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JCP Online First, published on July 2, 2014 as 10.1136/jclinpath-2014-202243 Original article
The syndrome of inappropriate antidiuresis is associated with excess long-term mortality: a retrospective cohort analyses Ansu Basu,1,2 Robert E J Ryder1 ▸ Additional material is published online only. To view please visit the journal online (http://dx.doi.org/10.1136/ jclinpath-2014-202243). 1
Department of Diabetes, Endocrinology and Lipid Metabolism, City Hospital, Birmingham, UK 2 The University of Birmingham, College of Medical and Dental Sciences, Birmingham, UK Correspondence to Dr Ansu Basu, Department of Diabetes, Endocrinology and Lipid Metabolism, City Hospital, Dudley Road, Birmingham B18 7QH UK; [email protected] Received 2 March 2014 Revised 22 May 2014 Accepted 7 June 2014
ABSTRACT Introduction The syndrome of inappropriate antidiuresis (SIAD) is the commonest cause of euvolaemic hyponatraemia in patients admitted to hospital. The mortality after discharge from hospital has not been previously studied in patients with SIAD. Aims To compare mortality in patients with SIAD and those with kidney injury (KI). To identify underlying diagnoses associated with deaths due to SIAD. Methods Single-centre retrospective cohort analyses of 804 patients with severe hyponatraemia over a 3-year period. Five-year survival data in patients with SIAD and those with KI were compared. The underlying diagnoses that contributed to SIAD in this cohort were analysed using ICD-10 codes. Results 202 patients had SIAD using biochemical cutoff parameters; 248 patients had KI. Patient with KI had a statistically significant (log-rank p
JCP Online First, published on July 2, 2014 as 10.1136/jclinpath-2014-202243 Original article
The syndrome of inappropriate antidiuresis is associated with excess long-term mortality: a retrospective cohort analyses Ansu Basu,1,2 Robert E J Ryder1 ▸ Additional material is published online only. To view please visit the journal online (http://dx.doi.org/10.1136/ jclinpath-2014-202243). 1
Department of Diabetes, Endocrinology and Lipid Metabolism, City Hospital, Birmingham, UK 2 The University of Birmingham, College of Medical and Dental Sciences, Birmingham, UK Correspondence to Dr Ansu Basu, Department of Diabetes, Endocrinology and Lipid Metabolism, City Hospital, Dudley Road, Birmingham B18 7QH UK; [email protected] Received 2 March 2014 Revised 22 May 2014 Accepted 7 June 2014
ABSTRACT Introduction The syndrome of inappropriate antidiuresis (SIAD) is the commonest cause of euvolaemic hyponatraemia in patients admitted to hospital. The mortality after discharge from hospital has not been previously studied in patients with SIAD. Aims To compare mortality in patients with SIAD and those with kidney injury (KI). To identify underlying diagnoses associated with deaths due to SIAD. Methods Single-centre retrospective cohort analyses of 804 patients with severe hyponatraemia over a 3-year period. Five-year survival data in patients with SIAD and those with KI were compared. The underlying diagnoses that contributed to SIAD in this cohort were analysed using ICD-10 codes. Results 202 patients had SIAD using biochemical cutoff parameters; 248 patients had KI. Patient with KI had a statistically significant (log-rank p
