J Musculoskelet Neuronal Interact 2015; 15(2):145-153
Original Article
Hylonome
The impact of vitamin D3 supplementation on muscle function among HIV-infected children and young adults: a randomized controlled trial J.C. Brown1, J.I. Schall2, R.M. Rutstein3,4, M.B. Leonard5, B.S. Zemel2, V.A. Stallings2,4 1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine; Division of Gastroenterology, Hepatology, and Nutrition; 3Division of General Pediatrics, Children’s Hospital of Philadelphia, 4Department of Pediatrics, University of Pennsylvania Perelman School of Medicine Philadelphia, PA; 5Division of Nephrology, Department of Pediatrics, Stanford School of Medicine, Stanford, CA
2
Abstract Objectives: We tested the hypothesis that daily vitD3 supplementation increases neuromuscular motor skills, jump power, jump energy, muscular force, and muscular strength. Methods: This was a secondary analysis of a randomized controlled trial of 12-months of oral 7,000 IU/day vitD3 supplementation or placebo among 56 persons living with HIV aged 9-25 years. Neuromuscular motor skills were quantified using the Bruininks-Oseretsky Test of Motor Proficiency. Power was quantified using peak jump power, and energy was quantified using peak jump height. Muscular force was quantified using isometric ankle plantarand dorsiflexion, isokinetic knee flexion and extension. Muscular strength was quantified using isometric handgrip strength. Results: After 12-months, serum 25-hydroxyvitamin D [25(OH)D] was higher with supplementation versus placebo (β=12.1 ng/mL; P
Original Article
Hylonome
The impact of vitamin D3 supplementation on muscle function among HIV-infected children and young adults: a randomized controlled trial J.C. Brown1, J.I. Schall2, R.M. Rutstein3,4, M.B. Leonard5, B.S. Zemel2, V.A. Stallings2,4 1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine; Division of Gastroenterology, Hepatology, and Nutrition; 3Division of General Pediatrics, Children’s Hospital of Philadelphia, 4Department of Pediatrics, University of Pennsylvania Perelman School of Medicine Philadelphia, PA; 5Division of Nephrology, Department of Pediatrics, Stanford School of Medicine, Stanford, CA
2
Abstract Objectives: We tested the hypothesis that daily vitD3 supplementation increases neuromuscular motor skills, jump power, jump energy, muscular force, and muscular strength. Methods: This was a secondary analysis of a randomized controlled trial of 12-months of oral 7,000 IU/day vitD3 supplementation or placebo among 56 persons living with HIV aged 9-25 years. Neuromuscular motor skills were quantified using the Bruininks-Oseretsky Test of Motor Proficiency. Power was quantified using peak jump power, and energy was quantified using peak jump height. Muscular force was quantified using isometric ankle plantarand dorsiflexion, isokinetic knee flexion and extension. Muscular strength was quantified using isometric handgrip strength. Results: After 12-months, serum 25-hydroxyvitamin D [25(OH)D] was higher with supplementation versus placebo (β=12.1 ng/mL; P
