING OF THE DEVELOPING MOUSE FORELIMB BUD EXPOSED TO ACETAZOLAMIDE. Schreiner*, C.M., W.J. Scott, M. Namovic*, and D. McCandless, Children’s Hospital Research Foundation, Cincinnati, Ohio and Chicago Medical School, North Chicago, Illinois

11:15-11:30

76 A ROLE FOR TGFPl and TGFP2 IN MURINE EMBRYONIC PALATE EPITHELIAL CELL DIFFERENTIATION. Gehris, A.L. and R.M. Greene, Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania

11:30-11:45

77 TGFP REGULATION OF TYPE I11 COLLAGEN PRODUCTION BY MESENCHYMAL CELLS OF THE DEVELOPING MURINE SECONDARY PALATE. D’Angelo, M. and R.M. Greene, Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania

TERATOLOGY SOCIETY PROGRAM

11:45-12:00

391

78 INTERACTIONS BETWEEN TGFp AND EGF IN INDUCTION OF SYNTHESIS OF SIGNALLING MOLECULES (PROSTAGLANDINS) BY MOUSE EMBRYO PALATE MESENCHYME CELLS. Chepenik, K.P., W.C. Franckle" and A. Diaz*, Departments of Anatomy and Rheumatology, Jefferson Medical College, Philadelphia, Pennsylvania

PLATFORM SESSION IV-B Granada CD,10:30 A.M.-12:OO NOON

ANTICONVULSANTS Jane Adams, Chair 10:30-10:45

79 THE TERATOGENIC EFFECT OF ANTICONVULSANTS ON POSTNATAL GROWTH. Raymond*, G.V. and L.B. Holmes, EmbryologyTeratology Unit, Massachusetts General Hospital, Boston, Massachusetts

10:45-11:00

80 DIGIT CHANGES: MOST COMMON FETAL EFFECT OF ANTICONVULSANTS (AC). Holmes, L.B., E.A. Harvey* and R.H. Cleveland*, Embryology-Teratology Unit, Children's Service and Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts

11:OO-ll:15

81 PREAXIAL RAY REDUCTION DEFECTS VALPROATE EXPOSURE DURING PREGNANCY. Graham, J.M., Jr., R. Sharony", A. Garber", R. Shreck*, L.D. Platt* and B.A. Buehler*, Meyer Institute University of Nebraska, Omaha, Nebraska and Medical Genetics Birth Defects Center, Cedars-Sinai Medical Center, Los Angeles, California

11115- 1:30

82 CLEFTING INDUCED BY PHENYTOIN IN ADRENALECTOMIZED MICE. Hansen, D.K., W.S. Branham, D.M. Sheehan, and R.R. Holson*, Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas

11:30- 1:45

83 QUANTITATIVE ELECTROENCEPHALOGRAPHY (EEG): A MARKER OF PRENATAL DRUG EXPOSURE. Livezey*, G.T., W.F. Rayburn*, and C.V. Smith, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha, Nebraska (Introduced by B.A. Buehler)

11:45-12:00

84 METHIONINE REDUCES THE FREQUENCY OF RESORPTIONS CAUSED BY SODIUM VALPROATE IN THE PREGNANT RAT. Nosel*, P.G., and N.W. Klein, Center for Environmental Health and Department of Animal Science, University of Connecticut, Storrs, Connecticut

12:00-1:30

PAST PRESIDENTS' LUNCHEON, Northeast Kingman (Tower)

1:30-3:30

WORKSHOPS/MINICOURSES (abstracts appear on pp. 412-415)

WORKSHOP I. IMAGING TECHNIQUES. David McCandless, Chicago Medical School, North Chicago, Illinois, Organizer-Mudrid 1-1 IMAGING TECHNIQUES IN DEVELOPMENTAL BIOLOGY AND TERATOLOGY. McCandless, J.W. and David McCandless, Chicago Medical School, North Chicago, Illinois 1-2APPLICATIONS OF 3-D IMAGE PROCESSING IN TERATOLOGY. Nahum D. Gershon*, The MITRE Corporation, McLean, Virginia (Introduced by J.M. DeSesso) MINICOURSE I. EMBRYOLOGICAL CONSIDERATIONS IN THE DEVELOPMENT OF CRANIO-FACIAL DEFECTS. Kathleen K. Sulik, University of North Carolina, Chapel Hill, North Carolina, Instructor-Grunadu AB

392

TERATOLOGY SOCIETY PROGRAM

MINICOURSE 11. DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY (DART) WORKSHOP. Stacey J. Arnesen", National Library of Medicine/NIH, Bethesda, Maryland, (Introduced by C.A. Kimmel) Instructor-Granada CD 3:30-3:45

BREAK

3:45-5:15 WORKSHOP 11. UNIQUE DEVELOPMENTAL SUSCEPTIBILITY: CASE STUDIESGranada AB 11-A. TRANSGENERATIONAL TERATOGENESIS AND CARCINOGENESIS. Robert W. Miller, National Cancer Institute, Bethesda, Maryland, Organizer 11-A-1 DOES PATERNAL EXPOSURE TO TOXIC AGENTS CAUSE CONGENITAL ANOMALIES? J a n M. Friedman, University of British Columbia, Vancouver, British Columbia, Canada 11-A-2 MULTIGENERATION TUMORIGENESIS STUDIES WITH RODENTS: EVIDENCE FOR IMPRINTING VS. STRUCTURAL GENE CHANGE. Lucy M. Anderson and Jerry M. Rice, National Cancer Institute, Frederick, Maryland 11-B. UNIQUE DEVELOPMENTAL SUSCEPTIBILITY-INFECTIOUS AGENTS. John L. Sever and John W. Larsen, Children's National Medical Center and George Washington University Medical Center, Washington, DC

WORKSHOP 111. MATERNAL AND CONCEPTAL (EXTRAEMBRYONIC) TISSUES IN NORMAL AND ABNORMAL DEVELOPMENT. Harpal S. Buttar, Organizer-Madrid 111-1 RAT FETAL MEMBRANES AND ASSOCIATED MATERNAL STRUCTURES: A PATHWAY FOR TERATOGENESIS? W.P. Jollie, Department of Anatomy, Medical College of Virginia and Virginia Commonwealth University, Richmond, Virginia NON HUMAN PRIMATE MODELS TO PERFECT NON IN111-2 VASIVE METHODS FOR TERATOLOGICAL, TOXICOLOGICAL AND VIROLOGICAL RESEARCH ON THE PLACENTA AND THE FETAL MEMBRANES. M. Panigel, Biology of Reproduction, University of Paris, Paris, France 111-3 CHEMICALLY-INDUCED ALTERATIONS IN MATERNAL HOMEOSTASIS AND CONCEPTAL HISTOLOGY: THEIR ETIOLOGIC SIGNIFICANCE IN RAT FETAL ANOMALIES. K.S. Khera, Bureau of Chemical Safety, Frederick Banting Research Centre, Ottawa, Ontario, Canada HUMAN PLACENTA AND ABNORMAL FETAL DEVEL111-4 OPMENT: THE CLINICAL EVIDENCE. C.M. Salafia, Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of Connecticut Health Center, Farmington, Connecticut

PLATFORM SESSION V Granada CD, 3:45 P.M.-5:15 P.M RETINOIDS Barbara D. Abbott, Chair 3:45-4:00

85 MICROINJECTION OF CULTURED RAT EMBRYOS: STUDIES WITH RETINOIDS. Creech Kraft, J.M., Q.P. Lee*, and M.R. Juchau, Department of Pharmacology, University of Washington, Seattle, Washington

TERATOLOGY SOCIETY PROGRAM

393

4:00-4:15

86 THE ROLE OF RETINYL PALMITATE IN VITAMIN A TERATOGENESIS. Ritchie", H.E., D.J. Oakes*, and W.S. Webster, Department of Anatomy, University of Sydney, Australia

4:15-4:30

87 EVALUATION OF THE TERATOGENIC POTENTIAL OF TOPICALLY APPLIED ALL-TRANS RETINOIC ACID (RA) IN MICE. Caldwell", A.P., and R.E. Seegmiller, Department of Zoology, Brigham Young University, Provo, Utah

4:30-4:45

88 IN VIVO HYDROLYSIS OF A RETINAMIDE TO RETINOIC ACID CONTRIBUTES TO TERATOGENICITY IN PREGNANT MICE. Penner", J.D., Y.F. Shealy*, and D.M. Kochhar, Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania and Southern Research Institute, Birmingham, Alabama

4:45-5:00

89 INCREASE IN TRANSGLUTAMINASE ACTIVITY IS CORRELATED WITH DYSMORPHOGENIC EVENTS INDUCED IN LIMB BUDS BY RETINOIC ACID. Jiang*, H., and D.M. Kochhar, Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania

5:00-5:15

90 PLACENTAL TRANSFER OF RETINOIDS FOLLOWING HIGHDOSE VITAMIN A DURING EARLY PREGNANCY IN THE MONKEY. Eckhoff"', C., J.R. Bailey*2, W. Slikker, Jr.2, and H. Naul, 'Institut fur Toxikologie und Embryonalpharmakologie, Freie Universitat Berlin, Germany, and 'Division of Reproductive and Developmental Toxicology, NCTR/FDA, Jefferson, Arkansas

CONTINUING EDUCATION COURSE Sponsored by the International Federation of Teratology Societies Barcelona, 1:OO P.M.- 5:OO P.M. COLLECTION AND INTERPRETATION OF DATA FROM DEVELOPMENTAL TOXICITY (TERATOLOGY) STUDIES"STATE OF THE A R T SCIENTIFIC REVIEW AND THE REALITIES OF THE REGULATORY SUBMISSION PROCESS Alan M. Hoberman, Narsingh D. Agnish, Granville A. Nolen Robert E. Staples and Charles V. Vorhees, Organizers Registration is required-contact Alexandra Ventura for information: (301) 571-1841 1:oo-1:10

WELCOME AND INTRODUCTORY REMARKS. Alan M. Hoberman, Argus Research Laboratories, Inc., Horsham, Pennsylvania

1:lO-2:oo

COLLECTION AND EVALUATION OF MATERNAL TOXICITY DATA. Rochelle Tyl, Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, North Carolina

2:00-2:50

COLLECTION AND EVALUATION OF DEVELOPMENTAL EMBRYOFETAL TOXICITY DATA. Frank Sullivan, Guy's Hospital Medical School, London, England

2:50-3:20

BREAK

3:20-4:10

COLLECTION AND EVALUATION OF POSTNATAL EFFECTS DATA. Elaine Z. Francis, Reproductive and Developmental Toxicology BranchiORD, US EPA, Washington, DC

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4:10-5:00

RELATIONSHIPS OF MATERNAL AND DEVELOPMENTAL TOXICITY DATA IN INTERPRETING DEVELOPMENTAL TOXICITY DATA. Mildred S. Christian, Argus Research Laboratories, Inc., Horsham, Pennsylvania

5:15-6145

TERATOLOGY SOCIETY BUSINESS MEETING-Great Hall South

7:30-10:30

THEME DINNER-Boca Beach Club

WEDNESDAY, JUNE 26 SYMPOSIUM IV Great Hall South, 8:OO A.M.-10:OOA.M NORMAL AND ABNORMAL PREIMPLANTATION EMBRYO DEVELOPMENT Joe C. Rutledge, Organizer and Chair 8:00-8:30

IV-1 DIFFERENTIATION AND FATE OF EARLY CELL LINEAGES IN MOUSE EMBRYOS. Roger A. Pedersen, Laboratory of Radiobiology and Environmental Health, University of California, San Francisco, California

8:30-9:00

IV-2 GENE UTILIZATION IN THE EARLY MAMMALIAN EMBRYO. Gilbert A. Schultz, Ann Hahnel, Andrew J. Watson and Aileen Hogan, Department of Medical Biochemistry, The University of Calgary, Calgary, Alberta, Canada

9:00-9:30

IV-3 GENOME IMPRINTING IN PEDIATRIC CANCERS. Carmen Sapienza, The Ludwig Institute for Cancer Research, Montreal, Canada

9:30-10:00

IV-4 CONGENITAL DEFECTS RESULTING FROM MUTAGEN TREATMENTS OF THE MOUSE ZYGOTE. Joe C. Rutledge and W.M. Generoso, University of Washington, Seattle, Washington and Oak Ridge National Laboratories, Oak Ridge, Tennessee

10:00-10:30

BREAK

PLATFORM SESSION VI-A Granada AB, 10:30 A.M.-12:OONOON MECHANISMS OF DEVELOPMENTAL TOXICITY I1 Michael D. Collins, Chair 10~30-10:45

SKELETAL DEVIATIONS IN MICE OFFSPRING FOLLOWING ZY91 GOTIC EXPOSURE TO ETHYLENE OXIDE. Polifka", J.E., J.C. Rutledge, G.L. Kimmel, V.V. Dellarco*, and W.M. Generoso*, Department of Pediatrics, University of Washington, Seattle, Washington; Laboratory Medicine, Children's Hospital and Medical Center, Seattle, Washington; EPA, Washington D.C.; and Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

10:45-11:00

92 EARLY EMBRYONIC SENSITIVITY TO CYCLOPHOSPHAMIDE IN LONG-TAILED MONKEYS (MACACA FASCICULARIS). Hendrickx, A.G., P.E. Peterson, J.R. Rowland*, and A.F. Tarantal, California Regional Primate Research Center, University of California, Davis, California

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11:00-11:15

93

EXENCEPHALIC MOUSE FETUSES ARE RESISTANT TO CLEFT PALATE INDUCTION WITH 2,3,7,8-TETRA-CHLORODIBENZO-p-D1OXIN (TCDD). Yasuda, M., T.J. Sato*, and H. Sumida", Department of Anatomy, Hiroshima University School of Medicine, Hiroshima, Japan

11:15-11:30

94

11:30-11:45

95

11:45-12:00

AN IN VITRO ASSESSMENT OF FETAL LUNG DIFFERENTIATION: SUPPORT FOR A THORACIC VOLUME REDUCTION MECHANISM FOR PULMONARY HYPOPLASIA IN CHONDRODYSTROPHIC MICE. Foster*, M.J., and R.E. Seegmiller, Department of Zoology, Brigham Young University, Provo, Utah

STAGE-DEPENDENT EFFECTS OF 2'-DEOXYCOFORMYCIN ON ADENOSINE AND 2'-DEOXYADENOSINE CATABOLISM IN THE MOUSE. Knudsen, T.B. and W.H. Dai*, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania TEMPORAL CHANGES IN ADENOSINE CONCENTRATION DURING EARLY POSTIMPLANTATION DEVELOPMENT IN THE MOUSE. Blackburn, M.R., X. Gao*, and T.B. Knudsen, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania 96

PLATFORM SESSION VI-B Granada CD, 10:30 A.M.-12:OO NOON SIDEDNESS AND ASYMMETRY Nigel Brown, Chair FURTHER STUDIES ON THE EMBRYONIC STAGE AT WHICH LEFTlRIGHT ASYMMETRY IS SPECIFIED IN RAT EMBRYOS. Brown, N.A., A. McCarthy*, and L. Wolpert*, MRC Experimental Embryology & Teratology Unit, St. George's Hospital Medical School and Department of Anatomy & Developmental Biology, University College & Middlesex Medical School, University of London, London, United Kingdom

10:30-10:45

97

10:45-11:00

PHARMACOLOGICAL EVIDENCE THAT STIMULATION OF RECEPTOR-MEDIATED ALPHA-1 ADRENERGIC PATHWAY IS INVOLVED IN THE CONTROL OF BODY ASYMMETRY. Fujinaga, M., M. Maze*, and J.M. Baden, Department of Anesthesia, Stanford University School of Medicine, Stanford, California and Palo Alto V.A. Medical Center, Palo Alto, California

11:00-11:15

99

11:15-11:30

100 LEGLESS, A MURINE GENE INVOLVED IN LIMB AND BRAIN DEVELOPMENT AND BODY ASYMMETRY. Supp*, D.M., G. Singh", J. McNeish*, W. Scott, H. Merker*, and S.S. Potter*, Children's Hospital Research Foundation, Cincinnati, Ohio

11:30-11:45

101 GENETIC INTERACTION IN THE RIGHT-LEFT TERATOGENIC GRADIENT FOR ACETAZOLAMIDE-INDUCED ECTRODACTYLY IN THE MOUSE. Biddle, F.G., L.R. Mulholland*, and B.A. Eales", Departments of Paediatrics and Medical Biochemistry, University of Calgary, Calgary, Alberta, Canada

98

SPONTANEOUS SITUS INVERSUS (SI) IN CULTURED POSTIMPLANTATION RAT EMBRYOS. Flynn, T.J. and R.R. Gibson*, Division of Toxicological Studies, Food and Drug Administration, Washington, DC.

396 11:45-12:00

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HYPOXIA AS A MAJOR MECHANISM OF COCAINE TERATO102 GENICITY. Carda*, M.R., R.W. Tumbic*, C.V. Barber*, and A.G. Fantel, Department of Pediatrics, University of Washington, Seattle, Washington

PLATFORM SESSION VI-C Madrid, 10:30 A.M.-12:OO NOON EPIDEMIOLOGY I1 J. David Erickson, Chair 10:30-10:45

103 CARDIOVASCULAR MALFORMATIONS IN WHITE AND BLACK INFANTS. Correa-Villaseiior", A., R. McCarter*, J. Downing*, C. Ferencz, and the Baltimore-Washington Infant Study (BWIS) Group, The Johns Hopkins Medical Institutions, Baltimore, Maryland

10:45-11:00

104 THE DESCRIPTIVE EPIDEMIOLOGY OF HYPOPLASTIC LEFT HEART, COARCTATION OF THE AORTA, AND AORTIC STENOSIS. Torfs", C.T., C.J. Curry, and J.A. Harris, California Birth Defects Monitoring Program, Emeryville, California

11:00-11:15

105 TEMPORAL TRENDS IN THE BIRTH PREVALENCE OF BIRTH DEFECTS IN THE UNITED STATES, 1979-1987. Edmonds*, L.D. and L.M. James, Centers for Disease Control, Atlanta, Georgia

11:15-11:30

106 MORTALITY AMONG INFANTS WITH BIRTH DEFECTS, METROPOLITAN ATLANTA, 1983-1989. Lynberg*, M.C., A.B. McClearn*, L.D. Edmonds*, and M.J. Khoury, Centers for Disease Control, Atlanta, Georgia.

11:30-11:45

107 A MULTIDISCIPLINARY APPROACH TO THE CLASSIFICATION OF BIRTH DEFECTS. Siebert, J.R., Department of Laboratories, Children's Hospital and Medical Center, and Department of Pathology, University of Washington, Seattle, Washington

11:45-12:00

ASCERTAINMENT OF EARLY FETAL LOSS IN RETROSPEC108 TIVE STUDIES. Selevan, S.G., Reproductive and Developmental Toxicology Branch/ORD, U.S. Environmental Protection Agency, Washington, DC.

POSTER SESSION I1 Camino Hall, 1:30 P.M.-4:00 P.M. (Posters should be set up after 12:OO noon on Tuesday and removed by midnight on Wednesday. Numbers P109-P137 should be attended from 1:30 P.M.-2:45 P.M. and Numbers P138-P166 and P185 attended from 2:45 P.M.-4:00 P.M.) Refreshments available P109 THE EPIDEMIOLOGY OF CARDIOVASCULAR MALFORMATIONS (CVM): TEN YEARS LATER. Ferencz, C., A. Correa-Villaseiior*, J.D. Rubin*, J.A. Boughman*, C. Loffredo and the Baltimore-Washington Infant Study (BWIS) Group, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland PllO ORGANIC SOLVENTS AND CARDIOVASCULAR MALFORMATIONS IN THE BALTIMORE-WASHINGTON INFANT STUDY. Loffredo*, C., C. Ferencz, A. Correa-Villaseiior* and the Baltimore-Washington Infant Study (BWIS) Group, Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland

TERATOLOGY SOCIETY PROGRAM

397

P l l l FIRST TRIMESTER SPONTANEOUS ABORTIONS ASSOCIATED WITH TRISOMIES 13, 18 AND 21: A PATHOLOGIC ANALYSIS OF 11 CASES. Honore, L.H., and C.C. Lin*, Department of Pathology, University of Alberta, Edmonton, Alberta, Canada P112 TETRAPLOIDY IN SPONTANEOUS ABORTION: A PATHOLOGIC STUDY OF 7 CASES. Honore, L.H., and C.C. Lin*, Department of Pathology, University of Alberta, Edmonton, Alberta, Canada P113 CEREBRAL VENTRICULOMEGALY IN FETUSES OF DIABETIC MOTHERS. Droste, S., D. Cyr* and Z. Brown*, Departments of Obstetrics and Gynecology and Radiology, University of Washington, Seattle, Washington P114 BIRTH DEFECTS IN THE OFFSPRING OF FEMALE WORKERS OCCUPATIONALLY EXPOSED TO CARBON DISULFIDE IN CHINA. Bao*, Y.-S., S. Cai*, S.F. Zhao*, X.C. Xhang*, M.Y. Huang*, 0. Zheng* and H. Jiang*', School of Public Health, Beijing Medical University, National Institute of Preventive Medicine, Beijing, P.R. China and 'Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania (Introduced by D.M. Kochhar) P115 DOSE-DEPENDENT EFFECTS OF FETAL DEXAMETHASONE EXPOSURE ON NEONATAL RENAL GROWTH AND FUNCTION IN THE RAT. Gray, J.A., F.J. Seidler* and T.A. Slotkin*, USEPA, Research Triangle Park, and Duke University Medical Center, Durham, North Carolina P116 BEHAVIORAL OUTCOMES IN AGED WISTAR RATS EXPOSED PRENATALLY TO X-IRRADIATION. Jensh, R.P., R.L. Brent, M.K. Till* and M.B. Eskesen", Departments of Anatomy, Pediatrics, and Radiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania P117 POSTNATAL GROWTH IN THE CD RAT FOLLOWING GESTATIONAL EXPOSURE TO DEXAMETHASONE (DEX). LaBorde, J.B., R.R. Holson", D.M. Sheehan and D.K. Hansen, Divison of Reproductive and Developmental Toxicology, National Center for Toxicological Research, Jefferson, Arkansas P118 PERINATAL AND POSTNATAL STUDY OF TAZOBACTAM ADMINISTERED INTRAPERITONEALLY TO CrL:CD@(SD)BR RATS ALONE OR IN COMBINATION WITH PIPERACILLIN. Lochry', E.A., A.M. Hoberman', R. Filler', W.J. Dougherty*' and C.E. Traitor*', 'Argus Research Laboratories, Inc, Horsham, Pennsylvania, and 2American Cyanamid Company, Pearl River, New York P119 DEVELOPMENTAL TOXICITY OF TAZOBACTAM ALONE AND IN COMBINATION WITH PIPERACILLIN IN MICE. Lochry', E.A., A.M. Hoberman', R. Filler', W.J. Dougherty*' and C.E. Traitor*', 'Argus Research Laboratories, Inc, Horsham, Pennsylvania, and 'American Cyanamid Company, Medical Reserch Division, Pearl River, New York P120 EMBRYO-FETAL TOXICITY AND TERATOGENIC POTENTIAL OF TAZOBACTAM ALONE AND IN COMBINATION WITH PIPERACILLIN RATS. Lochry', E.A., A.M. Hoberman', R. Filler', W.J. Dougherty"' and C.E. Traitor*', 'Argus Research Laboratories, Inc, Horsham, Pennsylvania, and 2American Cyanamid Company, Medical Reserch Division, Pearl River, New York P121 INTERACTION STUDY OF CHLORINATED ACETIC ACIDS IN PREGNANT LONGEVANS RATS. Smith, M.K., S.A. Christ*, J.L. Randall', G.A. Nolenl, E.J. Read*', and J.A. Stober*, HERL, USEPA, 'Computer Sciences Corporation, 'Pathology Associates, Inc, Cincinnati, Ohio P122 DEVELOPMENTAL EFFECTS OF 2-BROMOACETIC ACID IN THE LONG-EVANS RAT. Randall', J.L., S.A. Christ", P. Horton Perez', G.A. Nolen', E.J. Read*' and M.K. Smith,

398

TERATOLOGY SOCIETY PROGRAM

'Pathology Associates, Inc, HERL, USEPA, and 2Computer Sciences Corporation, Cincinnati, Ohio P123 DEVELOPMENTAL EFFECTS OF DICHLOROACETIC ACID IN LONG-EVANS RATS 11.ESTABLISHMENT OF NO ADVERSE EFFECT LEVEL. Randall', J.L., S.A. Christ*, G.A. Nolen', E.J. Read*2, and M.K. Smith, 'Pathology Associates, Inc, HERL, USEPA, and 'Computer Sciences Corporation, Cincinnati, Ohio P124 DEVELOPMENTAL TOXICITY STUDY OF METHYL ETHYL KETOXIME (MEKO) IN TWO SPECIES. Mercieca', M.D., W.E. Rinehart*2, J.R. H o d g ~ o n *and ~ M.J. Derelanko**, 'Springborn Laboratories, Inc, Spencerville, Ohio, 21ndustrial Health Foundation, Inc., Pittsburgh, Pennsylvania, 3Huls America Inc., Piscataway, New Jersey, and 4Allied-Signal Inc., Morristown, New Jersey P125 DEVELOPMENTAL TOXICITY STUDIES OF TRIBUTYL PHOSPHATE (TBP) IN THE RAT AND RABBIT. Schroeder, R.E., J.M. Gerhart and J. Kneiss*, Bio/dynamics Inc., East Millstone, New Jersey, AKZO Chemicals Inc., Chicago, IL, and Tributyl Phosphate Task Force, SOCMA, Washington, DC P126 IMPACT OF HOUSING AND HANDLING-RELATED STRESS ON THE OUTCOME OF INHALATION TERATOLOGY STUDIES. Ryan*, B.M., N.S. Hatourn", E. Mallett*, J.K. YermakofP and R.G. Farmer*, IIT Research Institute and Amoco Corporation, Chicago, Illinois (Introduced by J.M. Gerhart) P127 THE DEVELOPMENTAL TOXICITY OF INHALED GALLIUM ARSENIDE IN RODENTS. Mast, T.J., J.A. Dill*, B.J. Greenspan*, J.J. EvanofP, R.E. Morrissey' and B.A. Schwetz', Battelle-Pacific Northwest Laboratory, Richland, Washington, 'NIEHSNTP, Research Triangle Park, North Carolina P128 CARBON MONOXIDE MAY BE TERATOGENIC UNDER PROTEIN DEFICIENT CONDITIONS. Singh, J. and L. Moore-Cheaturn*, Stillman College, Tuscaloosa, Alabama P129 TERATOGENIC POTENTIAL OF FD&C YELLOW NO. 5 WHEN ADMINISTERED IN DRINKING WATER TO OSBORNE-MENDEL RATS. Collins, T.F.X., T.N. Black, M.J. ODonnell* and P. Bulhack*, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC P130 TERATOGENICITY STUDY IN RATS AND RABBITS ADMINISTERED IPAZILIDE ORALLY. Brown, G.L., W.A. Labarre*, M.M. Dennis, W.F. Blazak, Y. Greener and A.M. Ezrin, Sterling Research Group, Rensselaer, New York

(BAC) IN P131 DEVELOPMENTAL TOXICITY OF N,N-METHYLENEBISACRYLAMIDE MICE. George, J.D., C.J. Price, M.C. Marr, C.B. Myers, J.J. Heindel* and B.A. Schwetz, Research Triangle Institute and National Toxicology P r o g r d N I E H S , Research Triangle Park, North Carolina P132 DEVELOPMENTAL TOXICITY EVALUATION OF DEHP METABOLITES IN SWISS MICE. Price, C.J., R.W. Tyl, M.C. M a n , C.B. Myers, R.E. Morrissey, J.J. Heindel* and B.A. Schwetz, Research Triangle Institute and National Toxicology ProgramNIEHS, Research Triangle Park, North Carolina P133 DEVELOPMENTAL TOXICITY OF PEG-SOD ADMINISTERED INTRAVENOUSLY TO RATS AND RABBITS. Dennis, M.M., W.F. Blazak, Y. Greener and A.M. Hoberman, Sterling Research Group, Rensselaer, New York P134 ORAL ADMINISTRATION OF D-PENICILLAMINE TO CD-1 MICE CAUSES NEONATAL MORTALITY WITHOUT MORPHOLOGIC DEFECTS. MacNabb*, L.G., and

TERATOLOGY SOCIETY PROGRAM

399

C.G. Rousseaux, Department of Veterinary Pathology, WCVM, University of Saskatchewan, Saskatoon, Saskatchewan, Canada P135 DEVELOPMENTAL TOXICITY OF ZATOSETRON MALEATE. Byrd, R.A., D.M. Hoover*, and S.L. Kelich*, Toxicology Division, Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana P136 DEVELOPMENTAL TOXICITY OF LY237733. Kelich*, S.L., D.E. Seyler and R.A. Byrd, Toxicology Division, Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana P137 EMBRYOTOXICITY OF METHYLENE BLUE IN THE RAT. Piersma, A.H., A. Verhoer', A. De Liefde*, B.P.M. Van Nesselrooij" and J.M. Garbis-Berkvens*, Unit Teratology, Endocrinology and Perinatal Screening, RIVM, Bilthoven, The Netherlands P138 THE EFFECTS OF LOCAL AND GENERAL APPLICATION OF PROTAMINE TO CHICK EMBRYOS. Stephens, T.D., Department of Biological Sciences, Idaho State University, Pocatello, Idaho P139 RESPONSES OF PRECHONDROGENIC CELLS FROM CHICK AND RAT EMBRYOS TO 8 TEST COMPOUNDS. Wiger*', R., and N.A. Brown2, 'Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway and 2MRC Experimental Embryology and Teratology, St. George's Hospital Medical School, London, United Kingdom P140 THE EFFECTS OF ANTI-TUBULIN AGENTS ON RAT EMBRYONIC MIDBRAIN (CNS) CELL CULTURES. Whittaker*, S.G., and E.M. Faustman, Departments of Pathology and Environmental Health, University of Washington, Seattle, Washington P141 SERA TERATOGENICITY TO CULTURED RAT EMBRYOS IN WOMEN WITH HISTORIES OF SPONTANEOUS ABORTION. Ferrari*, D.A., P.A. Gilles* and N.W. Klein, Center for Environmental Health and Department of Animal Science, University of Connecticut, Storrs, and CIBA-GEIGY, Farmington, Connecticut P142 THE EFFECTS OF SERA FROM WOMEN WITH RECURRENT SPONTANEOUS ABORTIONS ON THE DEVELOPMENT OF EARLY SOMITE RAT EMBRYOS IN VITRO. Abir, R., H. Ben Hur, H. Pinus, P. Jaffe and A. Ornoy, Laboratory of Teratology, Hebrew University, Hadassah Medical School, Jerusalem, Israel. P143 VARIATION IN DEVELOPMENT OF RAT EMBRYOS AT THE PRESOMITE PERIOD. Fujinaga, M., and J.M. Baden, Department of Anesthesia, Stanford University School of Medicine, Stanford, and Palo Alto V.A. Medical Center, Palo Alto, California P144 THE USE OF RAT WHOLE EMBRYO CULTURE FOR THE PREDICTION OF TERATOGENIC HAZARD: IN VIVO/IN VITRO CORRELATIONS. Tesh, J.M., F.W. Ross and H.C. Bowden, Life Science Research Ltd., Eye, Suffolk, England P145 EMBRYOTOXIC EFFECTS OF METHANOL IN WHOLE EMBRYO CULTURE. Andrews, J.E., M. Ebron-McCoy* and J.M. Rogers, Developmental Toxicology Division, US EPA, Research Triangle Park, North Carolina P146 A NEW PROCEDURE FOR SERUM-FREE PALATAL ORGAN CULTURE. Buckalew*, A.R., and B.D. Abbott, ManTech Environmental Technology, Inc., and US EPA, Research Triangle Park, North Carolina P147 RESPONSES OF EMBRYONIC PALATES TO SELECTED TERATOGENS IN SERUM-FREE ORGAN CULTURE. B.D. Abbott, Developmental Toxicology Division, HERL, US EPA, Research Triangle Park, North Carolina

400

TERATOLOGY SOCIETY PROGRAM

P148 DEVELOPMENTAL TOXICITY OF NON-DEPOLARIZING MUSCLE RELAXANTS IN CULTURED RAT EMBRYOS. Fujinaga, M., J.M. Baden and R.I. Mazze, Department of Anesthesia, Stanford University School of Medicine, Stanford, and Palo Alto V.A. Medical Center, Palo Alto, California P149 EFFECTS OF A TERATOGEN, VINBLASTINE, ON CELLULAR PROTEINS IN AN EMBRYONIC CELL LINE. Weng*', J.L., B.W. Kemppainen*l, D. Stringfellow*', R. Paxton"' and S. Price*', 'Department of Physiology and Pharmacology, and 'Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, Alabama (Introduced by R.D. Hood) P150 THE DEVELOPMENTAL TOXICITY HAZARD POTENTIAL OF THALIDOMIDE EVALUATED IN HYDRA WITH AND WIHTOUT MFO ACTIVATION. Newman, L.M., E.M. Johnson, R. Giacobbe* and R.-W. Zhang*, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania P151 METABOLISM OF ETHYLENE GLYCOL ETHERS IN HYDRA AS IT RELATES TO EXPRESSED TOXICITY. Wang", Y.-H., J. Potochny*, L.M. Newman, E.M. Johnson, R. Giacobbe and R.-W. Zhang*, Department of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania P152 FACTORS IN PHENYLKETONURIA: DEVELOPMENTAL ABNORMALITIES CAUSED BY PHENYLETHYLAMINE. Denno, K.M., Xia Ping He and T.W. Sadler, Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill, North Carolina P153 FLOW CYTOMETRIC ANALYSIS OF MURINE ERYTHROLEUKEMIC CELL (MELC) TOXICITY AS AN IN VITRO MECHANISTIC MODEL OF DEVELOPMENTAL TOXICITY. Zucker*, R.M., K.H. Elstein*, E.J. Massaro, N. Chernoff and J.M. Rogers, ManTech Environmental Technology, Inc., and US EPA, Health Effects Research Laboratory, Research Triangle Park, North Carolina P154 PROSTAGLANDIN SYNTHESIS BY CBAIJ MURINE FETAL THYMIC LOBES. Pendino*, K.J., and R.R. Schmidt*, Department of Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania (Introduced by K.P. Chepenik) P155 ULTRASTRUCTURAL MORPHOMETRIC ANALYSIS OF HUMAN CELLULAR TROPHOBLASTS CULTURED ON A FIBRIN SUBSTRATE. Farmer, D.R., and D.M. Nelson*, Department of OB/GYN, Washington University School of Medicine, St. Louis, Missouri P156 HUMAN EMBRYONIC CYTOCHROME P450s: PROBES WITH PHENOXAZONE ETHERS AND 0-DEALKYLASE/DEBENZYLASE INHIBITORS. Lee*, Q.P., and M.R. Juchau, Department of Pharmacology, University of Washington, Seattle, Washington P157 THE ASSOCIATION OF HEAT-INDUCED ALTERATIONS IN PROTEIN SYNTHESIS WITH SOMITE DEFECTS IN RAT EMBRYOS. Fisher', B.R., G.L. Kimmel', C.A. Kimmel' and D.J. Heredia*3, 'Center for Devices and Radiological Health, FDA, and 3Biocon, Inc., Rockville, Maryland, and 'Reproductive and Developmental Toxicology BrancUORD, US EPA, Washington, DC P158 STRESS PROTEIN SYNTHESIS AS A POTENTIAL BIOMARKER FOR HEAT-INDUCED DEVELOPMENTAL TOXICITY. Kimmel', C.A., G.L. Kimmel', C. Lu*', D.J. Heredia*3, B.R. Fisher' and N.T. Brown*', 'Reproductive and Developmental Toxicology BrancUORD, US EPA, Washington, DC, 'Center for Devices and Radiological Health, FDA, and 3Biocon, Inc., Rockville, Maryland

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401

P159 STRAIN DIFFERENCES IN HEAT-INDUCED TOLERANCE TO CADMIUM IN MOUSE EMBRYOS IN VITRO. Kapron-Bras, C.M., and B.F. Hales, Centre for the Study of Reproduction, McGill University, Montreal, Canada P160 ASSOCIATION OF STRESS PROTEIN SYNTHESIS WITH TERATOGENESIS IN RETINOIC ACID-TREATED RODENT TISSUE. Anson, J.F., J.B. LaBorde, J.L. Pipkin*, D.K. Hansen, W.G. Hinson*, D.M. Sheehan and J.F. Young, Divisions of Research, Information and Management Services, Reproductive and Developmental Toxicology and Genetic Toxicology, National Center for Toxicological Research, Jefferson, Arkansas P161 EFFECTS OF SMOKELESS TOBACCO AND ETHANOL ON SKELETAL OSSIFICATION IN THE MOUSE. Paulson, R., J. Shanfeld", J. Dean*, J. Paulson* and R. Bales*, Department of Oral Biology, OSU and Ohio Department of Health, Columbus, Ohio P162 DISTRIBUTION OF MORPHOLOGIC EFFECTS IN RATS EXPOSED TO 35% ETHANOL. Rodier, P.M., B. Kates and L. Gerken, Department of Obstetrics and Gynecology, University of Rochester, Rochester, New York P163 CARDIOVASCULAR DEVELOPMENT (CVD) IN F-344 RATS FOLLOWING PHASESPECIFIC EXPOSURE TO 2-BUTOXYETHANOL (BE). Sleet*, R.B., C.J. Price, M.C. Marr, R.M. Morrissey and B.A. Schwetz, Research Triangle Institute and NTP, NIEHS, Research Triangle Park, North Carolina Pl64 METHANOL TERATOGENICITY IN PREGNANT LONG EVANS RATS. Yousser", A.F., R.B. Baggs, B. Weiss", and R.K. Miller, Environmental Health Sciences Center, Departments of Biophysics and Obstetrics/Gynecology, University of Rochester Medical Center, Rochester, New York and Department of Forensic Medicine and Toxicology, Cairo University, Cairo, Egypt P165 DEVELOPMENTAL EFFECTS OF COMBINED EXPOSURES TO ETHANOL AND VITAMIN A. Whitby, K.E.', T.F.X. Collins, J.J. Welsh, T.N. Black, T.J. Flynn, M. Schackelford*, S.E. Ware", J.I. Rorie, N. Gregory* and M.I. ODonnell", 'Office of Pesticide Programs, U.S. Environmental Protection Agency, Washington, DC and Divisions of Toxicology, Administrative Drug Administration, Washington, DC P166 VARIABLE POLYNUCLEAR AROMATIC HYDROCARBON (PAH) METABOLIC POTENTIAL IN TERM HUMAN PLACENTAS EXPOSED TO CIGARETTE SMOKE DURING GESTATION. Sanyal*, M.K., Y.L. Li*, C.B.M. Oudejans*, and W.J. McMurray", Department of Obstetrics and Gynecology and Yale Comprehensive Cancer Center, Yale University Medical School, New Haven Connecticut P185 TERATOGENIC EFFECTS IN RAT OF ICI 199,456, A THROMBOXANE RECEPTOR ANTAGONIST. Freeman, S.J., S.J. Evans*, V.J. Martin*, and R.A. Siddall*, ICI Pharmaceuticals, Alderley Park, Macclesfield, SKlO 4TG, United Kingdom

POSTER DISCUSSION SESSION II-A Granada AB, 4:OO P.M.-5:00 P.M. EPIDEMIOLOGY/CLINICAL TERATOLOGY Jose Cordero, Chair P109 THE EPIDEMIOLOGY OF CARDIOVASCULAR MALFORMATIONS (CVM): TEN YEARS LATER. Ferencz et al. PllO ORGANIC SOLVENTS AND CARDIOVASCULAR MALFORMATIONS IN THE BALTIMORE-WASHINGTON INFANT STUDY. Loffredo et al. P111 FIRST TRIMESTER SPONTANEOUS ABORTIONS ASSOCIATED WITH TRISOMIES 13, 18 AND 21: A PATHOLOGIC ANALYSIS OF 11CASES. Honor6 and Lin

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P112 TETRAPLOIDY IN SPONTANEOUS ABORTION: A PATHOLOGIC STUDY OF 7 CASES. Honore and Lin P113 CEREBRAL VENTRICULOMEGALY IN FETUSES OF DIABETIC MOTHERS. Droste et al. P114 BIRTH DEFECTS IN THE OFFSPRING OF FEMALE WORKERS OCCUPATIONALLY EXPOSED TO CARBON DISULFIDE IN CHINA. Bao et al.

POSTER DISCUSSION SESSION 11-B Granada CD, 4:OO P.M.-5:00 P.M. IN VITRO Norman Klein, Chair P140 THE EFFECTS OF ANTI-TUBULIN AGENTS ON RAT EMBRYONIC MIDBRAIN (CNS) CELL CULTURES. Whittaker and Faustman P141 SERA TERATOGENICITY TO CULTURED RAT EMBRYOS IN WOMEN WITH HISTORIES OF SPONTANEOUS ABORTION. Ferrari et al. P142 THE EFFECTS OF SERA FROM WOMEN WITH RECURRENT SPONTANEOUS ABORTIONS ON THE DEVELOPMENT OF EARLY SOMITE RAT EMBRYOS IN VITRO. Abir et al. P143 VARIATION IN DEVELOPMENT OF RAT EMBRYOS AT THE PRESOMITE PERIOD. Fujinaga and Baden P144 THE USE OF RAT WHOLE EMBRYO CULTURE FOR THE PREDICTION OF TERATOGENIC HAZARD: IN VIVO/IN VITRO CORRELATIONS. Tesh et al. P145 EMBRYOTOXIC EFFECTS OF METHANOL IN WHOLE EMBRYO CULTURE. Andrews et al. P146 A NEW PROCEDURE FOR SERUM-FREE PALATAL ORGAN CULTURE. Buckalew and Abbott P147 RESPONSES OF EMBRYONIC PALATES TO SELECTED TERATOGENS IN SERUM-FREE ORGAN CULTURE. Abbott

POSTER DISCUSSION SESSION 11-C Madrid, 4:OO P.M.-5:00 P.M. HEAT SHOCK/STRESS PROTEINS Philip Mirkes, Chair P157 THE ASSOCIATION OF HEAT-INDUCED ALTERATIONS IN PROTEIN SYNTHESIS WITH SOMITE DEFECTS IN RAT EMBRYOS. Fisher et al. P158 STRESS PROTEIN SYNTHESIS AS A POTENTIAL BIOMARKER FOR HEAT-INDUCED DEVELOPMENTAL TOXICITY. Kimmel et al. P159 STRAIN DIFFERENCES IN HEAT-INDUCED TOLERANCE TO CADMIUM IN MOUSE EMBRYOS IN VITRO. Kapron-Bras and Hales

TERATOLOGY SOCIETY PROGRAM

403

P160 ASSOCIATION OF STRESS PROTEIN SYNTHESIS WITH TERATOGENESIS IN RETINOIC ACID-TREATED RODENT TISSUE. Anson et al.

6:30-7:30

RECEPTION-Gurden Pool

7:30-1O:OO

BANQUET-Greut Hull South

THURSDAY, JUNE 27 SYMPOSIUM V WHERE IS THE WAR TO PREVENT BIRTH DEFECTS? Great Hall South, 8:OO A.M.- 1O:OO A.M. Sponsored by the Public Affairs Committee of the Teratology Society 8:OO-8:lO

INTRODUCTION. Godfrey P. Oakley, Jr., Director, Division of Birth Defects and Developmental Disabilities, Centers for Disease, Control, Atlanta, Georgia

8:10-8:40

THE MAGNITUDE OF THE HUMAN BIRTH DEFECTS PROBLEM. John Harris, Chief, California Birth Defects Monitoring Program, Department of Health Services, Emeryville, California

8:40-9:10

WHY IS THE PREVENTION OF BIRTH DEFECTS NOT A VERY HIGH NATIONAL PRIORITY? Lewis B. Holmes, Chief, Embryology-Teratology Unit, Massachusetts General Hospital, Boston, Massachusetts

9:10-9:40

WHAT MUST HAPPEN IF THE PREVENTION OF BIRTH DEFECTS IS TO BECOME A HIGHER NATIONAL PRIORITY. Elaine Z. Francis, Legislative Fellow, Office of Senator Joseph Lieberman, and James W. Hanson, Kennedy Foundation Fellow, Office of Senator Tom Harkin, Washington, DC

9:40-1O:OO

DISCUSSION

10:00-10:30

BREAK

PLATFORM SESSION VII-A Granada AB, 10:30 A.M.-12:OONOON NUTRITIONAL FACTORS Carl L. Keen, Chair 10:30-10:45

167 CULTURED ORGANOGENESIS-STAGED RAT EMBRYOS AS BIOMARKERS FOR NUTRITIONAL FACTORS IN HUMAN REPRODUCTIVE FAILURE. Flynn, T.J., A.R. Scialli, and R.R. Gibson*, Division of Toxicological Studies, Food and Drug Administration, and Department of Obstetrics and Gynecology, Georgetown University School of Medicine, Washington, DC

10:45-11:OO

168 EFFECTS OF COPPER NUTRITION ON DIABETIC PREGNANCY OUTCOME IN RATS. Jankowski, M.A.", J.Y. Uriu-Hare", R.B. Rucker", and C.L. Keen, Department of Nutrition, University of California, Davis, California

11:00-11:15

169 THE INFLUENCE OF MATERNAL ZINC DEFICIENCY ON MOUSE PREIMPLANTATION DEVELOPMENT IN VITRO AND 3-H-GLYCINE UPTAKE BY UNFERTILIZED OOCYTES AND EARLY EMBRYOS.

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Peters*, J.M., L.M. Wiley*, S. Zidenberg-Cherr*, and C.L. Keen, Departments of Nutrition and Ob/Gyn, University of California, Davis, California 11:15-11:30

170 ALTERED MATERNAL Zn STATUS BY a-HEDERIN AND ADVERSE DEVELOPMENTAL OUTCOME IN RATS. Daston, G.P., G.J. Overmann", D. Baines*, M.W. Taubeneck*, L.D. Lehman-McKeeman*, J.M. Rogers, and C.L. Keen, Procter 8z Gamble, Cincinnati, Ohio, University of California, Davis, California, and U.S. EPA, Research Triangle Park, North Carolina

11:30-11:45

171 EVIDENCE FOR A COMMON PATHWAY OF DEVELOPMENTAL TOXICITY OF URETHANE, MELPHALAN AND ARSENIC: IMPACT ON MATERNAL AND EMBRYONIC ZINC STATUS. Taubeneck*, M.W., G.P. Daston, J.M. Rogers, and C.L. Keen, University of California at Davis, Davis, California, Procter and Gamble, Cincinnati, Ohio, and U.S. EPA, Research Triangle Park, North Carolina

11:45-12:OO

172 CELL DEATH AND CELL CYCLE DISTRIBUTIONS IN RAT EMBRYOS FOLLOWING VARYING LENGTHS OF ZINC DEFICIENCY: NEURAL CREST CELLS ARE KILLED BY SHORT-TERM DEFICIENCY. Rogers, J.M., K.K. Sulik, M.W. Taubeneck, R.M. Zucker*, K.H. Elstein*, and C.L. Keen, U.S. EPA, Developmental Toxicology Division and ManTech, Research Triangle Park, and University of North Carolina, Chapel Hill, North Carolina and University of California, Davis, California

PLATFORM SESSION VII-B Granada CD, 10:30 A.M.-12:OO NOON HAZARD/RISK EVALUATION Gary L. Kimmel, Chair 10:30-10:45

173 ADDITIVE MALFORMATION RATE FOR A MIXTURE OF TEN ALIPHATIC ACIDS. Dawson, D.A., University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee

10:45-11:00

174 DEVELOPMENTAL TOXICITY OF CLARIFIED SLURRY OIL, DISTILLATE AROMATIC EXTRACT AND SYNTOWER BOTTOMS ADMINISTERED AS A SINGLE ORAL DOSE TO PREGNANT RATS. Feuston, M.H., S.L. Kerstetter, K.R. Bodnar and P.D. Wilson, Mobil Oil Corporation, Princeton, New Jersey

11:00-11:15

175 PRIORITIZATION OF CANDIDATE REPRODUCTIVE/DEVELOPMENTAL TOXICANTS FOR EVALUATION UNDER CALIFORNIA'S PROPOSITION 65. Donald, J.M., L.E. Monserrat, K. Hooper, S.A. Book, and G.F. Chernoff, California Department of Health Services, Health Hazard Assessment Division, Sacramento, California

11:15-11:30

176 A PROPOSED MULTI-SUBSTANCE RULE FOR THE TESTING OF POTENTIAL DEVELOPMENTAL AND REPRODUCTIVE TOXICANTS UNDER THE TOXIC SUBSTANCES CONTROL ACT (TSCA). Francis, E.Z., Reproductive and Developmental Toxicology Branch/OHEA, U S . Environmental Protection Agency, Washington, DC 177 META-ANALYSIS IN CLINICAL TERATOLOGY: MATERNAL CIGARETTE SMOKING AND ORAL CLEFTING. Hartsfield, Jr., J.K., and T.C. Hudson*, Department of Pediatrics, University of South Florida, Tampa, Florida

TERATOLOGY SOCIETY PROGRAM 11:45-12:00

405

178 CHANGING PERCEPTION OF REPRODUCTIVE AND GENETIC RISKS IN PATIENTS WITH PRIOR RADIATION AND CANCER CHEMICAL THERAPY. Brent, R.L., Department of Pediatrics, Jefferson Medical College, Philadelphia, Pennsylvania and A.I. duPont Institute, Wilmington, Delaware

PLATFORM SESSION VII-C Madrid, 10:30 A.M.-12:OO NOON NEURAL TUBE Thomas W. Sadler, Chair 10:30-10:45

179 FIRST TRIMESTER ANESTHESIA EXPOSURE AND RISK OF CENTRAL NERVOUS SYSTEM DEFECTS: A POPULATION-BASED CASECONTROL STUDY. Sylvester*, G.C., M.J. Khoury, X. Lu, and J.D. Erickson, Centers for Disease Control, Atlanta, Georgia

10:45-11:00

180 THE RELATIONSHIPS OF THE SPINAL CORD AND MENINGES IN MENINGOCELE, MENINGOMYELOCELE, AND INIENCEPHALY. Jordan*, M.A., D.S. Heffez*, and G.M. Hutchins, The Johns Hopkins Medical Institutions, Baltimore, Maryland

11:OO-ll:15

181 ONTOGENESIS OF NEURON-DIFFERENTIATION POTENTIAL DURING ORGANOGENESIS OF THE RAT EMBRYO. Sanyal*, M.K., W.J. Biggem*,. Y.L. Li*, C.B.M. Oudejans*, and M. Garcia-Segura", Department of Obstetrics and Gynecology, Yale University Medical School, New Haven, Connecticut

11:15-11:30

182 PATTERNS OF PURKINJE CELL LOSS IN THE VERMAL CEREBELLUM AFTER POSTNATAL ETHANOL ADMINISTRATION. Hamre*, K.M., and J.R. West, Department of Anatomy, University of Iowa, Iowa City, Iowa

11:30-11:45

183 APPLICATION OF IN SITU TRANSCRIPTION AND aRNA AMPLIFICATION TO THE STUDY OF MURINE NEURAL TUBE DEFECTS. Finnell, R.H., and J.H. Eberwine*, College of Veterinary Medicine, Washington State University, Pullman, Washington and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

11:45-12:00

184 IMMUNOFLUORESCENT LOCALIZATION OF CHONDROITIN (CSPG) AND HEPARAN SULPHATE PROTEOGLYCANS (HSPG) IN PRESPINA BIFIDA SPLOTCH MOUSE EMBRYOS. Trader', D.G., and G. Morriss-Kay*, Department of Biology and Centre for Human Genetics, McGill University, Montreal, Canada' and Department of Human Anatomy, Oxford, United Kingdom

12:00-1:30

COUNCIL I1 MEETING-Vidul

Room, (Tower)

The Teratology Society thirty-first annual meeting, June 22-27, 1991 and the International Federation of Teratology Societies third meeting, June 24-25, 1991. Boca Raton, Florida. Program, abstracts.

TERATOLOGY 43: 371-408 (1991) THE TERATOLOGY SOCIETY TH IRTY-FIRST ANNUAL MEETING JUNE 22-27, 1991 AND THE INTERNAT ONAL FEDERAT ON OF TERATOLOGY SO...
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