ACTA ENDOCRINOLOGICA

83

(1976)

365-372

Laboratoire de Physiologie Endocrinienne Infantile, I. N. S. E. R. M. No. U 142,

Hôpital Trousseau,

Paris

75012 -

THE LIVER AS A SOURCE OF SOMATOMEDIN

An in vivo

study

in the

dog

By

R. M.

M. Donnadieu, J. C. Glasinovic, M. Warnet and F. Girard

Schimpff, J.

ABSTRACT Somatomedin (Sm) activity (measured by [35S] uptake in chick embryo cartilage) was determined in serum samples simultaneously drawn from the hepatic vein, portal vein, femoral artery and femoral vein of seventeen anaesthezied normal adult dogs). A pool of human serum was taken as reference (Sm 1 U/ml). Sm levels in the peripheral vein of dogs were 0.38 \m=+-\0.03 U/ml). Mean \m=+-\sem). Sm activity was greater in the hepatic vein (0.48 U/ml) than in the other vessels (0.36, 0.39, 0.38 U/ml), and the paired differences were significant =

(P