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Vascular OnlineFirst, published on September 22, 2014 as doi:10.1177/1708538114552464
Original Article
The national incidence of iatrogenic popliteal artery injury during total knee replacement
Vascular 0(0) 1–4 ! The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1708538114552464 vas.sagepub.com
Anahita Dua1,2, Reyna Zepeda3, Francisco C Hernanez4, Anthony A Igbadumhe5 and Sapan S Desai6
Abstract Introduction: The aim of this study was to characterize national characteristics of patients who have a total knee replacement complicated by popliteal artery injury by incidence and patient demographics. Methods: All patients with ICD-9 confirmed total knee replacement who had an iatrogenic popliteal artery injury were included from the national in-patient sample from 1998 to 2011. Age, gender and race, procedure type, time to popliteal artery injury, limb outcome, length of stay and hospital inpatient charges were reported. Results: A total of 1,297,369 patients underwent a total knee replacement of which 43 were complicated by popliteal artery injury (0.003%); 93% had osteoarthritis as their primary diagnosis. The mean age was 61.7 12.3 years. In all, 96% of patients had their popliteal injuries detected intra-operatively or on the day of total knee replacement surgery. The majority of these patients either received stent placement (44%) or peripheral bypass (30%) as their treatment modality for popliteal artery injury. There were no amputations or deaths in this cohort. The median hospital charges for this group were $27,570 (2014 USD). Conclusion: The national incidence of iatrogenic popliteal artery injury in patients undergoing TKR is 0.003%. There were no amputations in our study population and 96% of patients had their injury detected intra-operative or immediately post-operatively.
Keywords Total knee replacement, vascular injury and total knee replacement, iatrogenic popliteal artery injury, limb salvage in iatrogenic injury
Introduction There is an increasing incidence in the utilization of total knee replacement (TKR) for nontraumatic, osteoarthritic patients.1 TKR is nearly as prevalent as congestive heart failure in elderly patients with almost 1.5 million patients in the 50- to 69-year category. In the USA, over half of the patients with an osteoarthritis diagnosis will undergo TKR. There are currently 4.0 million patients in the US with a TKR.1,2 One of the most dreaded complications of TKR is injury to the popliteal vessels that are in close proximity to the joint. Popliteal artery injury is associated with the highest rates of amputation of all extremity vasculature injuries as tibial run-off to the distal extremity may be dependent on this single vessel.3,4 Trauma to the popliteal artery and/or vein during a TKR can
result in hemorrhage, infection, graft loss, functional abnormalities and even loss of the limb.1–5 In the elderly patient population injury and manipulation of the popliteal vasculature may result in immobilization 1
Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA 2 Center for Translational Injury Research (CeTIR), Department of Surgery, University of Texas-Houston, Houston, TX, USA 3 National Autonomous University of Nicaragua, Managua, Nicaragua 4 University of Carabobo School of Medicine, Valencia, Venezuela 5 Ambrose Alli University College of Medicine, Ekpoma, Nigeria 6 Department of Vascular Surgery, Southern Illinois University, Springfield, IL, USA Corresponding author: Anahita Dua MD, MS, MBA, Department of Surgery, Medical College of Wisconsin, 8701 West Wisconsin Ave, Milwaukee, WI 3226, USA. Email: [email protected]
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which could lead to higher rates of deep vein thrombosis and/or pulmonary embolism which are already highest for the orthopedic patient population.6 Popliteal artery injury during TKR is a rare occurrence making studying the incidence of this complication challenging. Case series from single institutions or and small multicenter studies place the incidence between 0.03 and 0.17%.2,7–10 This uncommonness of popliteal vasculature injury during TKR makes studies about its overall incidence, trends and outcomes difficult at a local level. The National Inpatient Sample (NIS) is a large, national database inclusive of a 20% stratified sample of all inpatient hospital admissions to non-governmental hospitals in the USA. This database captures demographics, inpatient hospital charges, procedures and outcomes of patients during a single hospital stay and is a validated way to determine national incidence patterns of rare disease processes (NIS).11 The aim of this study was to characterize national characteristics of patients who have a TKR complicated by popliteal artery injury over a decade in the US by incidence, patient demographics, limb outcomes and hospital covariates.
Methods This was a retrospective cross-sectional analysis of hospital discharge data from 1998 to 2011 using the Health Care Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database, which is a stratified 20% sample of all inpatient admissions to nonfederal, acute care hospitals maintained by the Agency for Healthcare Research and Quality (AHRQ).11 It is the largest all-payer inpatient database in the US, with records from approximately eight million hospital stays each year.11 Records were limited to inpatients who underwent TKR (ICD-9 code 8154) as their primary procedure that was complicated by a popliteal artery injury identified using the ICD-9 diagnosis codes 90440 and 90441.
LOS and total charges. Data analysis and management were completed using IBM SPSS (SPSS version 22.0; SPSS Inc, Chicago, IL). Statistical significance was set at a level of p < .05. Population estimates are calculated using weighted samples and data provided by the US Census Bureau. Values are presented as mean standard deviation for age. Median costs are presented in 2014 USD corrected using the Consumer Price Index, and are available in the NIS starting in 2001.
Results From 1998 to 2011, 1,297,369 patients underwent a TKR of which 43 were complicated by popliteal artery injury (0.003%); 93% (40) had osteoarthritis as their primary diagnosis, 5% (2) had a complication of an orthopedic device and 2% (1) had rheumatoid arthritis. The majority of patients who had a popliteal artery complication during their TKR procedure were female (65%) and the overall patient population had a mean age of 61.7 12.3 years. Most patients were Caucasian (87%), followed by African Americans (7%) or Hispanic (3.3%). In all, 96% (41) of patients had their popliteal injuries detected intra-operatively or on the day of TKR surgery, 2% (1) were detected on post-operative day 1 and 2% (1) had their vascular injury detected at 3 days. Table 1 details the vascular procedures these patients cohort underwent to re-establish distal flow. The majority of these patients either received stent placement (44%) or peripheral bypass (30%) as their treatment modality for popliteal artery injury. Thirtyday patency for this group was as follows: 96% (41) had a successful procedure with restored distal blood flow. One patient had a peripheral bypass complication that required a redo-bypass on post-operative day 16 and one other patient had a patch angioplasty and required an embolectomy on post-operative day 1. There were no amputations or deaths in this cohort. The median hospital charges for this group were $27,570 (2014 USD).
Variables Patient-level covariates included age, gender and race/ ethnicity (white, black, Hispanic, other, as coded in HCUP-NIS). Clinical covariates included procedure type, time to popliteal artery injury, limb outcome, length of stay and hospital inpatient charges.
Statistical analysis Statistical analysis was completed with the use of analysis of variance for continuous variables (i.e. age) and Chi square test for categorical variables (i.e. sex, race and mortality). The Mann-Whitney U test was used for
Table 1. Details of the vascular procedures of this patient cohort. Vascular procedure performed
N, percentage (%)
Endovascular stent-graft Peripheral bypass Patch angioplasty Vein repair/ligation Amputation
19 13 7 4 0
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(44) (30) (16) (9) (0)
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(VAS)
[1–4] [PREPRINTER stage]
Dua et al.
3
Discussion
Limitations
While iatrogenic injury to the popliteal vasculature is a rare event, complications from popliteal trauma can be significant.3,4 Popliteal artery injury is associated in the trauma population with an amputation rate of up to 30%, the highest amputation rate in extremity vascular injury.3,4 Popliteal injury can result in hemorrhage, infection of the TKR implant, nerve injury, hematoma, aneurysm or further dreaded complications such as deep vein thrombosis or pulmonary embolism especially if the popliteal vein is impacted.1–7 Most studies detailing the incidence and trends associated with popliteal artery trauma and TKR are case series or small multicenter studies that have placed the incidence between 0.03 and 0.17%.2,7–10 Our national data over a 14-year period in the USA noted an even further reduced incidence of 43 per 1,297,369 patients or 0.003%. As in other studies, our study found the majority of patients nationally had osteoarthritis reported as the reason for TKR, had a mean age greater than 60 years and were female.7–10 Unfortunately, as this was a database study the cause of popliteal artery injury could not be ascertained but previous reports have stated that the utilization of tourniquets, thrombosis via blunt injury or direct penetrating injury with orthopedic instruments are all causes of popliteal injury.2 The detection of injury early is associated with limb salvage as prompt vascular intervention may be instituted.2 We had no amputations in our patient population and that may be related to the fact that 96% of patients had their injury noted either intra-operatively during TKR or during the same day of TKR. It is also important to note that the NIS database is a 20% weighted sample of the entire in-hospital admission patient population and hence this 0% amputation rate underestimates the actual incidence; 100% of patients had their vascular injury detected by 3 days post TKR. In the case of acute intra-operative bleeding, the source should be localized and an expert assistance consulted immediately. There is always a possibility of a vascular injury in the face of an expanding hematoma or obvious signs of ischemia especially during revision arthroplasty.5 If a bleeding source is not obvious external pressure is warranted but application of vascular clamps blindly can cause further injury.5 Older patients undergoing TKR with popliteal injury tend to undergo stenting or bypass as we report in this study because of systemic atherosclerosis and the need to ensure adequate distal perfusion. We did not find that patency rates in this patient population were any less than that of patients who have revascularizations performed in an elective setting but this may be due to a small sample.12
This study uses an administrative database, which is limited with regard to the number of variables that can be measured. Follow-up data and long-term outcomes are unavailable and the highest risk of vascular injury is the need for repeat surgery and loosening of the acetabular component which this study cannot comment on. Importantly, given that this is a database study that utilizes a database constituting 20% of the USA in-hospital admission sample, the 0% amputation rate is an underestimate of the actual incidence. This also limits the ability to calculate costs associated with popliteal artery injury with TKR follow-up.
Conclusion The national incidence of iatrogenic popliteal artery injury over a 14-year period in patients undergoing TKR is 0.003% in the USA. Most patients are Caucasian females with osteoarthritis. There were no amputations in our study population and 96% of patients had their injury detected intra-operative or immediately post-operatively. Conflict of interest None declared.
Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
References 1. Weinstein AM, Rome BN, Reichmann WM, et al. Estimating the burden of total knee replacement in the United States. J Bone Joint Surg Am 2013; 95: 385–392. 2. Bernhoff K, Rudstro¨m H, Gedeborg R, et al. Popliteal artery injury during knee replacement: a populationbased nationwide study. Bone Joint J 2013; 95-B: 1645–1649. 3. Dua A, Desai SS, Shah JO, et al. Outcome predictors of limb salvage in traumatic popliteal artery injury. Ann Vasc Surg 2014; 28: 108–114. 4. Dua A, Patel B, Desai SS, et al. Comparison of military and civilian popliteal artery trauma outcomes. J Vasc Surg 2014; 59: 1628–1632. 5. Novotny´ K, Pa´dr R, Landor I, et al. Vascular injuries in joint replacement surgery. Acta Chir Orthop Traumatol Cech 2011; 78: 200–207. 6. Dua A, Neiva S and Sutherland A. Does previous varicose vein surgery alter deep vein thrombosis risk after lower limb arthroplasty? Orthop Surg 2012; 4: 222–226. 7. Rand JA. Vascular complications of total knee arthroplasty: report of three cases. J Arthroplasty 1987; 2: 89–93.
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8. Abularrage CJ, Weiswasser JM, Dezee KJ, et al. Predictors of lower extremity arterial injury after total knee or total hip arthroplasty. J Vasc Surg 2008; 47: 803–807. 9. Calligaro KD, Dougherty MJ, Ryan S, et al. Acute arterial complications associated with total hip and knee arthroplasty. J Vasc Surg 2003; 38: 1170–1177. 10. Troutman DA, Dougherty MJ, Spivack AI, et al. Updated strategies to treat acute arterial complications
associated with total knee and hip arthroplasty. J Vasc Surg 2013; 58: 1037–1042. 11. Overview of the national in-patient sample, http:// www.hcup-us.ahrq.gov/nisoverview.jsp (accessed: 30 March 2014). 12. Joh JH, Joo SH and Park HC. Simultaneous hybrid revascularization for symptomatic lower extremity arterial occlusive disease. Exp Ther Med 2014; 7: 804–810.
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(VAS)
[1–4] [PREPRINTER stage]
Vascular OnlineFirst, published on September 22, 2014 as doi:10.1177/1708538114552464
Original Article
The national incidence of iatrogenic popliteal artery injury during total knee replacement
Vascular 0(0) 1–4 ! The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/1708538114552464 vas.sagepub.com
Anahita Dua1,2, Reyna Zepeda3, Francisco C Hernanez4, Anthony A Igbadumhe5 and Sapan S Desai6
Abstract Introduction: The aim of this study was to characterize national characteristics of patients who have a total knee replacement complicated by popliteal artery injury by incidence and patient demographics. Methods: All patients with ICD-9 confirmed total knee replacement who had an iatrogenic popliteal artery injury were included from the national in-patient sample from 1998 to 2011. Age, gender and race, procedure type, time to popliteal artery injury, limb outcome, length of stay and hospital inpatient charges were reported. Results: A total of 1,297,369 patients underwent a total knee replacement of which 43 were complicated by popliteal artery injury (0.003%); 93% had osteoarthritis as their primary diagnosis. The mean age was 61.7 12.3 years. In all, 96% of patients had their popliteal injuries detected intra-operatively or on the day of total knee replacement surgery. The majority of these patients either received stent placement (44%) or peripheral bypass (30%) as their treatment modality for popliteal artery injury. There were no amputations or deaths in this cohort. The median hospital charges for this group were $27,570 (2014 USD). Conclusion: The national incidence of iatrogenic popliteal artery injury in patients undergoing TKR is 0.003%. There were no amputations in our study population and 96% of patients had their injury detected intra-operative or immediately post-operatively.
Keywords Total knee replacement, vascular injury and total knee replacement, iatrogenic popliteal artery injury, limb salvage in iatrogenic injury
Introduction There is an increasing incidence in the utilization of total knee replacement (TKR) for nontraumatic, osteoarthritic patients.1 TKR is nearly as prevalent as congestive heart failure in elderly patients with almost 1.5 million patients in the 50- to 69-year category. In the USA, over half of the patients with an osteoarthritis diagnosis will undergo TKR. There are currently 4.0 million patients in the US with a TKR.1,2 One of the most dreaded complications of TKR is injury to the popliteal vessels that are in close proximity to the joint. Popliteal artery injury is associated with the highest rates of amputation of all extremity vasculature injuries as tibial run-off to the distal extremity may be dependent on this single vessel.3,4 Trauma to the popliteal artery and/or vein during a TKR can
result in hemorrhage, infection, graft loss, functional abnormalities and even loss of the limb.1–5 In the elderly patient population injury and manipulation of the popliteal vasculature may result in immobilization 1
Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA 2 Center for Translational Injury Research (CeTIR), Department of Surgery, University of Texas-Houston, Houston, TX, USA 3 National Autonomous University of Nicaragua, Managua, Nicaragua 4 University of Carabobo School of Medicine, Valencia, Venezuela 5 Ambrose Alli University College of Medicine, Ekpoma, Nigeria 6 Department of Vascular Surgery, Southern Illinois University, Springfield, IL, USA Corresponding author: Anahita Dua MD, MS, MBA, Department of Surgery, Medical College of Wisconsin, 8701 West Wisconsin Ave, Milwaukee, WI 3226, USA. Email: [email protected]
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which could lead to higher rates of deep vein thrombosis and/or pulmonary embolism which are already highest for the orthopedic patient population.6 Popliteal artery injury during TKR is a rare occurrence making studying the incidence of this complication challenging. Case series from single institutions or and small multicenter studies place the incidence between 0.03 and 0.17%.2,7–10 This uncommonness of popliteal vasculature injury during TKR makes studies about its overall incidence, trends and outcomes difficult at a local level. The National Inpatient Sample (NIS) is a large, national database inclusive of a 20% stratified sample of all inpatient hospital admissions to non-governmental hospitals in the USA. This database captures demographics, inpatient hospital charges, procedures and outcomes of patients during a single hospital stay and is a validated way to determine national incidence patterns of rare disease processes (NIS).11 The aim of this study was to characterize national characteristics of patients who have a TKR complicated by popliteal artery injury over a decade in the US by incidence, patient demographics, limb outcomes and hospital covariates.
Methods This was a retrospective cross-sectional analysis of hospital discharge data from 1998 to 2011 using the Health Care Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) database, which is a stratified 20% sample of all inpatient admissions to nonfederal, acute care hospitals maintained by the Agency for Healthcare Research and Quality (AHRQ).11 It is the largest all-payer inpatient database in the US, with records from approximately eight million hospital stays each year.11 Records were limited to inpatients who underwent TKR (ICD-9 code 8154) as their primary procedure that was complicated by a popliteal artery injury identified using the ICD-9 diagnosis codes 90440 and 90441.
LOS and total charges. Data analysis and management were completed using IBM SPSS (SPSS version 22.0; SPSS Inc, Chicago, IL). Statistical significance was set at a level of p < .05. Population estimates are calculated using weighted samples and data provided by the US Census Bureau. Values are presented as mean standard deviation for age. Median costs are presented in 2014 USD corrected using the Consumer Price Index, and are available in the NIS starting in 2001.
Results From 1998 to 2011, 1,297,369 patients underwent a TKR of which 43 were complicated by popliteal artery injury (0.003%); 93% (40) had osteoarthritis as their primary diagnosis, 5% (2) had a complication of an orthopedic device and 2% (1) had rheumatoid arthritis. The majority of patients who had a popliteal artery complication during their TKR procedure were female (65%) and the overall patient population had a mean age of 61.7 12.3 years. Most patients were Caucasian (87%), followed by African Americans (7%) or Hispanic (3.3%). In all, 96% (41) of patients had their popliteal injuries detected intra-operatively or on the day of TKR surgery, 2% (1) were detected on post-operative day 1 and 2% (1) had their vascular injury detected at 3 days. Table 1 details the vascular procedures these patients cohort underwent to re-establish distal flow. The majority of these patients either received stent placement (44%) or peripheral bypass (30%) as their treatment modality for popliteal artery injury. Thirtyday patency for this group was as follows: 96% (41) had a successful procedure with restored distal blood flow. One patient had a peripheral bypass complication that required a redo-bypass on post-operative day 16 and one other patient had a patch angioplasty and required an embolectomy on post-operative day 1. There were no amputations or deaths in this cohort. The median hospital charges for this group were $27,570 (2014 USD).
Variables Patient-level covariates included age, gender and race/ ethnicity (white, black, Hispanic, other, as coded in HCUP-NIS). Clinical covariates included procedure type, time to popliteal artery injury, limb outcome, length of stay and hospital inpatient charges.
Statistical analysis Statistical analysis was completed with the use of analysis of variance for continuous variables (i.e. age) and Chi square test for categorical variables (i.e. sex, race and mortality). The Mann-Whitney U test was used for
Table 1. Details of the vascular procedures of this patient cohort. Vascular procedure performed
N, percentage (%)
Endovascular stent-graft Peripheral bypass Patch angioplasty Vein repair/ligation Amputation
19 13 7 4 0
Downloaded from vas.sagepub.com at Stockholm University Library on October 11, 2015
(44) (30) (16) (9) (0)
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(VAS)
[1–4] [PREPRINTER stage]
Dua et al.
3
Discussion
Limitations
While iatrogenic injury to the popliteal vasculature is a rare event, complications from popliteal trauma can be significant.3,4 Popliteal artery injury is associated in the trauma population with an amputation rate of up to 30%, the highest amputation rate in extremity vascular injury.3,4 Popliteal injury can result in hemorrhage, infection of the TKR implant, nerve injury, hematoma, aneurysm or further dreaded complications such as deep vein thrombosis or pulmonary embolism especially if the popliteal vein is impacted.1–7 Most studies detailing the incidence and trends associated with popliteal artery trauma and TKR are case series or small multicenter studies that have placed the incidence between 0.03 and 0.17%.2,7–10 Our national data over a 14-year period in the USA noted an even further reduced incidence of 43 per 1,297,369 patients or 0.003%. As in other studies, our study found the majority of patients nationally had osteoarthritis reported as the reason for TKR, had a mean age greater than 60 years and were female.7–10 Unfortunately, as this was a database study the cause of popliteal artery injury could not be ascertained but previous reports have stated that the utilization of tourniquets, thrombosis via blunt injury or direct penetrating injury with orthopedic instruments are all causes of popliteal injury.2 The detection of injury early is associated with limb salvage as prompt vascular intervention may be instituted.2 We had no amputations in our patient population and that may be related to the fact that 96% of patients had their injury noted either intra-operatively during TKR or during the same day of TKR. It is also important to note that the NIS database is a 20% weighted sample of the entire in-hospital admission patient population and hence this 0% amputation rate underestimates the actual incidence; 100% of patients had their vascular injury detected by 3 days post TKR. In the case of acute intra-operative bleeding, the source should be localized and an expert assistance consulted immediately. There is always a possibility of a vascular injury in the face of an expanding hematoma or obvious signs of ischemia especially during revision arthroplasty.5 If a bleeding source is not obvious external pressure is warranted but application of vascular clamps blindly can cause further injury.5 Older patients undergoing TKR with popliteal injury tend to undergo stenting or bypass as we report in this study because of systemic atherosclerosis and the need to ensure adequate distal perfusion. We did not find that patency rates in this patient population were any less than that of patients who have revascularizations performed in an elective setting but this may be due to a small sample.12
This study uses an administrative database, which is limited with regard to the number of variables that can be measured. Follow-up data and long-term outcomes are unavailable and the highest risk of vascular injury is the need for repeat surgery and loosening of the acetabular component which this study cannot comment on. Importantly, given that this is a database study that utilizes a database constituting 20% of the USA in-hospital admission sample, the 0% amputation rate is an underestimate of the actual incidence. This also limits the ability to calculate costs associated with popliteal artery injury with TKR follow-up.
Conclusion The national incidence of iatrogenic popliteal artery injury over a 14-year period in patients undergoing TKR is 0.003% in the USA. Most patients are Caucasian females with osteoarthritis. There were no amputations in our study population and 96% of patients had their injury detected intra-operative or immediately post-operatively. Conflict of interest None declared.
Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
References 1. Weinstein AM, Rome BN, Reichmann WM, et al. Estimating the burden of total knee replacement in the United States. J Bone Joint Surg Am 2013; 95: 385–392. 2. Bernhoff K, Rudstro¨m H, Gedeborg R, et al. Popliteal artery injury during knee replacement: a populationbased nationwide study. Bone Joint J 2013; 95-B: 1645–1649. 3. Dua A, Desai SS, Shah JO, et al. Outcome predictors of limb salvage in traumatic popliteal artery injury. Ann Vasc Surg 2014; 28: 108–114. 4. Dua A, Patel B, Desai SS, et al. Comparison of military and civilian popliteal artery trauma outcomes. J Vasc Surg 2014; 59: 1628–1632. 5. Novotny´ K, Pa´dr R, Landor I, et al. Vascular injuries in joint replacement surgery. Acta Chir Orthop Traumatol Cech 2011; 78: 200–207. 6. Dua A, Neiva S and Sutherland A. Does previous varicose vein surgery alter deep vein thrombosis risk after lower limb arthroplasty? Orthop Surg 2012; 4: 222–226. 7. Rand JA. Vascular complications of total knee arthroplasty: report of three cases. J Arthroplasty 1987; 2: 89–93.
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8. Abularrage CJ, Weiswasser JM, Dezee KJ, et al. Predictors of lower extremity arterial injury after total knee or total hip arthroplasty. J Vasc Surg 2008; 47: 803–807. 9. Calligaro KD, Dougherty MJ, Ryan S, et al. Acute arterial complications associated with total hip and knee arthroplasty. J Vasc Surg 2003; 38: 1170–1177. 10. Troutman DA, Dougherty MJ, Spivack AI, et al. Updated strategies to treat acute arterial complications
associated with total knee and hip arthroplasty. J Vasc Surg 2013; 58: 1037–1042. 11. Overview of the national in-patient sample, http:// www.hcup-us.ahrq.gov/nisoverview.jsp (accessed: 30 March 2014). 12. Joh JH, Joo SH and Park HC. Simultaneous hybrid revascularization for symptomatic lower extremity arterial occlusive disease. Exp Ther Med 2014; 7: 804–810.
Downloaded from vas.sagepub.com at Stockholm University Library on October 11, 2015
