Biol Trace Elem Res (2014) 158:219–223 DOI 10.1007/s12011-014-9925-7
The Protective Effect of Vanadium Against Diabetic Cataracts in Diabetic Rat Model Lei Sun & De-Jing Shi & Xiang-Chun Gao & Shu-Yong Mi & Ying Yu & Qing Han
Received: 25 January 2014 / Accepted: 24 February 2014 / Published online: 8 March 2014 # Springer Science+Business Media New York 2014
Abstract The present study was designed to investigate the effect of vanadium in alloxan-induced diabetes and cataract in rats. Different doses of vanadium was administered once daily for 8 weeks to alloxan-induced diabetic rats. To know the mechanism of action of vanadium, lens malondialdehyde (MDA), protein carbonyl content, activity of superoxide dismutase (SOD), activities of aldose reductase (AR), and sorbitol levels were assayed, respectively. Supplementation of vanadium to alloxan-induced diabetic rats decreased the blood glucose levels due to hyperglycemia, inhibited the AR activity, and delayed cataract progression in a dose-dependent manner. The observed beneficial effects may be attributed to polyol pathway activation but not decreased oxidative stress. Overall, the results of this study demonstrate that vanadium could effectively reduce the alloxan-induced hyperglycemia and diabetic cataracts in rats. Keywords Vanadium . Diabetes . Blood glucose . Cataract
Introduction Diabetes recently has reached almost epidemic levels worldwide. Diabetic cataract is one of the earliest secondary complications of diabetes, and it is characterized by opacification of the eye lens [1]. Approximately 42 % of the world’s blindness can be attributed to diabetic cataracts [2]. Diabetes-associated cataractogenesis is well known to be initiated by osmotic stress caused by the intralenticular accumulation of polyols produced by the polyol pathway [3, 4]. In L. Sun : D.
The Protective Effect of Vanadium Against Diabetic Cataracts in Diabetic Rat Model Lei Sun & De-Jing Shi & Xiang-Chun Gao & Shu-Yong Mi & Ying Yu & Qing Han
Received: 25 January 2014 / Accepted: 24 February 2014 / Published online: 8 March 2014 # Springer Science+Business Media New York 2014
Abstract The present study was designed to investigate the effect of vanadium in alloxan-induced diabetes and cataract in rats. Different doses of vanadium was administered once daily for 8 weeks to alloxan-induced diabetic rats. To know the mechanism of action of vanadium, lens malondialdehyde (MDA), protein carbonyl content, activity of superoxide dismutase (SOD), activities of aldose reductase (AR), and sorbitol levels were assayed, respectively. Supplementation of vanadium to alloxan-induced diabetic rats decreased the blood glucose levels due to hyperglycemia, inhibited the AR activity, and delayed cataract progression in a dose-dependent manner. The observed beneficial effects may be attributed to polyol pathway activation but not decreased oxidative stress. Overall, the results of this study demonstrate that vanadium could effectively reduce the alloxan-induced hyperglycemia and diabetic cataracts in rats. Keywords Vanadium . Diabetes . Blood glucose . Cataract
Introduction Diabetes recently has reached almost epidemic levels worldwide. Diabetic cataract is one of the earliest secondary complications of diabetes, and it is characterized by opacification of the eye lens [1]. Approximately 42 % of the world’s blindness can be attributed to diabetic cataracts [2]. Diabetes-associated cataractogenesis is well known to be initiated by osmotic stress caused by the intralenticular accumulation of polyols produced by the polyol pathway [3, 4]. In L. Sun : D.
