Liver International ISSN 1478-3223
METABOLIC AND STEATOHEPATITIS
The impact of gender and NASH on chronic kidney disease before and after liver transplantation Lynn A. Fussner1, Michael R. Charlton1,4, Julie K. Heimbach2, Chun Fan3, Ross Dierkhising3, Elizabeth Coss1 and Kymberly D. Watt1,4 1 2 3 4
Department of Internal Medicine, Mayo Clinic Transplant Center, Rochester, MN, USA Department of Surgery, Mayo Clinic Transplant Center, Rochester, MN, USA Division of Biomedical Statistics and Informatics, Mayo Clinic Transplant Center, Rochester, MN, USA Division of Gastroenterology and Hepatology, Mayo Clinic Transplant Center, Rochester, MN, USA
Keywords chronic kidney disease – diabetes – female – non-alcoholic steatohepatitis – renal failure Abbreviations BMI, body mass index; CI, confidence interval; GFR, glomerular filtration rate; LT, liver transplant; MELD, model of end-stage liver disease; NASH, non-alcoholic steatohepatitis; OR, odds ratio. Correspondence Kymberly D Watt, MD, Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation CH-10 200 First St. S.W. Rochester, MN 55905, USA Tel: +507 266 1586 Fax:+507 266 1856 e-mail: [email protected] Received 3 July 2013 Accepted 27 October 2013 DOI:10.1111/liv.12381 Liver Int. 2014: 34: 1259–1266
Abstract Background & Aims: Chronic kidney disease (CKD) after liver transplant (LT) is associated with increased long-term mortality. The impact of gender on CKD before and after LT is unknown. To further define risk factors and analyse gender differences in the incidence and progression of CKD after liver transplant. Methods: Four hundred and fifty-five consecutive adult primary solitary LT recipients were included. Iothalamate clearance tests performed over time were analysed. Results: Mean age was 51.4 ± 10.4 years with 63% males. A percentage of 29.1% of females and 21.1% of males had a GFR
METABOLIC AND STEATOHEPATITIS
The impact of gender and NASH on chronic kidney disease before and after liver transplantation Lynn A. Fussner1, Michael R. Charlton1,4, Julie K. Heimbach2, Chun Fan3, Ross Dierkhising3, Elizabeth Coss1 and Kymberly D. Watt1,4 1 2 3 4
Department of Internal Medicine, Mayo Clinic Transplant Center, Rochester, MN, USA Department of Surgery, Mayo Clinic Transplant Center, Rochester, MN, USA Division of Biomedical Statistics and Informatics, Mayo Clinic Transplant Center, Rochester, MN, USA Division of Gastroenterology and Hepatology, Mayo Clinic Transplant Center, Rochester, MN, USA
Keywords chronic kidney disease – diabetes – female – non-alcoholic steatohepatitis – renal failure Abbreviations BMI, body mass index; CI, confidence interval; GFR, glomerular filtration rate; LT, liver transplant; MELD, model of end-stage liver disease; NASH, non-alcoholic steatohepatitis; OR, odds ratio. Correspondence Kymberly D Watt, MD, Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation CH-10 200 First St. S.W. Rochester, MN 55905, USA Tel: +507 266 1586 Fax:+507 266 1856 e-mail: [email protected] Received 3 July 2013 Accepted 27 October 2013 DOI:10.1111/liv.12381 Liver Int. 2014: 34: 1259–1266
Abstract Background & Aims: Chronic kidney disease (CKD) after liver transplant (LT) is associated with increased long-term mortality. The impact of gender on CKD before and after LT is unknown. To further define risk factors and analyse gender differences in the incidence and progression of CKD after liver transplant. Methods: Four hundred and fifty-five consecutive adult primary solitary LT recipients were included. Iothalamate clearance tests performed over time were analysed. Results: Mean age was 51.4 ± 10.4 years with 63% males. A percentage of 29.1% of females and 21.1% of males had a GFR
