HHS Public Access Author manuscript Author Manuscript
J Sleep Med Disord. Author manuscript; available in PMC 2016 February 17. Published in final edited form as: J Sleep Med Disord. 2015 ; 2(4): .
The Relationship between Metformin and Obstructive Sleep Apnea Deborah Lin1,*, Lisa Rein2, Sergey Tarima2, B. Tucker Woodson3, and John R. Meurer4 1Clinical 2Division
and Translational Science Institute, Medical College of Wisconsin (MCW), USA of Biostatistics, Institute for Health and Society, USA
Author Manuscript
3Department 4Division
of Otolaryngology, MCW, USA
of Population Health Improvement, Institute for Health and Society, USA
Abstract Objectives—This study aimed to assess if metformin had any associations with the prevalence of obstructive sleep apnea in an adult type 2 diabetes population in the Midwest. Hypothesis—Use of metformin is associated with decreased prevalence of obstructive sleep apnea in a adult type 2 diabetes population.
Author Manuscript
Methods—A retrospective secondary database analysis was carried out with metformin use by patients with type 2 diabetes as the primary variable of interest and obstructive sleep apnea status as the primary outcome. A sample population of 9,853 type 2 diabetes patients with one year of follow-up was used. Other variables that were analyzed included age, gender, race, hypertension, Congestive Heart Failure, Hemoglobin A1c (HbA1c), and Body Mass Index. A p-value of
J Sleep Med Disord. Author manuscript; available in PMC 2016 February 17. Published in final edited form as: J Sleep Med Disord. 2015 ; 2(4): .
The Relationship between Metformin and Obstructive Sleep Apnea Deborah Lin1,*, Lisa Rein2, Sergey Tarima2, B. Tucker Woodson3, and John R. Meurer4 1Clinical 2Division
and Translational Science Institute, Medical College of Wisconsin (MCW), USA of Biostatistics, Institute for Health and Society, USA
Author Manuscript
3Department 4Division
of Otolaryngology, MCW, USA
of Population Health Improvement, Institute for Health and Society, USA
Abstract Objectives—This study aimed to assess if metformin had any associations with the prevalence of obstructive sleep apnea in an adult type 2 diabetes population in the Midwest. Hypothesis—Use of metformin is associated with decreased prevalence of obstructive sleep apnea in a adult type 2 diabetes population.
Author Manuscript
Methods—A retrospective secondary database analysis was carried out with metformin use by patients with type 2 diabetes as the primary variable of interest and obstructive sleep apnea status as the primary outcome. A sample population of 9,853 type 2 diabetes patients with one year of follow-up was used. Other variables that were analyzed included age, gender, race, hypertension, Congestive Heart Failure, Hemoglobin A1c (HbA1c), and Body Mass Index. A p-value of
