HHS Public Access Author manuscript Author Manuscript
Mayo Clin Proc. Author manuscript; available in PMC 2017 May 01. Published in final edited form as: Mayo Clin Proc. 2016 May ; 91(5): 623–633. doi:10.1016/j.mayocp.2016.02.026.
THE NATURAL HISTORY OF PATIENTS WITH ISOLATED METABOLIC SYNDROME Pratik A. Patel, MD1, Christopher G. Scott, MSc2, Richard J. Rodeheffer, MD3, and Horng H. Chen, MB,BCh3
Author Manuscript
1
Department of Internal Medicine, Mayo Clinic, Rochester, MN
2
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN
3
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
Abstract Objectives—To define the natural history of patients with Isolated metabolic syndrome.
Author Manuscript
Patients & Methods—Metabolic syndrome (MS) is associated with increased risk of cardiovascular mortality. Isolated MS patients are a subset of MS patients who don't meet the diagnostic criteria of hypertension (HTN) and diabetes mellitus(DM).Data was collected prospectively on a population-based random sample of 1042 Olmsted County, Minnesota, residents aged 45 years or older who underwent clinical evaluation, medical record abstraction, and echocardiography (Visit 1 January 1,1997-December 31, 2000). The cohort was subdivided into healthy controls, isolated MS and MS with HTN and/or DM groups. After four years, patients returned for Visit 2 (September 1, 2001-December 30, 2004). After Visit 2, we have a median of 8.3 years of follow-up. Results—There was a higher incidence of hypertension, diabetes and obesity in the isolated MS group at Visit 2 (P1.5, deceleration time
Mayo Clin Proc. Author manuscript; available in PMC 2017 May 01. Published in final edited form as: Mayo Clin Proc. 2016 May ; 91(5): 623–633. doi:10.1016/j.mayocp.2016.02.026.
THE NATURAL HISTORY OF PATIENTS WITH ISOLATED METABOLIC SYNDROME Pratik A. Patel, MD1, Christopher G. Scott, MSc2, Richard J. Rodeheffer, MD3, and Horng H. Chen, MB,BCh3
Author Manuscript
1
Department of Internal Medicine, Mayo Clinic, Rochester, MN
2
Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN
3
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN
Abstract Objectives—To define the natural history of patients with Isolated metabolic syndrome.
Author Manuscript
Patients & Methods—Metabolic syndrome (MS) is associated with increased risk of cardiovascular mortality. Isolated MS patients are a subset of MS patients who don't meet the diagnostic criteria of hypertension (HTN) and diabetes mellitus(DM).Data was collected prospectively on a population-based random sample of 1042 Olmsted County, Minnesota, residents aged 45 years or older who underwent clinical evaluation, medical record abstraction, and echocardiography (Visit 1 January 1,1997-December 31, 2000). The cohort was subdivided into healthy controls, isolated MS and MS with HTN and/or DM groups. After four years, patients returned for Visit 2 (September 1, 2001-December 30, 2004). After Visit 2, we have a median of 8.3 years of follow-up. Results—There was a higher incidence of hypertension, diabetes and obesity in the isolated MS group at Visit 2 (P1.5, deceleration time
